Clinical trials: XEROSTOMIA
Healthy Participants Study, Rheumatoid Arthritis
A Phase 1, First-in-Human Study of CND319 in Healthy Participants and Patients With Rheumatic Diseases
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary clinical activity of CND319 in healthy adult participants and patients with rheumatic diseases.
- Conditions
- Healthy Participants Study, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- NCT07712939
- Testing
- CND319
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Candid Therapeutics
Sjogren's Syndrome
Descriptive Study of Variations in Serum Translocation Markers of the Intestinal Microbiota in Patients With Gougerot-Sjögren Syndrome According to Disease Activity
Gougerot-Sjögren syndrome or Sjögren syndrome is a chronic autoimmune disease belonging to connectivitis, the classic triad of symptoms being the association of a sicca syndrome (generally predominant in the mouth and / or…
- Trial name
- IMISS (NCT04462601)
- Testing
- Biomarker detection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sjogren's Syndrome
Implantology and Sjögren's Syndrome
Until now it has not been investigated whether placement of implants in SS patients is less successful than compared to non-SS patients.
- Trial name
- NCT02661243
- Testing
- Biohorizons Laser-lok bonelevel dental implants
- Where
- 5 sites in Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Derk Jan Jager
Sjögren's Syndrome
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
The purpose of the study is to evaluate the efficacy, safety, and tolerability of VIB4920 (formerly MEDI4920) in adult participants with Sjögren's Syndrome (SS).
- Trial name
- SS (NCT04129164)
- Testing
- VIB4920
- Where
- 62 sites in United States, Argentina and 10 more
- Volunteers
- 183 people
- Sponsor
- Amgen
Autoimmune Diseases, Systemic Lupus Erythematosus
Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases
This is an open, single-arm, clinical study to evaluate the efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) targeting BCMA or CD19 or both sequentially in the treatment of Relapsed/ Refractory…
- Conditions
- Autoimmune Diseases, Systemic Lupus Erythematosus, Systemic Lupus Erythematosus Acute, Sjogren's Syndrome
- Trial name
- BAH247 (NCT06428188)
- Testing
- BCMA/CD19 CAR-T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Essen Biotech
Sjogren's Syndrome
Effect of Debridement-scaling on the Relief of Dry Eye Signs and Symptoms in Sjogren's Syndrome
Sjogren's Syndrome is an autoimmune condition in which the body attacks its own glands in the body. Some of these glands are responsible for providing lubrication for the eye.
- Trial name
- TOYOTA (NCT02203188)
- Testing
- Lid debridgement scaling
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Waterloo
Primary Sjogren's Syndrome
Mycophenolate Sodium Treatment in Patients With Primary Sjogren's Syndrome
Primary Sjogren's syndrome (pSS) is an autoimmune disorder characterized by keratoconjunctivitis sicca and xerostomia. In addition, various extraglandular manifestations may develop.
- Trial name
- NCT00542763
- Testing
- Mycophenolate sodium
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Muenster
Rheumatoid Arthritis, Osteoarthritis
Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
B cells are known to play an important role in auto-immune diseases by activating T cells, secreting inflammatory cytokines and autoreactive antibodies.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT01642706
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sjogren Syndrome, Dry Eye Syndrome
Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops
Aqueous deficiency dry eye is mainly caused by Sjogren syndrome (SS), an autoimmune, chronic, inflammatory and systemic disease which affects most commonly the lacrimal and salivary glands.The ocular treatment is focused in…
- Trial name
- NCT01850979
- Testing
- Tacrolimus, Olive Oil
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Nasopharyngeal Carcinoma ,Xerostomia,Radiotherapy
Xerostomia-optimised IMRT Versus Standard IMRT in NPC
This is a multi-center, non-inferiority, open-label, randomized controlled phase III clinical trial in primary diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis.
- Trial name
- NCT06282497
- Testing
- Optimised neck CTV, standard neck CTV
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Rheumatic Diseases, Adult Onset Still Disease
Rheumatology Patient Registry and Biorepository
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
- Conditions
- Rheumatic Diseases, Adult Onset Still Disease, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT04402086
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Xerostomia
Treatment of Xerostomia by Herbal Preparation
The aims of this study are to investigate the effect of famous herbal formula extract on xerostomia, and to determine whether this formula affect various xerostomia-related questionnaires, salivary flow rate, residual saliva and…
- Trial name
- NCT01579877
- Testing
- Herbal extract granule
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Korea Health Industry Development Institute
Chemotherapeutic Agent Toxicity, Mucositis
Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy
This randomized phase II trial is studying how well selenomethionine (SLM) works in reducing mucositis in patients with locally advanced head and neck cancer who are receiving cisplatin and radiation therapy.
- Conditions
- Chemotherapeutic Agent Toxicity, Mucositis, Radiation Toxicity, Stage III Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT01682031
- Testing
- selenomethionine, cisplatin, radiation therapy
- Where
- 2 sites in United States, New Zealand
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Xerostomia, Hyposalivation
Evaluation of an Oral Care Kit for Maintaining the Oral Health of Patients Admitted to the Intensive Care Unit
The goal of this randomized clinical trial is to evaluate the efficacy of the Oral Care Kit, developed by Wecare, in reducing oral mucosal dryness and preventing oral ulcers in patients admitted to the ICU or step-down unit.
- Trial name
- NCT07555444
- Testing
- Oral Care Kit, Artificial Saliva
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Israelita Albert Einstein
Salivary Gland Dysfunction, Xerostomia
Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy
This early phase 1 trial studies the use of everolimus in restoring salivary gland function in participants with locally advanced head and neck cancer after concurrent chemoradiation or radiation therapy alone.
- Conditions
- Salivary Gland Dysfunction, Xerostomia, Head and Neck Cancer
- Trial name
- NCT03578432
- Testing
- Everolimus, Laboratory Biomarker Analysis, Survey Administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arizona
Xerostomia, Diabetes Mellitus
Photobiomodulation In Treatment Of Xerostomia In Type Ii Diabetic Patients
Xerostomia is a major oral health problem that if not recognized and treated can have a significant effect on a patient's quality of life. It leads to difficulties with speech, swallowing and taste alteration.
- Trial name
- NCT06703372
- Testing
- Diode Laser 980 nm, 0.2W
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Hams Hamed Abdelrahman
Sjogren's Syndrome
Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome
Sjogren's syndrome is an autoimmune chronic disease. It has two forms Primary Sjogren's syndrome charactrized by dry eyes and dry mouth.
- Trial name
- NCT03840538
- Testing
- Probiotic Product - Cap
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Sjorgren's Syndrome
Intraglandular Treatment With Adipose-derived Mesenchymal Stem Cells in Patients With Xerostomia Due to Sjögren's Disease
Living with dry mouth significantly impacts daily life, causing constant discomfort. It makes it harder to talk, eat solid food (increasing the risk of malnutrition), swallow, and sleep well.
- Trial name
- ASSIX (NCT06805448)
- Testing
- MSC, Saline Water (Control)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head and Neck Cancer, Head and Neck Neoplasms
Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy
Patients with head and neck cancer post-radiotherapy may improve their perceived and amount of saliva after a 3-month Photobiomodulation (PBM) therapy focuses on three main salivary glands (parotid, submandibular and sublingual…
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Xerostomia
- Trial name
- NCT05614843
- Testing
- Energy density photobiomodulation (7.5)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad de Granada
Sjogren's Disease
Tolerance and Efficacy of Rituximab in Sjogren's Disease
CLINICAL PHASE II INDICATION Sjogren's syndrome RATIONALE Sjögren's syndrome (SS) is an autoimmune disorder affecting 0.2% to 3% of the general population.
- Trial name
- TEARS (NCT00740948)
- Testing
- Rituximab (mabthera) Injection
- Where
- 14 sites in France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Brest