Clinical trials: XEROSTOMIA
Oral Mucositis, Xerostomia
Can Cytokines Predict the Severity of Acute Mucositis and the Need for Gastrostomy Tubes (PEG)?
Mucositis and xerostomia are the most common complications of head and neck (H\&N) irradiation, and the combination of chemotherapy and radiation therapy is associated with a significantly higher rate of complications.
- Conditions
- Oral Mucositis, Xerostomia, Weight Loss, Head and Neck Cancer
- Trial name
- NCT00431925
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Hadassah Medical Organization
Radiation-induced Xerostomia
Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy
The purpose of this study is to determine whether hyperbaric oxygen is effective in the treatment of a dry mouth that occured after radiotherapy for head and neck tumours.
- Trial name
- NCT00682747
- Testing
- Hyperbaric oxygen
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Thomas Kuhnt
Primary Sjögren's Syndrome (pSS)
New Clinical End-points in Patients With Primary Sjögren's Syndrome
There are no approved treatments for pSS and the clinical endpoints currently used in clinical trials are inadequate to capture all aspects of the disease that should be evaluated in clinical trials.
- Trial name
- NECESSITY (NCT05113004)
- Testing
- Hydroxychloroquine 400mg/d, Leflunomide 20mg/d, Mycophenolate mofetil 2000mg/d
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Postoperative Complications
TENS to Alleviate the Effect of Thirty After Surgery Xerostomia (Dry Mouth) After Surgery
Dry mouth of postoperative makes the patient feel thirst, and the pain of the lips is cracked. It will also make the sputum thick and sticky, making it difficult for the patient to cough by himself.
- Trial name
- NCT04898998
- Testing
- Transcutaneous electrical nerve stimulation (TENS), routine care
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- Chang Gung Memorial Hospital
Sjogren Syndrome
Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR).
- Trial name
- SPEEDCARS (NCT02132585)
- Testing
- Speckle tracking echocardiography
- Where
- 2 sites in Italy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Xerostomia, End of Life
A Mouth Education Program for Dry Mouth
The goal of this cluster based intervention trial is to evaluate the effect of a nurse-led patient education program on dry mouth in patients with a life-limiting condition or frailty.
- Conditions
- Xerostomia, End of Life, Frailty, Dry Mouth
- Trial name
- MEP (NCT05964959)
- Testing
- Mouth Educational Program, Care as Usual
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Leiden University Medical Center
Autoimmune Diseases, Autoinflammatory Diseases
Observational Study of Pediatric Rheumatic and Immunologic Diseases in China: The CAPRID Registry
An observational, multi-center, longitudinal registry study for Chinese pediatric patients with rheumatic and immunologic diseases.
- Trial name
- NCT06417502
- Where
- 9 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking Union Medical College Hospital
Head and Neck Carcinoma, Xerostomia
Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck Cancer
This randomized pilot clinical trial studies alternate schedules for acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in treating dry mouth (xerostomia) caused by radiation therapy (RT) in patients with head…
- Trial name
- NCT02474095
- Testing
- Quality-of-Life Assessment, Transcutaneous Acupoint Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute
Sjogren's Disease
Evaluation of Ocular Surface Inflammatory Mediators Effected by Lotemax
The purpose of this study is to evaluate the effects of an anti-inflammatory drug (Lotemax®) on the surface of the eye and tear film (a film that coats the eye which is made up of oil and water).
- Trial name
- NCT02322528
- Testing
- Administration of Lotemax
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Xerostomia, Head and Neck Cancer
Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia
Xerostomia, or dry mouth, is a common side effect of head neck radiation. Current treatment options for radiation-induced xerostomia are generally supportive in nature.
- Trial name
- NCT04007081
- Testing
- Bone Marrow Aspiration, Ultrasound Imaging of Salivary Glands, Salivary Assay
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Xerostomia
Effects of an External Oral Irrigation Device on Patients With Dry Mouth
The purpose of this research study is to test the effectiveness of treating dry mouth through water rehydration using this extra oral water pump/irrigation device.
- Trial name
- NCT04901507
- Testing
- The Voutia System
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Xerostomia
Hypnosis for Treating Xerostomia Following Radiotherapy in Head & Neck Cancer Patients
xerostomia develops in all patients with head and neck cancer following radiotherapy. it consists one of the main side effects which affects quality of life. currently, there is no standard of care for treating this condition.
- Trial name
- NCT00408759
- Testing
- hypnosis
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Bnai Zion Medical Center
Primary Sjögren Syndrome
A Study Evaluating the Effects of GLPG3970 Given as an Oral Treatment for 12 Weeks in Adults With Active Primary Sjögren's Syndrome (pSS)
This is a first exploration of GLPG3970 in participants with active primary Sjogren's Syndrome (pSS) to evaluate the efficacy, safety and tolerability and to determine its pharmacokinetics (PK) profile compared to placebo.
- Trial name
- GLIDER (NCT04700280)
- Testing
- GLPG3970
- Where
- 10 sites in Germany, Greece and 3 more
- Volunteers
- 31 people
- Sponsor
- Lakefront Biotherapeutics NV
Autoimmune Diseases, Pregnancy Related
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and…
- Conditions
- Autoimmune Diseases, Pregnancy Related, Systemic Lupus Erythematosus, Cutaneous Lupus
- Trial name
- MADRA (NCT03276923)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
XEROSTOMIA
Clinical Study New Gel for Xerostomia
At present, there is no single consensus protocol for the treatment of oral dryness, although the main objective is to improve the quality of life of patients.
- Trial name
- XEROSTOMIA (NCT04184908)
- Testing
- gel xerostomia
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Nursing Care
Effect of Diluted Thyme Honey On Dry Mouth In Intensive Care Unit Patients Exposed to Oxygen Flow Therapy
This research is a randomized, controlled, double-blind, experimental study conducted to investigate the effect of diluted thyme honey on dry mouth in individuals receiving treatment in intensive care and receiving nasal oxygen…
- Trial name
- NCT07358494
- Testing
- diluted thyme honey arm, Mouth wash
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Esra Yaprak Gokturk
Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
- Conditions
- Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum, Sjogren Syndrome, Mucous Membrane Pemphigoid
- Trial name
- NCT03839069
- Testing
- minor salivary gland transplantation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Xerostomia
The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia
The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and quality of life of patients…
- Trial name
- NCT06201923
- Testing
- Honey Mouthwash, Normal saline
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Head and Neck Cancer, Oropharyngeal Cancer
Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy
The goal of this clinical research study is to learn if radiation-induced xerostomia [RIX] (dry mouth) causes, or worsens the effects of, acid reflux (heartburn and heartburn-like symptoms) in head and neck cancer (HNC) patients…
- Conditions
- Head and Neck Cancer, Oropharyngeal Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT00928161
- Testing
- Dexlansoprazole
- Sponsor
- M.D. Anderson Cancer Center