Clinical trials: asthma
Severe Allergic Asthma
Nocturnal TLA for Severe Allergic Asthma After Withdrawal of Omalizumab Therapy
This is a randomized, controlled study with a 48-week treatment phase to determine the clinical efficacy of temperature controlled laminar flow device (TLA, Airsonett™) in the patients with severe allergic asthma who are…
- Trial name
- NCT03480815
- Testing
- Nocturnal Temperature Controlled Laminar Flow Device, None Device
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Asthma
Magnetic Resonance (MR) in Asthmatic Patients
Asthma is a disease of small airways. Affected areas have reduced lung ventilation causing reflex vasoconstriction. MR perfusion imaging of the lungs is a sensitive method of imaging zonal lung perfusion.
- Trial name
- NCT00188487
- Testing
- magnetic resonance imaging (MRI) of the thorax
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Asthma, Smoking Cessation
Pediatric Emergency Department Decision Support System to Reduce Secondhand Smoke
This two phase study will develop and evaluate a Pediatric Emergency Department (PED) Decision Support System (DSS)-Electronic Medical Records (EMR) System to facilitate the identification of smokers and the delivery of a Second…
- Trial name
- NCT02489708
- Testing
- Cessation Counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma
SOLO-Symbicort® in the Treatment of Persistent Asthma in Adolescents & Adults
The purpose of this study is to compare Symbicort Single Inhaler treatment with the Best Conventional Practice in patients with persistent asthma
- Trial name
- NCT00238784
- Testing
- Budesonide/formoterol Turbuhaler
- Where
- 3 sites in Canada
- Volunteers
- 1,300 people
- Sponsor
- AstraZeneca
Asthma
Inhaled Iloprost in Mild Asthma
The purpose of the study is to determine if inhaled iloprost given four times daily can improve symptoms and lung function in adults with mild asthma.
- Trial name
- NCT01209533
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University
Severe Eosinophilic Asthma
Real World Evidence of Benralizumab in Eosinophilic Severe AsThma in Russia (BEST)
Benralizumab is a humanised, afucosylated, monoclonal antibody against the interleukin (IL)-5 receptor (IL-5R) α subunit that induces direct, rapid, and near-complete depletion of eosinophils in blood, airway tissue, and bone…
- Trial name
- NCT05271526
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- AstraZeneca
COPD, Asthma
Is Patients With Pulmonary Disease Benefit a Program With Yogic Exercises?
Is Yogic Exercises (12 weeks) increasing respiratory function, functional capacity and quality of life in patients with obstructive lung diseases. With follow up after 6 months.
- Trial name
- NCT02233114
- Testing
- Yogic exercises, Physiotherapy
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Asthma
An Effectiveness Study Comparing Fluticasone Furoate (FF, GW685698)/Vilanterol (VI, GW642444) With Standard Treatment in Asthma
This study is designed to compare the effectiveness and safety of Fluticasone Furoate/Vilanterol Inhalation Powder (100mcg Fluticasone Furoate ((FF), GW685698)/25mcg Vilanterol ((VI), GW642444) or 200mcg Fluticasone Furoate…
- Trial name
- NCT01706198
- Testing
- fluticasone furoate + vilanterol, inhaled corticosteroid with or without a long acting beta2-agonist
- Where
- 180 sites in United Kingdom
- Volunteers
- 4,233 people
- Sponsor
- GlaxoSmithKline
Severe Asthma
Real Life Experience Survey of Dupilumab in the Netherlands
Rationale: Dupilumab has proven to be effective and safe in several large randomized controlled trials. However, study populations in RCT's represent only a small proportion of severe asthma patients treated in real life…
- Trial name
- RELYonDupi (NCT05331755)
- Testing
- Dupilumab
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Gert-Jan Braunstahl
Asthma
XC8 Safety, Tolerability and Pharmacokinetics in Healthy Volunteers
A double-blind, randomized, placebo-controlled, Phase I clinical study of the safety and tolerability of increasing doses of XC8 after single and repeated oral administration in healthy volunteers.
- Trial name
- NCT03441815
- Testing
- XC8
- Where
- Russia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PHARMENTERPRISES LLC
Asthma, Obstructive Sleep Apnoea (OSA)
Is Asthma in Subjects With Obstructive Sleep Apnoea (OSA) Due to Dysanapsis
Intention to review patient letters from sleep clinic to see if their lung function fit in with Dysynapsis in wheezing patients or if it is true asthma
- Conditions
- Asthma, Obstructive Sleep Apnoea (OSA), Dysanapis
- Trial name
- NCT04142905
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Asthma Childhood, Exercise
Active Airways for Children and Young People With Asthma
What is this study about? The investigators want to see if exercise and education sessions can help children and young people (aged 10-17) with asthma, manage the participants asthma better.
- Conditions
- Asthma Childhood, Exercise, Children
- Trial name
- NCT07643753
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, education
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Asthma, COPD
Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease
This study will investigate potential differences in how two puffs of salbutamol protects airway smooth muscle from contracting in people with asthma and chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00440245
- Testing
- salbutamol
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Saskatchewan
Asthma Medication During Pregnancy
Adherence to Asthma Medication During Pregnancy
In the last decades, the prevalence of asthma increased substantially and is still increasing in many countries. Approximately 8% of pregnant women have asthma, making it one of the most common chronic conditions during…
- Trial name
- MAMP-Asthme (NCT06476041)
- Where
- France
- Volunteers
- 327 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Asthma, Rhinitis, Allergic
Molecular Allergen Component Resolved Diagnosis to Decide Immunotherapy
Allergen immunotherapy (AIT) is used for the control of allergic diseases that are not completely responsive to avoidance strategies and/or pharmacotherapy.
- Trial name
- CRD-AIT (NCT05448066)
- Testing
- Component resolved diagnosis, Standard diagnosis
- Where
- Portugal
- Volunteers
- 210 people
- Sponsor
- Universidade do Porto
AERD - Aspirin Exacerbated Respiratory Disease
Effect of Dupilumab on Aspirin Intolerance
To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab…
- Trial name
- NCT04442256
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pulmonary Disease, Chronic Obstructive
A Prospective Cohort Study of Asthma and COPD Overlap in Japanese COPD Patients Using the Diagnostic Criteria of The Japanese Respiratory Society
This study is a multicentered and non-interventional prospective cohort study. Study centers shall be the institutions where the examinations, adopted in the ACO diagnostic criteria9) from The Japanese Respiratory Society, are…
- Trial name
- ACO-Registry (NCT03577795)
- Where
- Japan
- Volunteers
- 710 people
- Sponsor
- AstraZeneca
Moderate Asthma
A Study to Assess Pharmacokinetics, Safety and Tolerability of Multiple Doses of CAT-354 in Subjects With Moderate Asthma
The study includes participants with moderate asthma who were randomly assigned to receive the study medication (CAT-354) or placebo.
- Trial name
- NCT00974675
- Testing
- CAT-354 1mg/kg, CAT-354 5 mg/kg, CAT-354 10mg/kg
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- MedImmune LLC
Asthma
A Study to Evaluate the Effect of Fluticasone/Formoterol Breath Actuated Inhaler (BAI) or Relvar® Ellipta® DPI on Ventilation Heterogeneity in Asthma
The purpose of this study is to demonstrate improvement of peripheral airway resistance (R5-R20) from baseline with fluticasone/formoterol breath actuated inhaler (BAI).
- Trial name
- NCT02753712
- Testing
- Fluticasone/Formoterol BAI, Fluticasone/Vilanterol DPI (Relvar Ellipta DPI)
- Where
- 16 sites in Australia, New Zealand and 3 more
- Volunteers
- 105 people
- Sponsor
- Mundipharma Research Limited
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