Clinical trials: asthma
Asthma
Technology-Assisted Stepped Care Study
The overall goal of this project is to demonstrate the feasibility, implementation, and preliminary efficacy of a technology-assisted stepped care (TASC) adherence-promotion intervention in adolescents with asthma.
- Trial name
- TASC Phase 3 (NCT03883594)
- Testing
- Technology-assisted Stepped-care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma
Single Ascending Dose Study of CM326 in Healthy Volunteers
Single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of CM326 in healthy volunteers.
- Trial name
- NCT04842201
- Testing
- CM326
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Asthma
Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma
The purpose of the study is to find out if taking vitamin D in addition to an asthma controller medication helps to prevent worsening of asthma symptoms and asthma attacks.
- Trial name
- VIDA (NCT01248065)
- Testing
- Vitamin D3, Ciclesonide
- Where
- 16 sites in United States
- Volunteers
- 408 people
- Sponsor
- Milton S. Hershey Medical Center
Asthma
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations.
- Trial name
- NCT06376045
- Testing
- Rocatinlimab
- Where
- 154 sites in United States, Argentina and 17 more
- Volunteers
- 317 people
- Sponsor
- Amgen
Asthma
Efficacy and Safety of Roflumilast in Patients With Asthma (BY217/M2-012)
The aim of the study is to compare the effects of oral roflumilast with placebo on lung function in patients with asthma.
- Trial name
- NCT00073177
- Testing
- Roflumilast
- Where
- 41 sites in United States, Argentina and 3 more
- Volunteers
- 819 people
- Sponsor
- AstraZeneca
Asthma
Strategies to Improve Asthma and Treatment of Asthma in Canadians
Our study will enroll 644 randomly-selected Canadians who have been diagnosed with asthma by a physician within the previous five years. It will be determined what diagnostic tests were initially performed to make this diagnosis.
- Trial name
- NCT01525381
- Where
- Canada
- Volunteers
- 701 people
- Sponsor
- Ottawa Hospital Research Institute
Exercise Induced Bronchospasm, Exercise Induced Asthma
Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)
Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy…
- Trial name
- IMT_EIB (NCT06336681)
- Testing
- PrO2Fit Device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
Asthma, Parkinson's Disease
Agricultural Health Study Follow-up
Background: The Agricultural Health Study (AHS) is looking at the long-term health effects of farming exposures including pesticides, crops, and animals.
- Trial name
- NCT01399411
- Where
- 3 sites in United States
- Volunteers
- 89,656 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma
A Study to Assess the Effect of QAW039 in Non-atopic Asthmatic Patients
The purpose of the study was to assess the clinical effect of QAW039 in non-atopic asthmatics taking low dose Inhaled Corticosteroid (ICS) as background therapy.
- Trial name
- NCT01836471
- Testing
- QAW039, Fluticasone 250 mcg, Fluticasone 100 mcg
- Where
- 76 sites in United States, Belgium and 8 more
- Volunteers
- 345 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Efficacy and Safety Study of Benralizumab Added to High-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled Asthma
The purpose of this study is to determine whether Benralizumab reduces the number of asthma exacerbations in patients who remain uncontrolled on high doses of ICS-LABA.
- Trial name
- NCT01928771
- Testing
- Benralizumab
- Where
- 275 sites in United States, Australia and 15 more
- Volunteers
- 2,681 people
- Sponsor
- AstraZeneca
Asthma
Effects of Budesonide & Budesonide/Formoterol on Smoking Asthmatic Subjects
A reduced response to inhaled corticosteroids (ICS) has been reported in smoking compared to non-smoking asthmatic patients. However, the comparative response to other currently prescribed medications such as combination therapy…
- Trial name
- D5890L00013 (NCT00691951)
- Testing
- budesonide and budesonide/formoterol
- Where
- 2 sites in Canada
- Sponsor
- Laval University
Pediatric Asthma, Uncontrolled Asthma
Systems Pharmacology Approach to Uncontrolled Pediatric Asthma
Background: Asthma is a heterogeneous respiratory disease and the most common chronic disease in children. A small subset of children has continuous poor asthma control despite appropriate adherence to asthma medication.
- Trial name
- NCT04865575
- Where
- 6 sites in Germany, Netherlands and 3 more
- Volunteers
- 145 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Asthma
Efficacy, Safety, Tolerability, and Pharmacokinetics of Indacaterol Maleate Via Concept1 or Simoon Devices
This study assessed the efficacy, safety, tolerability, and pharmacokinetics of two different formulations of indacaterol, one administered via the Concept1 device and one administered via the Simoon device.
- Trial name
- NCT01012739
- Testing
- Indacaterol 150 μg via the Concept1 dry-powder inhaler, Indacaterol 60 μg via the Simoon dry-powder inhaler, Indacaterol 120 μg via the Simoon dry-powder inhaler
- Where
- 4 sites in Germany, Netherlands and 1 more
- Volunteers
- 35 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Comparing Efficacy and Safety of Inhaled SNG001 to Placebo
When people with asthma get respiratory virus such as a cold or flu it often increases asthma symptoms. The investigators will test the study medication to find out if it can prevent the virus spreading from the nose to the…
- Trial name
- NCT01126177
- Testing
- Interferon beta 1a
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Synairgen Research Ltd.
Asthma in Children
Effect of a Daily Text Reminder on Asthma Medication Use, Symptom Control, and Lung Function in Children
The goal of this clinical trial is to learn if a daily text reminder ("AdhasText") can help children with asthma use their inhalers regularly, control their symptoms, and improve their lung function.
- Trial name
- NCT07053839
- Testing
- Daily Text Reminder
- Where
- Peru
- Volunteers
- 64 people
- Sponsor
- ROXANA AZNARAN TORRES
Asthma
A Study for Observing Severe Asthma in Patients Treated With Tezepelumab
A study involving primary data collection within real-world settings of participants who initiate treatment with tezepelumab for severe uncontrolled asthma.
- Trial name
- NCT05677139
- Testing
- None (Observational Study)
- Where
- 58 sites in Austria, Belgium and 7 more
- Volunteers
- 513 people
- Sponsor
- AstraZeneca
Smoking, Asthma
E-cigarettes for Harm Reduction in Adults With Asthma
Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma.
- Conditions
- Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- SWAP (NCT05278065)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brown University
Asthma, Bronchial Asthma
Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma
Approximately 5% of asthma patients suffer from severe asthma that is characterized by frequent asthma exacerbations resulting in significant morbidity and excessive utilisation of health care resources.
- Trial name
- TASMA (NCT02225392)
- Testing
- Bronchial thermoplasty, Alair system (Boston Scientific, USA)
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
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