Clinical trials: asthma
Asthma
Effects of Macrolides on Asthma Control
Asthma is a common disease in Westernised societies, affecting up to 10% of the population. Corticosteroids are the most effective treatment for asthma but the therapeutic response varies considerably between individuals.
- Trial name
- NCT00852579
- Testing
- Azithromycin
- Where
- 2 sites in United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Euan J Cameron
Asthma, Acute Asthma
Budesonide for Emergency Treatment of Acute Wheezing in Children
The purpose of this study is to determine if adding nebulized budesonide to the systemic steroid for treatment of acute wheezing has any additive benefit in the emergency room.
- Trial name
- NCT00733317
- Testing
- 0.5 mg/ml budesonide nebules, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kecioren Education and Training Hospital
Asthma, Vitamin D Deficiency
Vitamin D Oral Replacement in Asthma
The overall objective of the study is to determine the pharmacokinetics of Vitamin D supplementation in children who have asthma and are overweight or obese.
- Conditions
- Asthma, Vitamin D Deficiency, Pediatric Obesity
- Trial name
- VDORA1 (NCT03686150)
- Testing
- Vitamin D3 oral regimen
- Where
- 15 sites in United States
- Volunteers
- 112 people
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Asthma
A Randomised, Double- Blind, Placebo Controlled, Cross-over Efficacy and Safety Comparison of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for Four Weeks in Patients With Moderate Persistent Asthma
Rationale for the current trial is to demonstrate 24 hour bronchodilator efficacy and safety of tiotropium 5 µg administered once daily (in the evening) which is regarded beneficial for the compliance and convenience of the…
- Trial name
- NCT01152450
- Testing
- Tiotropium 2.5 µg b.i.d, Tiotropium 5 µg q.d.
- Where
- 15 sites in Austria, Czechia and 3 more
- Volunteers
- 94 people
- Sponsor
- Boehringer Ingelheim
Cystic Fibrosis, Asthma
Project 2 Airway Potential Hydrogen (pH) in Asthma
This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug.
- Conditions
- Cystic Fibrosis, Asthma, Severe Persistent Asthma, Healthy
- Trial name
- NCT03617718
- Testing
- Glycine Buffer
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- Case Western Reserve University
HIV Infections, Hypertension
ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE
The goal of this study is to determine the effect of the ENHANCE intervention in improving clinical outcomes and evaluating the effects of the intervention on implementation processes and outcomes.
- Conditions
- HIV Infections, Hypertension, Diabetes Mellitus, Asthma
- Trial name
- ENHANCE (NCT06248190)
- Testing
- ENHANCE intervention (health systems)
- Where
- 32 sites in South Africa
- Volunteers
- 1,837 people
- Sponsor
- University of KwaZulu
Asthma
Learning Health System for Asthma
This study forms an initial phase of work aimed at developing a learning health system (LHS), whereby data relating to asthma is extracted from patient electronic health records (EHRs) across Scotland, analysed to explore…
- Trial name
- NCT03000491
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 750,000 people
- Sponsor
- University of Edinburgh
Asthma in Children
Role of Technology in Improving Asthma Management In School Staff
The Asthma First Aid Management for School Staff eBook has been developed for the purpose of providing a multimedia self-directed training resource for school staff.
- Trial name
- NCT03530813
- Testing
- Ebook Asthma First Aid in School Training, Face-To-Face Asthma First Aid in Schools Training
- Where
- Australia
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Sydney Children's Hospitals Network
Asthma
Implementing Pathways to Improve Pediatric Asthma Care
Background: Asthma affects nearly 10% of American children, and is a leading cause of pediatric emergency visits and hospitalizations.
- Trial name
- PIPA (NCT03736603)
- Testing
- PIPA Intervention Bundle 1, PIPA Intervention Bundle 2
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Allergic Asthma
Study to Evaluate the Safety and Efficacy TPI ASM8 in Subjects With Asthma
The researchers propose to study the airways of asthmatics given TPI ASM8 for 14 days, and examine the protective effects on allergen-induced bronchoconstriction, hyperresponsiveness and airway inflammation.
- Trial name
- NCT00550797
- Testing
- TPI ASM8
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Syntara
Asthma, Bronchial
The Effects of Exercise on Physiological and Psychological Parameters in an Asthmatic Population
Exercise has been shown to have extensive health benefits both in normally functioning adults as well as in adults with asthma. A program of regular aquatic exercise may have unique benefits in the asthmatic population because of…
- Trial name
- NCT00825903
- Testing
- Exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington State University
Asthma
Using Mobile Phones to Improve Adherence to Inhaled Steroids
This study has two main goals. The first goal is to test whether a mobile phone intervention can increase adherence to daily inhaled steroid medications in African American adolescents prescribed this type of medication by…
- Trial name
- ADEPT4 (NCT01710059)
- Testing
- Asthma Supervision, Mobile Phone, Inhaled Corticosteroid Mobile Phone Application
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rush University Medical Center
Asthma Chronic
Use of Aptar Digital Health's Respiratory Disease Management Platform for Asthma
The United Kingdom has a high prevalence of asthma (over 12%) and some of the worst health outcomes in Europe. The management of respiratory disease and associated patient outcomes has long been an area of focus and improvement…
- Trial name
- NCT06364527
- Testing
- Aptar Digital Health respiratory disease management platform
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- CoheroHealth
Severe Eosinophilic Asthma, Nasal Polyps
RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
The purpose of this observational study is to describe the population of patients with SEA + NP who have been prescribed FASENRA and assess available clinical outcomes for both NP and asthma.
- Trial name
- RANS (NCT05180357)
- Testing
- FASENRA(benralizumab)
- Where
- 45 sites in United States, France and 4 more
- Volunteers
- 273 people
- Sponsor
- AstraZeneca
Infection, Heart Failure
Prediction of 30-Day Readmission Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04849312
- Where
- 2 sites in United States
- Volunteers
- 372 people
- Sponsor
- Brigham and Women's Hospital
Asthma
The Leukotriene Modifier Or Corticosteroid or Corticosteroid-Salmeterol Trial
This research study will compare the treatment effects of three different asthma medications in asthma subjects whose asthma is well controlled when they take fluticasone, an inhaled corticosteroid.
- Trial name
- NCT00156819
- Testing
- fluticasone, montelukast, Fluticasone plus salmeterol
- Where
- 19 sites in United States
- Volunteers
- 500 people
- Sponsor
- JHSPH Center for Clinical Trials
Allergic Asthma
A Study to Evaluate the Safety and Efficacy of HAE1 in Subjects With Moderate to Severe Allergic Asthma
This is a Phase II, multicenter, randomized, double blind, placebo controlled, multiple-dose study designed to evaluate the efficacy, safety, and tolerability of subcutaneously administered HAE1 in subjects 12-75 years old with…
- Trial name
- NCT00406965
- Testing
- HAE1 (PRO98498)
- Volunteers
- 50 people
- Sponsor
- Genentech, Inc.
Bronchial Asthma (Only the Patients With Severe or Intractable Bronchial Asthma Which Could Not be Controlled With the Existing Therapy)
TEZSPIRE (Tezepelumab) Asthma Japan Post-Marketing Study (PMS)
The purpose of the investigation is to confirm the followings under the post-marketing actual long-term use of Tezspire. 1. Development of related AEs 2.
- Trial name
- NCT05729711
- Where
- 33 sites in Japan
- Volunteers
- 416 people
- Sponsor
- AstraZeneca
Severe Prednisone Dependent Eosinophilic Asthma
Benralizumab in Patients With Inadequate Response to Anti-IL5 Monoclonal Antibody Therapies
In severe prednisone-dependent eosinophilic asthma, Benralizumab would suppress airway eosinophilia that is not suppressed by either Mepolizumab or Reslizumab and this would be associated with greater asthma control
- Trial name
- NCT03470311
- Testing
- Benralizumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Asthma
Registry for Asthma Characterization and Recruitment 2
There is a need for people to take part in research studies to learn more about diseases and how to treat them. The Registry for Asthma Characterization and Recruitment 2 (RACR2) will create a database of participants with asthma…
- Trial name
- RACR2 (NCT02513264)
- Where
- 10 sites in United States
- Volunteers
- 1,384 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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