Clinical trials: Zinc Deficiency
Critical Illness, Nutritional Deficiency
Trace Element Repletion Following Severe Burn Injury
Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome.
- Conditions
- Critical Illness, Nutritional Deficiency, Trace Element Deficiency, Burn Injury
- Trial name
- NCT03204669
- Testing
- Trace elements replacement
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sickle Cell Disease, Zinc Deficiency
Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya
Zinc is a nutritionally essential trace element found in previous studies to reduce growth retardation and improve immune function, which may also result in decreased incidence of infectious diseases including malaria, pneumonia…
- Conditions
- Sickle Cell Disease, Zinc Deficiency, Infection
- Trial name
- NCT03293641
- Testing
- Zinc Sulfate Tablets, Standard of Care
- Volunteers
- 40 people
- Sponsor
- Lucas Otieno Tina, MD MSc
COVID, Zinc Deficiency
Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women
Zinc d vitamin and b12 serum levels in covid-19 positive pregnants will be compared in terms of patients' responses to computed tomography and treatment.
- Conditions
- COVID, Zinc Deficiency, Vitamin D Deficiency
- Trial name
- NCT04407572
- Testing
- Serum zinc, vitamin d vitamin b12 levels .
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Zinc; Deficiency With Anemia
Zinc and Iron in Children With Short Stature
Short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard zinc and iron have important role in growth for children
- Trial name
- zincandiron (NCT03131349)
- Testing
- serum zinc and iron
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
HIV
Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients
The purpose of the study is to evaluate the safety and feasibility of administering SB-728mR-HSPC after conditioning with busulfan.
- Trial name
- NCT02500849
- Testing
- SB-728mR-HSPC Infusion 3 days following busulfan conditioning
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- City of Hope Medical Center
HIV Infections, Substance-Related Disorders
Zinc Therapy in HIV Infected Individuals Who Abuse Drugs
Zinc deficiency is prevalent in HIV infected individuals who abuse drugs. The purpose of this study is to determine if zinc therapy will prevent immune failure in HIV infected individuals who abuse drugs and have low plasma zinc…
- Trial name
- NCT00149552
- Testing
- zinc
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- Florida International University
Fluoride Poisoning, Hemoglobin
Using Eggshell Calcium to Mitigate Fluorosis in Ethiopia
Mothers and young children in rural Ethiopia lack sufficient nutrition, and a compounding factor is presence of high levels of fluoride (> 5-10 mg/day) affecting body functions.
- Conditions
- Fluoride Poisoning, Hemoglobin, Underweight, Stunting
- Trial name
- NCT03355222
- Testing
- Promotion of chicken eggs
- Where
- Ethiopia
- Volunteers
- 270 people
- Sponsor
- University of Saskatchewan
Very Preterm Infants, Zinc Deficiency
Higher and Standard Doses of Enteral Zinc Supplementation in Very Preterm Infants
The goal of this randomized clinical trial is to compare the effect of higher (10 mg per day) versus standard (1 mg per day) doses of zinc supplementation The main questions it aims to answer are: Growth velocities and delta…
- Trial name
- ZnVeryPT (NCT06219525)
- Testing
- Higher dose of enteral zinc, Standard dose of enteral zinc
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Prince of Songkla University
Environmental Enteric Dysfunction, Zinc Deficiency
Effects of EED on Zn Absorption and Retention in Children From a MNP
The overall objective is to determine the impact of EED on total daily zinc absorption of young Bangladeshi children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient…
- Trial name
- ZEED2 (NCT02758444)
- Testing
- Micronutrient Powder (MNP) + 15 mg Zn, MNP + 10 mg Zn, MNP + 5 mg Zn
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vitamin A Deficiency
Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age
The primary purpose of this study is to determine whether daily consumption of orange-fleshed sweet potatoes increases the vitamin A status of Bangladeshi women of reproductive age.
- Trial name
- NCT00453648
- Testing
- White-fleshed sweet potatoes, Orange-fleshed sweet potatoes (boiled), Orange-fleshed sweet potatoes (fried)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
HIV, HIV Infection
Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects
This research study is being carried out to study a new way to possibly treat human immunodeficiency virus (HIV). The agent is called SB-728-T which are CD4+ T-cells obtained from an individual that are genetically modified at…
- Trial name
- NCT01252641
- Testing
- SB-728-T
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sangamo Therapeutics
Zinc Deficiency, Diarrhea
Water-based Zinc Intervention Trial in Zinc Deficient Children
The overall aim of this trial is to determine whether the use of the household-based water treatment device Life Straw Family (LSF) can be an effective strategy to improve zinc status and health status of vulnerable populations…
- Trial name
- NCT01472211
- Testing
- zinc enriching filter (LifeStrawFamily), disinfection tablets
- Where
- Benin
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Zinc Deficiency
Effects of Liquid Zinc Supplementation and Dispersible Zinc Tablets on Plasma Zinc Concentration
The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.
- Trial name
- NCT00944853
- Testing
- Liquid zinc syrup, Zinc tablet
- Where
- Burkina Faso
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitamin A Deficiency, Iron Deficiency
Effect Of Multiple Biofortified Food Crops On Micronutrient Status And Immune Function Among Indian Infants and Their Mothers
In this study, meals based on multiple food crops (containing either biofortified or commercially-available food crops) will be fed to young children in Madanapalle, Andhra Pradesh, India over a period of nine months to measure…
- Conditions
- Vitamin A Deficiency, Iron Deficiency, Zinc Deficiency
- Trial name
- MBFC (NCT02648893)
- Testing
- Multiple biofortified food crops (MBFC-Exp), Commercially available non-fortified food crops (MBFC-C)
- Where
- 2 sites in India
- Volunteers
- 200 people
- Sponsor
- Cornell University
HIV Infections
Evaluating the Safety and Pharmacokinetics of PC-1005 Administered Rectally to HIV-1 Seronegative Adults
The purpose of this study is to evaluate the safety and pharmacokinetics of PC-1005 gel when used as a rectal microbicide in HIV-uninfected men and women (cis or transgender) with a history of consensual receptive anal…
- Trial name
- NCT03408899
- Testing
- PC-1005 gel
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection, Alcohol Use
Zinc for HIV Disease Among Alcohol Users - an RCT in the Russia ARCH Cohort
This study is a double-blinded randomized controlled trial (RCT) to assess the efficacy of zinc supplementation vs. placebo among 250 HIV-infected Russians from the Russia ARCH Cohort, who are ART-naive at enrollment and have a…
- Trial name
- ZINC (NCT01934803)
- Testing
- Zinc gluconate
- Where
- Russia
- Volunteers
- 254 people
- Sponsor
- Boston Medical Center
Immunity, Diarrhea
A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial
Vitamin A deficiency in children is associated with increased mortality and morbidity due to respiratory tract and diarrhoeal infections.
- Conditions
- Immunity, Diarrhea, Respiratory Tract Infections
- Trial name
- NCT00374023
- Testing
- Zinc, or Vitamin A or both
- Where
- Bangladesh
- Volunteers
- 147 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Nutritional Deficiency
Zinc Bioavailability From Amaranth-enriched Maize Tortillas
Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common.
- Trial name
- NCT02208609
- Testing
- Day 1: Maize Tortillas with 20% Amaranth, Day 2 Maize Tortillas without 20% Amaranth
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Zinc Deficiency, Mother and Child Malnutrition
Multi-Omic Profiling of a Zinc-Biofortified Maize Intervention in Guatemalan Mothers and Children
A trial evaluating the systemic and ecological impact of zinc-biofortified maize consumption on cellular zinc status, inflammatory biomarkers, and gut microbiota composition in a cohort of Guatemalan mothers and children.
- Trial name
- NCT07585318
- Testing
- F3 Biofortified Maize, Conventional Maize
- Where
- Guatemala
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition of Central America and Panama