Clinical trials: XEROSTOMIA
Sjogren Syndrome
Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease
Sjögren disease (SjD) is a chronic autoimmune disease in which salivary gland dysfunction commonly causes persistent dry mouth (xerostomia).
- Trial name
- NCT07864987
- Testing
- Oral exercise
- Volunteers
- 56 people
- Sponsor
- Nazli Elif Nacar
Rheumatoid Arthritis, Sjogren's Syndrome
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoid arthritis (RA), Sjogren's…
- Conditions
- Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease
- Trial name
- NCT07180537
- Testing
- Creating Health Online Course, Delayed access to Creating Health Online Course
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
Sjogren's Syndrome, Tomography Optical Coherence
Histopathological Analysis Versus Full-field Optical Coherence Tomography of Minor Salivary Gland Biopsy in Suspect Sjogren Syndrome
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that mainly affects the exocrine glands leading to severe dryness of mucosal surfaces, principally in the mouth and eyes.
- Trial name
- TOCOSS (NCT06454370)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier de Mâcon
Sjogren Syndrome, Mixed Connective Tissue Disease
A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD)
This study was a basket trial designed to establish safety, tolerability and efficacy of MHV370 in Sjögren's Syndrome (SjS) and Mixed Connective Tissue Disease (MCTD).
- Trial name
- NCT04988087
- Testing
- MHV370
- Where
- 10 sites in China, Germany and 4 more
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndrome, Xerophthalmia
To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome
This study wants to use a randomized, single-blind, controlled trial to evaluate the efficacy of receiving acupuncture GB20 or GB20 plus BL2 on alleviating the ocular dryness symptom from dry eye syndrome and Sjögren's syndrome.
- Trial name
- NCT04877483
- Testing
- Acupuncture, Oral microbiota, Schirmer's test
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dry Mouth
Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control
The objective of this study is to evaluate dry mouth relief in subjects with self-reported feeling of dry mouth after using an experimental mouth rinse or a positive control compared to a water control.
- Trial name
- NCT04189081
- Testing
- dry mouth rinse, Water Control
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Rheumatoid Arthritis, Lupus Erythematosus, Systemic
Meir Medical Center Rheumatologic Biobank
Serum, synovial fluid and skin biopsies from patients will be collected to the biobank with rheumatoid diseases. These samples will later be used for clinical and basic research, following approval of each specific study by the…
- Conditions
- Rheumatoid Arthritis, Lupus Erythematosus, Systemic, Systemic Sclerosis, IgG4-related Disease
- Trial name
- NCT03473912
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Meir Medical Center
Diabetes (DM), Dry Mouth
Effects of Chewing Gum for Dry Mouth in Diabetes
Dry mouth can seriously affect the quality of life of individuals because it affects chewing and swallowing functions. One of the diseases in which dry mouth occurs as a side effect of many diseases and/or treatments is diabetes…
- Trial name
- NCT07084532
- Testing
- Chewing gum, Standart therapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Çankırı Karatekin University
Radiation-Induced Xerostomia
Comparative Analysis of BioXtra on Xerostomia
The present study compared the efficacy of BioXtra spray and mouth rinse in the relief of radiotherapy-induced xerostomia in patients referred to Cancer Institute, Tehran Imam Khomeini Hospital.
- Trial name
- BioXtra (NCT01195233)
- Testing
- bioxtra
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Qazvin University Of Medical Sciences
Sjogren's Syndrome
tDCS for Fatigue in Sjogren's Syndrome
Sjogren's Syndrome (SS) is an autoimune disease of unknown etiology characterized by lymphocytic infiltration of the exocrine glands and other organs.
- Trial name
- NCT04119128
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Federal University of São Paulo
Drug-induced Xerostomia
Exploratory Study in the Relief of Drug-induced Xerostomia Associated With Hyposialia
The purpose of this study is to evaluate the clinical efficacy, the safety and acceptability of three new oral sprays with a reference oral spray in the relief of drug-induced xerostomia associated with hyposialia, i.e.
- Trial name
- NCT02005328
- Testing
- Tested product : DC161-DP0291, Tested product : DC161-DP0292, Tested product : DC161-DP0293
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Pierre Fabre Medicament
Congenital Heart Block, Neonatal Lupus
Preventive IVIG Therapy for Congenital Heart Block
Neonatal lupus (NL) is the name given to a group of conditions that can affect the babies of mothers who have certain autoantibodies against components of the body's cells that are called SSA/Ro and SSB/La.
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-associated Heart Block
- Trial name
- PITCH (NCT00460928)
- Testing
- intravenous immune globulin (IVIG)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Xerostomia
NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy
To assess whether the daily use of NeutraSal will prevent or reduce dry mouth in patients undergoing CPAP therapy for OSAS and improve CPAP compliance
- Trial name
- NCT02107300
- Testing
- NeutraSal
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medical University of South Carolina
Sjogren's Syndrome, Keratoconjunctivitis Sicca
Levocarnitine for Dry Eye in Sjogren's Syndrome
This study evaluates the effectiveness of levocarnitine in the treatment of dry eye in adults with Sjogren's syndrome. This will be a crossover study design with all participants receiving both levocarnitine and placebo.
- Trial name
- NCT03953703
- Testing
- Levocarnitine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Overactive Bladder
Observational Study to Estimate the Dry Mouth in OAB Patients With Solifenacin
A prospective, multicenter, observation study to estimate the dry mouth in OAB patients with solifenacin
- Trial name
- OAB (NCT01437670)
- Testing
- solifenacin 5mg, 10mg
- Where
- South Korea
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Head and Neck Cancer, Radiation Toxicity
Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer
RATIONALE: Electroacupuncture may help relieve chronic dry mouth caused by radiation therapy. It is not yet known whether electroacupuncture is more effective than a placebo in treating chronic dry mouth caused by radiation…
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Trial name
- NCT00623129
- Testing
- questionnaire administration, electroacupuncture therapy, management of therapy complications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Sjogren's Syndrome
Sjogren's Mini-Pill Oral and Gut Microbiome Study
The goal of this observational study is to characterize and compare region-specific gastrointestinal, stool, oral, and periodontal microbiomes in adults with Sjögren's disease and healthy controls using ingestible mini-pill…
- Trial name
- NCT07732582
- Testing
- Mini-Pill
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tufts University
Sjogren's Syndrome, Cough
Pulmozyme for Sjogren's Associated Cough
Patients with Sjogren's disease have destruction of the mucus secreting cells in the airway. This manifestation of the disease leads to the common complaint of persistent dry cough that is seen in many of these patients.
- Trial name
- NCT01357447
- Testing
- Dornase alfa, Saline
- Where
- United States
- Sponsor
- UConn Health
Sjogren's Syndrome
A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)
The purpose of this study is to evaluate the efficacy and safety of nipocalimab in participants with primary Sjogren's syndrome (pSS) versus placebo.
- Trial name
- NCT04968912
- Testing
- Nipocalimab, Standard of Care Treatment
- Where
- 69 sites in United States, France and 8 more
- Volunteers
- 163 people
- Sponsor
- Janssen Research & Development, LLC