Clinical trials: XEROSTOMIA
Sjogren's Syndrome, Dry Eye
Nasal Spray Study in Sjogren's Dry Eye Disease
This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and symptoms of dry eye disease in those Sjogren's Syndrome.
- Trial name
- NCT05700422
- Testing
- Varenicline Nasal Spray
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pennsylvania
Sjogren's Syndrome
Interstitial Lung Diseases in Primary Sjogren's Syndrome
Patients with pSS seen in the Division of Rheumatology, the second affiliated hospital of Zhejiang University, School of Medicine (SAHZU) during January 2016 to July 2018, were retrospectively reviewed.
- Trial name
- NCT04978883
- Testing
- No intervention
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Radiation-Induced Xerostomia, Head and Neck Cancer
Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer
This study is being done to find out what effects, good and/or bad, acupuncture has on participants and their xerostomia caused by radiation therapy for the treatment of the cancer.
- Conditions
- Radiation-Induced Xerostomia, Head and Neck Cancer, Radiation Toxicity, Oral Complications of Chemotherapy and Head/Neck Radiation
- Trial name
- ACUPUNCTURE (NCT02589938)
- Testing
- Standard Oral Hygiene, Standard Oral Hygiene + True Acupuncture
- Where
- 36 sites in United States
- Volunteers
- 258 people
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Cancer
Intravenous Versus Subcutaneous Amifostine in Prevention of Xerostomia After RT for Head and Neck Carcinomas
Prospective randomized study in order to compare intravenous versus subcutaneous administration of amifostine in patients receiving radiotherapy for head and neck cancer.
- Trial name
- NCT00158691
- Testing
- Ethyol
- Where
- France
- Volunteers
- 296 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Primer Sjogren's Syndrome
Investigation of the Effectiveness of Cognitive Exercise Therapy Approach in Patients With Primary Sjögren's Syndrome
To determine the effectiveness of the Cognitive Exercise Therapy Approach (BETY in Turkish) in individuals with Primary Sjögren's Syndrome and to compare the effects of this training when applied in groups and individually.
- Trial name
- NCT06398210
- Testing
- Cognitive Exercise Therapy Approach (BETY)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Sjogren's Syndrome, Dysautonomia
Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome
Background: Sj(SqrRoot)(Delta)gren s Syndrome (SS) is an autoimmune disease that affects the glands that produce saliva and tears, causing dry eyes and dry mouth.
- Trial name
- NCT00565526
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
XEROSTOMIA
OGT Spray in the Management of Xerostomia in the Elderly
The primary objective of the trial is to evaluate the efficacy, safety and clinical acceptability of OGT oromucosal spray in the relief of symptoms and signs of xerostomia in comparison with a saliva substitute (European Medical…
- Trial name
- NCT00350350
- Testing
- oxygenated oil, medical device. Spray containing essentially oxygenated oil
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Laboratoires CARILENE
Sjogren's Syndrome, Dry Eye
Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease
This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye.
- Trial name
- JADE (NCT00809003)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Sjogren's Syndrome, Xerostomia
Diagnostic Interest of the Buccal Schirmer Test in Xerostomia During Sjögren's Syndrome: XERODIAG
Xerostomia is a common and very bothersome manifestation that impairs the quality of life in Sjogren's syndrome. Its diagnosis mainly relies on the measurement of salivary flow (SF).
- Conditions
- Sjogren's Syndrome, Xerostomia, Diagnosis
- Trial name
- XERODIAG (NCT06530940)
- Testing
- Buccal Schirmer Test
- Volunteers
- 180 people
- Sponsor
- University Tunis El Manar
Sjögren's Syndrome, Small Fiber Neuropathy
Evaluation of the Prevalence, and Immunological Characteristics of Small Fiber Neuropathy in Patients With Primary Sjögren's Syndrome
The investigators propose to conduct a prospective study evaluating the prevalence of SNN in pSS patients and to find clinical characteristics and specific immunological profiles in pSS patients with SFN.
- Conditions
- Sjögren's Syndrome, Small Fiber Neuropathy, Autonomic Dysfunction, Autoantibodies
- Trial name
- NEUROSS (NCT07917442)
- Testing
- Sudoscan testing
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sjögren's Syndrome
Exosomes in Patients With Ocular Involvement of Sjögren's Syndrome
This study is a single-center, multiple-dosing, prospective, nonrandom, single-arm trial.
- Trial name
- NCT07192666
- Testing
- Exosome Preparation
- Volunteers
- 12 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Xerostomia
Malic Acid in Treatment of Xerostomia
Background: xerostomia is a subjective sensation of dry mouth resulting from quantitative and /or qualitative changes of saliva.
- Trial name
- NCT04756986
- Testing
- malic acid
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Sjogren's Syndrome
Analyse of Inflammatory Activity of Sjögren's Syndrome on 68Ga-FAPI PET-CT
Sjögren's syndrome (SS) is a chronic autoimmune disease primarily affecting the salivary and lacrimal glands, leading to symptoms of dryness. Assessing the inflammatory activity is crucial for guiding treatment.
- Trial name
- NCT07062523
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Mouth Dryness, Nausea
Chewing Gum in Hemodialysis Patients
This study was conducted to evaluate the effect of chewing xylitol gum on thirst, dry mouth and nausea in patients undergoing haemodialysis.Patients undergoing haemodialysis often experience thirst, dry mouth and nausea.This was…
- Conditions
- Mouth Dryness, Nausea, Hemodialysis Complication, Nurse's Role
- Trial name
- NCT05241587
- Testing
- Gum Group:, Mouth Spray Group:
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Didem Sarımehmet
Dental Caries
SDF Application in Oral Cancer Patients to Prevent Dental Caries
The Texas A \& M College of Dentistry, with partner Texas Oncology-Baylor Charles A. Sammons Cancer-Center Radiation-Oncology, proposes to conduct a preliminary clinical study (NIH Stage 0) to pilot test a randomized clinical…
- Trial name
- NCT05403125
- Testing
- silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Texas A & M University Baylor College Of Dentistry
Sjogren Syndrome With Other Organ Involvement
Tacrolimus for Thrombocytopenia in SS
This 12-week randomized, open-label study evaluates the efficacy and safety of Tacrolimus for Sjogren's syndrome patients with thrombocytopenia.
- Trial name
- NCT05678335
- Testing
- Hydroxychloroquine, Tacrolimus
- Volunteers
- 54 people
- Sponsor
- Peking Union Medical College Hospital
Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye
Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease
The goal of this research is to determine if the Tangible Boost system adequately replenishes the Hydra-PEG coating on the surface of a rigid contact lens.
- Conditions
- Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye, Sjogren's Syndrome, Dry Eye
- Trial name
- NCT04313725
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Tangible Science
Xerostomia
Effectiveness of Three Different Oral Moisturizers in Palliative Care Patients.
This study compares the effectiveness of 3 different oral moisturizers; 17% watery solution of glycerol, OGT oral spray, Aequasyal, and a newly developed Product, Salient.
- Trial name
- NCT03400969
- Testing
- Glycerol 17%, Aequasyal (OGT), Salient (new product)
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Bergen
Systemic Sclerosis, Gougerot Sjogren Syndrome
Echo Systemic Sclerosis
Systemic sclerosis is an autoimmune connective tissue disease with undefined etiology and characterized by progressive fibrosis of the skin and major organs.
- Conditions
- Systemic Sclerosis, Gougerot Sjogren Syndrome, Sicca-Asthenia-Polyalgia Syndrome
- Trial name
- NCT03143413
- Testing
- Ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Head And Neck Cancer
Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia
The goal of this clinical research study is to learn if acupuncture can help to prevent xerostomia (dry mouth) and improve the quality of life in patients who receive radiation treatment to the head and neck.
- Trial name
- NCT01266044
- Testing
- Acupuncture - Group 1, Acupuncture - Group 2, Standard Care
- Where
- 2 sites in United States, China
- Volunteers
- 435 people
- Sponsor
- M.D. Anderson Cancer Center