Clinical trials: XEROSTOMIA
Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs)
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically…
- Conditions
- Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA
- Trial name
- NCT06991114
- Testing
- Allogeneic NK Cells
- Where
- 52 sites in United States, Brazil and 9 more
- Volunteers
- 90 people
- Sponsor
- Artiva Biotherapeutics, Inc.
Interstitial Lung Disease, Connective Tissue Disease
A Clinical Trial for CTD-ILD Treatment
The first objective of this protocol is to assess the tolerability and safety of N-acetylcysteine (NAC) in patients with connective tissue disease related interstitial lung disease (CTD-ILD).
- Trial name
- NCT01424033
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
Background: Radiation can cause the parotid salivary glands to make less saliva (dry mouth). This can cause problems like infections and tooth decay. Researchers hope a new drug can help people with dry mouth caused by radiation.
- Conditions
- Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
- Trial name
- NCT02446249
- Testing
- AAV2hAQP1
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MeiraGTx, LLC
Inflammatory Disorder of Immune System, Spondylitis, Ankylosing
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant.
- Conditions
- Inflammatory Disorder of Immune System, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- pCB-IMIDs (NCT06842316)
- Testing
- 1 blood sample, 40 mL (collection during a blood test, part of the standard of care for this disease)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Ventilator Associated Pneumonia, Oral Hygiene
Effects of Oral Care in the Neuroscience ICU
The purpose of this study is to compare how effective different ways of mouth cleaning are for patients in a neuroscience intensive care unit with a breathing tube in their mouth.
- Trial name
- NCT00518752
- Testing
- Standard Oral Care, Comprehensive Oral Care
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Head and Neck Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00352118
- Testing
- filgrastim, pegfilgrastim, cisplatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Primary Immune Thrombocytopenia, Sjögren's Syndrome
Managed Access Programs for VAY736, Ianalumab
The purpose of this registration is to list Managed Access Programs (MAPs) related to VAY736, ianalumab
- Trial name
- NCT07244289
- Testing
- ianalumab
- Sponsor
- Novartis Pharmaceuticals
Sjögren's Syndrome (SS)
A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State
Primary Objective: To evaluate the effect of dazodalibep on patient-reported symptoms of SS in participants with moderate-to-severe symptom state Secondary Objectives: 1.
- Trial name
- NCT06245408
- Testing
- Dazodalibep
- Where
- 194 sites in United States, Argentina and 24 more
- Volunteers
- 434 people
- Sponsor
- Amgen
Dry Eye, Dry Eye Syndromes
CEQUA for Sjogren's Syndrome Dry Eye
The primary objective of this study is to show that CEQUA (cyclosporine 0.09% ophthalmic solution) improves symptoms of dry eye disease in a population of patients with Sjogren's Syndrome diagnosis.
- Conditions
- Dry Eye, Dry Eye Syndromes, Sjogren's Syndrome
- Trial name
- NCT04835623
- Testing
- Cyclosporine 0.09% Ophthalmic Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Center for Ophthalmic and Vision Research, LLC
Dry Mouth, Xerostomia.Hyaluronic Acid, Xylitol
CLINICAL EVALUATION OF THE EFFICACY OF AN INTRA ORAL SPRAY FOR PATIENTS WITH XEROSTOMIA
This cross-over group, double-blind, randomized, single center, study will enroll 26 subjects to target at least 24 subjects completing the study.Following an initial 3-5 minute evaluation of resting salivary flow, subjects will…
- Trial name
- NCT04719091
- Testing
- Lubricity
- Volunteers
- 26 people
- Sponsor
- You First Services
Xerostomia, Head and Neck Neoplasms
A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer
This trial is looking at using an intra-oral electrostimulating device for the management of radiotherapy-induced dry mouth.
- Trial name
- LEONIDAS-2 (NCT02941276)
- Testing
- Active Electrostimulator device
- Volunteers
- 84 people
- Sponsor
- University College, London
Sjogren's Disease
ONO-4915 in Patients With Primary Sjogren's Disease
To evaluate the efficacy and safety of ONO-4915 in patients with primary Sjogren's disease
- Trial name
- NCT07823790
- Testing
- ONO-4915
- Volunteers
- 60 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Head and Neck Cancer, Head and Neck Neoplasms
Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study
The Photobiomodulation therapy could have positive effects on quality of life and oral health in head and neck cancer survivors post-radiotherapy. The improvement in quality of life will be maintained after a follow-up period.
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Xerostomia
- Trial name
- LAXER (NCT05106608)
- Testing
- Energy density photobiomodulation (7.5), Energy density photobiomodulation (3)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Dry Eye, Keratoconjunctivitis Sicca
Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye
The purpose of this study is to compare the effects of autologous serum 20% and autologous serum 50% for the treatment of Severe Dry Eye Syndrome
- Conditions
- Dry Eye, Keratoconjunctivitis Sicca, Sjogren's Syndrome, Corneal Diseases
- Trial name
- NCT03436576
- Testing
- Autologous Serum 20%, Autologous Serum 50%
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Xerostomia, Xerostomia Due to Radiotherapy
Finger-prick Autologous Blood (FAB) for Use in Dry Mouth
This is a feasibility study that will assess the efficacy of using autologous blood to treat moderate to severe dry mouth. Dry mouth has been estimated to affect up to 64.8% of the general population (Navazesh et al., 2009) and…
- Conditions
- Xerostomia, Xerostomia Due to Radiotherapy, Xerostomia Due to Hyposecretion of Salivary Gland
- Trial name
- NCT03530735
- Testing
- Finger-prick Autologous Blood (FAB)
- Volunteers
- 20 people
- Sponsor
- Bedford Hospital NHS Trust
Sjogren's Syndrome, Digestive System Abnormalities
Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome
the investigators propose to carry out a prospective study consisting of a systematic research of digestive symptoms in patients with SGSp with the validated Global symptom score (GSS) questionnaire, which allowed to grades…
- Trial name
- GASTRO-SGS (NCT03157011)
- Testing
- Global symptom score (GSS) questionary
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Limoges
Head and Neck Cancer, Oral Complications
Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer
RATIONALE: Cevimeline may be effective in treating dry mouth that is caused by radiation therapy for head and neck cancer. It is not yet known if cevimeline is more effective than no therapy in treating dry mouth caused by…
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00017511
- Testing
- cevimeline hydrochloride
- Where
- 71 sites in United States
- Sponsor
- Daiichi Sankyo
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Inflammatory Myopathies, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06821659
- Testing
- anti-CD19 CAR-T cells
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Head and Neck Cancer
Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.
The purpose of the study is to evaluate the effectiveness of low level laser on radiotherapy induced xerostomia to improve oral function and decrease oral complication due to hyposalivation and thus enhancing survival.
- Trial name
- NCT04700475
- Testing
- low level laser, citric acid solution
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nada Yousef
Sjogren's Syndrome, Interstitial Lung Disease
Sjogren's Lung Study
Lung involvement in Sjögren's syndrome is common and causes reduced quality of life and increased mortality. Sjögren's syndrome-related lung diseases (SS-RLD) are classified and treated as the primary lung diseases they resemble.
- Conditions
- Sjogren's Syndrome, Interstitial Lung Disease, Primary Pulmonary Lymphoma (Disorder), Chronic Bronchiolitis
- Trial name
- NCT04843345
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stanford University