Clinical trials: asthma
Bronchial Hyperreactivity, Bronchial Asthma
Comparison of Two Methods of Bronchial Methacholine Provocation
This study is meant to compare two routine diagnostic approaches in patients with bronchial asthma. Patients are challenged with methacholine in order to measure their bronchial response.
- Trial name
- NCT00503659
- Testing
- Bronchial methacholine provocation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Status Asthmaticus
Effectiveness and Cost Study Comparing Two Ways to Deliver Albuterol for the Treatment of Asthma in the Hospital
This study will be conducted as a randomized, double blinded, controlled trial. The control group will receive albuterol delivered by a nebulizer along with placebo treatments delivered by a metered dose inhaler (MDI) with a…
- Trial name
- NCT00623688
- Testing
- Metered Dose Inhaler & Optichamber Advantage Valve Holding Chamber (VHC), Airlife Sidestream High Efficiency Nebulizer
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Akron Children's Hospital
Asthma
Follow-up of Mild Eosinophilic Asthma
Asthma is a chronic respiratory disease affecting approximately 10% of the population, the majority of patients with very mild to mild asthma.
- Trial name
- NCT04650503
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Laval University
Asthma
Improved Quality of the Treatment and Increased Compliance in Asthmatics Through the Dialog Tool Soren - Between Patient and Caregiver
The purpose of the study is to assess if a dialog tool can improve compliance and asthma control in patients with asthma.
- Trial name
- NCT00272727
- Testing
- Dialog tool for caregivers
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Asthma, Infertility, Female
Identifying Disease Mechanisms Underlying the Association Between Asthma and Infertility - The INFLammation Asthma Mechanism Endometrium (INFLAME) Study
To investigate if asthma affects the inflammatory balance of the endometrium and thereby interfere with implantation, as indicated by the characteristics of the inflammatory cells in the endometrium and airways in women with…
- Trial name
- INFLAME (NCT04626557)
- Testing
- biopsy
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Asthma
The Effect of Vitamin D Supplementation on the Pulmonary Functions of Adult Asthmatic Egyptian Patients
This study evaluates the effect of vitamin D supplementation in the form of Alfacalcidol on the the pulmonary function of adult asthmatic Egyptian patients
- Trial name
- NCT02747381
- Testing
- Alfacalcidol
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Cairo University
Asthma
Pulmicort Respules on Relapse Rates After Treatment in the ED
The purpose of this study is to see if the addition of budesonide to oral corticosteroids will result in a decrease in relapse rates compared to oral corticosteroids alone in children who are discharged from the ED after an…
- Trial name
- Budesonide (NCT00584636)
- Testing
- pulmicort respules
- Where
- United States
- Sponsor
- Phoenix Children's Hospital
Asthma
Geographic Modeling of Traffic and Asthma Rates
This study surveys the parents/guardians about symptoms and diagnosis of asthma in kindergarten and first-grade students in 13 schools around the city of Anchorage, Alaska.
- Trial name
- NCT00041834
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Pneumonia, Bronchiolitis
Diagnosing Pneumonia Under Low-resource Conditions
Pneumonia is the commonest cause of death in children worldwide, killing 1.5 million children under the age of 5 years, every year. This is more than the number of children dying from AIDS, malaria and tuberculosis combined.
- Conditions
- Pneumonia, Bronchiolitis, Asthma
- Trial name
- NCT01997047
- Where
- Canada
- Volunteers
- 502 people
- Sponsor
- University of British Columbia
Asthma
ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of ENV-294 in adults with moderate to severe asthma who are receiving background treatment with inhaled…
- Trial name
- NCT07301255
- Testing
- ENV-294
- Where
- 20 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enveda Therapeutics
Asthma
BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging
This study will assess the effects of benralizumab on airway dynamics in severe eosinophilic asthma in terms of quantitative computed tomography (CT)-derived measurements of pulmonary structure and function using the Functional…
- Trial name
- BURAN (NCT05552508)
- Testing
- Benralizumab
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 45 people
- Sponsor
- AstraZeneca
Asthma
Modification of Asthma With Soy Isoflavone
The purpose of this study is to determine if dietary supplementation with soy isoflavones in persistent asthma improves airway reactivity as determined by PC20 to methacholine.
- Trial name
- NCT00741208
- Testing
- Soy Isoflavone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Asthma
Effect of RNS60 on the Late Phase Asthmatic Response to Allergen Challenge
The study will investigate the effect of treatment with RNS60 for 21 days. Subjects' FEV1 will be measured after an inhaled allergen challenge at baseline and again after 21 days of treatment.
- Trial name
- NCT02422121
- Testing
- RNS60
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Revalesio Corporation
Asthma
Replication of the P04334 Asthma Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04892758
- Testing
- Formoterol fumarate 10 mcg, Mometasone furoate/formoterol fumarate combination MDI 200/10 mcg BID
- Where
- United States
- Volunteers
- 10,288 people
- Sponsor
- Brigham and Women's Hospital
Asthma, Mild Asthma
A Study To Investigate The Effect Of Inhaled Fluticasone Propionate On The Bronchial Responsiveness To Leukotriene D4 In Asthmatics Patients
Investigate if asthmatics treated with FLIXOTIDE (FP) 500 mcg BID during 14 days get reduced bronchial reactivity after inhalation of Leukotriene D4.
- Trial name
- NCT00453778
- Testing
- FLIXOTIDE Diskus 500 mcg (Fluticasone Propionate)
- Volunteers
- 14 people
- Sponsor
- GlaxoSmithKline
Asthma
Ozone and Rhinovirus-Induced Disease in Asthmatics
In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections.
- Trial name
- NCT00013715
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma Exacerbation
Asthma Exacerbation and Helium-3 MRI
The goal of this research is to use Helium-3 MRI to see the changes in airflow of the lungs at different times of an attack. These three stages are immediately after the attack, 1 month later and 4-6 months later.
- Trial name
- NCT00846014
- Testing
- Helium-3
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Asthma, Airway Inflammation
Pioglitazone Hydrochloride (Actos(Registered Trademark)) to Treat Asthma
This study will test whether pioglitazone hydrochloride (Actos (Registered Trademark) Registered Trademark) is effective for treating patients with asthma who do not respond to standard therapy.
- Conditions
- Asthma, Airway Inflammation, Airflow Obstruction, Airway Hyperactivity
- Trial name
- NCT00604578
- Testing
- Pioglitazone Hydrochloride
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
This is a study of amlitelimab for the treatment of participants with moderate-to-severe asthma. The study will have a double-blind treatment period until Week 24 for each participant and an open-label treatment period where each…
- Trial name
- RIVER-ASTHMA (NCT06033833)
- Testing
- Amlitelimab
- Where
- 68 sites in United States, Argentina and 12 more
- Volunteers
- 335 people
- Sponsor
- Sanofi
Allergy, Asthma
Early Origins of Allergy and Asthma
Birth cohort study with recruitment during pregnancy to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in…
- Conditions
- Allergy, Asthma, Food Allergy, Allergic Sensitisation
- Trial name
- ARIES (NCT04186949)
- Where
- Chile
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
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