Clinical trials: Xenotransplantation
Xenograft Model
Xenograft and Posterior Mandibular Socket Filling
The aim of this study is to evaluate the volume of madibular bone after placement of a xenograft in a fresh extraction socket in human.
- Trial name
- Flapless (NCT02736773)
- Testing
- xenograft material to slow resorption
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier
Bone Healing
Maxillary Sinus Augmentation by Xenograft Mixed With Melatonin
The possibility of enhancing the bone substitute in the maxillary sinus by mixing it with the melatonin to allow proper implant placement in early stage .
- Trial name
- melatonin (NCT06736821)
- Testing
- Open sinus augmentation with melatonin gel mixed with xenograft, Open sinus augmentation with xenograft
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- rehab soliman
Alveolar Bone Resorption, Sequela
Bone Material Comparison in Maxillary Sinus Augmentation
Hard and soft tissue deficiencies of an alveolar ridge arise as sequelae of tooth extraction when socket preservation is not applied.
- Conditions
- Alveolar Bone Resorption, Sequela, Tooth Extrusion
- Trial name
- NCT04433117
- Testing
- Shefabone, Bio-Oss
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mohanad Al-Sabbagh
Parkinson's Disease
Investigation of the Safety and Efficacy of NTCELL® [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease
To assess the safety of xenotransplantation of NTCELL [immunoprotected (alginate-encapsulated) choroid plexus cells] in patients with Parkinson's disease, assessed over the duration of the study, by monitoring the occurrence of…
- Trial name
- NCT02683629
- Testing
- NTCELL Implantation
- Where
- New Zealand
- Volunteers
- 18 people
- Sponsor
- Living Cell Technologies
Maxillary Sinus
Comparison Between PEEK With Autogenous Bone Graft and PEEK With Xenograft in Maxillary Sinus Augmentation
Comparison Between PEEK With Autogenous Bone Graft and PEEK With Xenograft in Maxillary Sinus Augmentation
- Trial name
- NCT06521853
- Testing
- PEEK With Autogenous Bone Graft, PEEK With Xenograft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Implant or Graft; Rejection
Effect Of PRF Versus Xenograft In Closed Sinus Lift.
Indirect sinus lift with used PRF as a graft material versus xenograft
- Trial name
- NCT03684954
- Testing
- Prf
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mahmoud adel shaaban
Maxillary Sinus Floor Augmentation, Dental Implant
Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
- Conditions
- Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
- Trial name
- NCT06247098
- Testing
- Sinus Lift augmentation, Cone-beam computed tomography systems (CBCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Periodontal Pocket, Periodontal Bone Loss
Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets
To evaluate the clinical effect of site preservation after third molars extraction by using tooth extraction of third molars with site preservation using bio-oss and bio-guide in preventing the formation of deep periodontal…
- Conditions
- Periodontal Pocket, Periodontal Bone Loss, Impacted Third Molar Tooth
- Trial name
- NCT06318247
- Testing
- site preservation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Dental Implant
Mucograft Seal in ARP Follow-up
Rationale: Early implant placement with alveolar ridge preservation (ARP) using either a collagen matrix or a palatal graft rendered similar esthetic, clinical and PROMs to early implant placement without ARP, up to 1 year after…
- Trial name
- NCT05663385
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Breast Cancer
Estrogen Receptor-Positive Breast Cancer Patient-Derived Xenografts
The investigators will establish a platform at Dartmouth-Hitchcock Medical Center to generate novel models of estrogen receptor alpha-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer, which…
- Trial name
- NCT02752893
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Class II Furcation Defect
Treatment of Class II Mandibular Furcation Defects
The aim of this study is to investigate the clinical efficiency and radiographic outcomes following minimally invasive surgical technique with xenograft and i-PRF versus i-PRF in the management of class II furcation defects in…
- Trial name
- NCT07876973
- Testing
- Injectable-PRF (I-PRF), sticky bone (I-PRF+Xenograft)
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Immediate Implant Placement in Chronic Infected Socket
Efficacy of Mixture of Vancomycin With Xenograft for Immediate Implant Placement in Chronic Infected Socket
Adding local vancomycin to xenografts greatly benefits stability, bone density, and limits marginal bone loss in dental implants in infected socket.
- Trial name
- RCT (NCT07784075)
- Testing
- immediate dental implants Placement in Chronic Infected Socket
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Rotator Cuff Tear, Graft Complication
Arthroscopic Superior Capsular Reconstruction - Study of Different Types of Grafts
Multicentric prospective clinical and radiological comparative study of consecutive patients with irreparable rotator cuff tears to test the hypothesis that there are significant differences in the improvement of the clinical and…
- Trial name
- NCT03739749
- Testing
- Arthroscopic superior capsular reconstruction
- Where
- Portugal
- Sponsor
- Hospital de Egas Moniz
Socket Perservation
Clinical Comparison of Xenograft With Hydrogel Versus Xenograft Alone in the Socket Preservation After Tooth Extraction: A Randomized Controlled Clinical Trial
Clinical Comparison of xenograft with hydrogel versus xenograft alone in the socket preservation After tooth extraction: A Randomized controlled Clinical Trial The ideal scaffolds used for alveolar ridge preservation are supposed…
- Trial name
- NCT06957197
- Testing
- Hydrogel with xenograft, Xenograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Marginal Bone Loss in Socket Shield Technique
Evaluate Marginal B. Loss in Immediate Implant Placement in Maxillary Esthetic Zone Using Socket Shield Versus Xenograft
Anterior maxilla (Esthetic zone) is very challenging area because of thin buccal plate of bone. After tooth extraction physiological process occur causing alteration of bone and soft tissue so, delayed placement of implant lead…
- Trial name
- NCT03394625
- Testing
- Socket shield technique, using Xenograft material
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Posterior Maxilla Edentulous Patients With Insufficient Alveolar Bone Height
Sinus Floor Elevation Using Separately Two Different Xenografts - A Prospective Randomized Clinical Trial
The purpose of this study is to compare the regenerative results of using separately two different xenografts after two-step sinus floor elevation.
- Trial name
- NCT01781221
- Testing
- Alpha-Bio's GRAFT Natural Bovine Bone, Bio-Oss xenograft
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Precise Prediction of Therapy Efficiency
Evaluation of Consistency of PDX Model for Predicting Therapeutic Effect of Gastric Cancer
The goal of this study is to compare the tumor response in gastric cancer patients given neoadjuvant chemotherapy with the corresponding result obtained from zebrafish patient-derived tumor xenograft(PDX) model given the same…
- Trial name
- NCT05616533
- Testing
- biopsy of tumor before treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Alveolar Bone Loss, Bone Graft; Complications
Patient Satisfaction and Bone Gain Following Autogenous Particulate Sticky Bone Preparation With Xenograft Versus Without Xenograft for Grafting of Maxillary Anterior Knife Edge Ridge in Partially Edentulous Patients for Implant Placement
The aim is to evaluate the value and efficiency of sticky bone in the augmentation of alveolar ridge deficiency when being used with or without xenogenic bone graft for esthetic implant placement.
- Trial name
- NCT03556111
- Testing
- Sticky bone augmentation
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Immediate Implant Placement
Effect of Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant
The objective of this study will be to compare between Immediate Implant grafted with xenograft and Alb-PRF gel versus xenograft with L-PRF.
- Trial name
- NCT06863051
- Testing
- Immediate Implant Placement and Alb-PRF, Immediate Implant Placement and L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Closed Sinus Lift, Apigenin Loaded Scaffold
Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold
aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.
- Trial name
- NCT07678749
- Testing
- sinus lifting
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University