Clinical trials: Xenograft
Class II Furcation Defect
Enamel Matrix Derivative and Xenograft for Mandibular Molar Furcation Defects
This randomized controlled clinical trial aims to compare two regenerative surgical approaches for the treatment of mandibular molar Class II furcation defects in patients with periodontitis.
- Trial name
- NCT07776756
- Testing
- Periodontal Regenerative Surgery With Xenograft and Enamel Matrix Derivative, Periodontal Regenerative Surgery With Xenograft and Collagen Membrane
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Symphysis Onlay Bone Graft, Platelet Rich Fibrin
Effect of Symphysis Onlay Bone Graft, Injectable Platelet Rich Fibrin (I-PRF) and Xenograft on Horizontal Alveolar Ridge Augmentation in Esthetic Zone
The aim of the study: was to evaluate whether mandibular symphysis Onlay autogenous bone graft mixed with Injectable PRF could offer any advantages for patients undergoing horizontal alveolar ridge widening regarding increase…
- Conditions
- Symphysis Onlay Bone Graft, Platelet Rich Fibrin, Xenograft, Horizontal Alveolar Ridge Augmentation
- Trial name
- NCT06388837
- Testing
- Injectable Platelet Rich Fibrin, Xenograft
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- October 6 University
Prostate Cancer
Personalized Mini-PDX for Metastatic CRPC
The investigators intend to use the Second-generation sequencing（NGS）and MiniPDX drug sensitivity models to guide the treatment decision-making for patients who were resistant to abiraterone, enzalutamide or other new…
- Trial name
- NCT03786848
- Testing
- MiniPDX Group
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University Second Hospital
Squamous Cell Tumors of the Head and Neck (HNSCC)
Development of Patient Derived Xenografts (PDXs) and Analysis of Tyrosine Kinase Receptor Expression in Patients With Squamous Cell Head and Neck Cancer (HNSCC) to Study Resistance Mechanisms Induced by Standard Therapy
Protocol TitleDevelopment of Patient-Derived Xenografts (PDXs) and analysis of tyrosine kinase receptor expression in patients with Head and Neck Squamous Cell Carcinoma (HNSCC) to study resistance mechanisms induced by standard…
- Trial name
- SPAR (NCT07471009)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Alveolar Ridge Augmentation
Vallomix Socket Preservation Study
This research aims to compare the effectiveness of two bone grafting materials on preserving jawbone integrity after tooth extraction.
- Trial name
- NCT06472453
- Testing
- Allograft/Xenograft, Allograft
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Clinical Efficacy
Ridge Preservation Comparing an Intrasocket Graft Alone to an Intrasocket Graft Plus a Facial Overlay Graft
The purpose of this study is to compare two methods of ridge preservation in the maxillary anterior esthetic zone to determine the best method to establish adequate bone and soft tissue to accommodate implant placement.
- Trial name
- NCT01431131
- Testing
- Intrasocket graft, Intrasocket plus facial overlay graft
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia
These laboratory trial studies the development and treatment of a mouse model for acute myeloid leukemia (AML) using samples from younger patients with AML.
- Trial name
- NCT01576185
- Testing
- laboratory biomarker analysis, quizartinib, sorafenib tosylate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
Socket Preservation
The Effectiveness of Hyaluronic Acid in Bone Regeneration
Bone loss due to resorption is commonly observed in the alveolar socket following tooth extraction. This situation makes it difficult to preserve sufficient bone volume that would allow for ideal implant placement in cases…
- Trial name
- socket healing (NCT07031895)
- Testing
- a bovine-derived graft/xenograft enriched with hyaluronic acid, a standart bovine-derived graft/xenograft
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Burns
Use of Nile Tilapia Fish Skin as a Xenograft for Burn Treatment: Phase III Study
The present study is a Phase III Randomized Clinical Trial aiming to evaluate the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive biological dressing in the treatment of superficial partial-thickness burns…
- Trial name
- NCT04202289
- Testing
- Nile Tilapia Fish Skin, Silver Sulfadiazine Cream 1%
- Where
- 2 sites in Brazil
- Volunteers
- 115 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Sticky Bone
Guided Bone Regeneration Using a Mixture of Autogenous and Xenograft Particulate Versus Patient-Specific Sticky Bone for Horizontal Anterior Maxillary Defect
This study aims to enhance healing while minimizing invasiveness and restoring tissues to their proper structure and function by using patient specific sticky bone that will enhance the soft tissue reaction and maintain the graft…
- Trial name
- NCT07113886
- Testing
- Mixture of Autogenous and Xenograft Particulates, Patient-Specific Sticky Bone
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Squamous Cell Carcinoma of the Head and Neck
Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer
The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to: generate a biobank of in vivo patient xenografts representing the different…
- Trial name
- UCL-Xenog (NCT02572778)
- Testing
- Local biopsy in the tumor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Bone Regeneration
Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
fourteen patients requiring extraction of one posterior tooth with lost buccal bone (>50%) confirmed preoperatively by Cone-beam computed tomography (CBCT) scans.
- Trial name
- NCT05791123
- Testing
- a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Future University in Egypt
Dental Implant
Mucograft Seal in ARP Follow-up
Rationale: Early implant placement with alveolar ridge preservation (ARP) using either a collagen matrix or a palatal graft rendered similar esthetic, clinical and PROMs to early implant placement without ARP, up to 1 year after…
- Trial name
- NCT05663385
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Ridge Preservation, Allografts
Comparison of Two Types of Bone Grafts in Patients Who Need One of Their Front Teeth Removed and Replaced With an Implant
The purpose of this study is to compare two different bone graft materials (freeze-dried bone allograft, FDBA and collagen-enriched bovine xenograft, CEBX) that are routinely used for preserving the remaining bone after…
- Conditions
- Ridge Preservation, Allografts, Extraction, Tooth, Xenograft
- Trial name
- FDBA or CEBX (NCT06722482)
- Testing
- FDBA, CEBX
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Bone Resorption
GBR and Autogenous Bone Chips
This study will be an open, prospective, split-mouth, randomised controlled clinical trial. A total of 14 patients searching for oral implant treatment and where a GBR procedure is indicated per implant treatment will be…
- Trial name
- NCT03946020
- Testing
- Guided bone regeneration with or without autologous bone
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alveolar Ridge Augmentation
Ridge Augmentation in Posterior Mandible Using Tunneling Technique With Amix of Autogenous Bone and Xenograft With and Without Collagen Membrane
aim Evaluation of the amount of bone gain following Ridge augmentation using tunneling technique in atrophic posterior mandibular ridges using anorganic bovine bone derived mineral mixed with particulated autogenous bone chips…
- Trial name
- NCT03712631
- Testing
- tunneling technique bone augmentation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Rotator Cuff Tear, Graft Complication
Arthroscopic Superior Capsular Reconstruction - Study of Different Types of Grafts
Multicentric prospective clinical and radiological comparative study of consecutive patients with irreparable rotator cuff tears to test the hypothesis that there are significant differences in the improvement of the clinical and…
- Trial name
- NCT03739749
- Testing
- Arthroscopic superior capsular reconstruction
- Where
- Portugal
- Sponsor
- Hospital de Egas Moniz
Diabetes Mellitus, Type 1, Hypoglycemia
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Islet Cell Transplantation, Type 1 Diabetes
- Trial name
- NCT06575426
- Testing
- OPF-310
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Otsuka Pharmaceutical Factory, Inc.
Head and Neck Squamous Cell Carcinoma
TumorGraft- Guided Therapy for Improved Outcomes in Head and Neck Squamous Cell Cancer- A Feasibility Study
Primary objectives: 1. Evaluate the feasibility of rapidly accruing 30 participants with recurrent metastatic head and neck squamous cell carcinoma for the development of patient derived xenographs (PDX) from fresh, real time…
- Trial name
- Xenograft (NCT02752932)
- Testing
- Drug testing on PDX per Investigator's choice (upto 4)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Immediate Implant Placement in the Esthetic Zone, NON-RESTORABLE TOOTH IN ESTHETIC ZONE
Hyaluronic Acid Combined With Xenograft Versus Xenograft Alone in Immediate Implant Placement
This randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of immediate implant placement using xenograft combined with hyaluronic acid versus xenograft alone in the esthetic zone.
- Trial name
- NCT07862686
- Testing
- Immediate implant placement, Xenograft, Hyaluronic Acid (0.2%)
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University