Clinical trials: bipolar
Laparoscopic Appendectomy, Bipolar Diathermy
Use of Bipolar Diathermy VS Clips in Laparoscopic Appendectomy
Acute Appendicitis is the most frequent acute pathological abdominal illness needing immediate surgery. The laparoscopic appendectomy (LA) has become more popular and is advised as the first course of treatment, particularly for…
- Trial name
- NCT06826651
- Testing
- laparoscopic appendectomy, bipolar diathermy, clips closure
- Volunteers
- 100 people
- Sponsor
- Assiut University
Major Depressive Episode, Unipolar Depression
Ketamine As an Adjunctive Therapy for Major Depression (2)
Pragmatic, randomised, controlled, parallel-group, superiority trial of ketamine vs. midazolam as an adjunctive therapy for depression.
- Conditions
- Major Depressive Episode, Unipolar Depression, Bipolar Depression
- Trial name
- KARMA-Dep2 (NCT04939649)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 63 people
- Sponsor
- University of Dublin, Trinity College
Bipolar Depression
Efficacy of rTMS in Bipolar Depression
Bipolar Disorder is a common condition that is characterized by periods of mood elevation however periods of chronic and recurring depressive episodes are more common and can be severely disabling.
- Trial name
- rTMS-BD (NCT02749006)
- Testing
- iTBS repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- University of British Columbia
Schizophrenia Disorders, Bipolar Disorders
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry
Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are…
- Conditions
- Schizophrenia Disorders, Bipolar Disorders, Major Depression
- Trial name
- Mon Psy & Moi (NCT06818227)
- Where
- France
- Volunteers
- 23,660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Depressive Disorder, Major, Post Traumatic Stress Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression.
- Conditions
- Depressive Disorder, Major, Post Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT03367533
- Testing
- Ketamine, Perampanel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Bipolar Disorder (BD), Suicidality
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD).
- Trial name
- DEEPP (NCT05177146)
- Testing
- Intravenous Ketamine (IV)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Bipolar Disorder Type II, Mood Depressive Disorder
Exploration of Differences in Metabolite Concentrations by NMR Spectroscopy in the Ventral Striatum, Anterior Cingulate Cortex and Prefrontal Cortex in Euthymic Patients With Unipolar and Bipolar Type II Mood Disorders, as Well as in Healthy Subjects
The presented project is an open and controlled single-center prospective exploratory study, evaluating the metabolic concentrations in the ventral striatum (VS), the Anterior cingulate cortex (ACC) and the prefrontal cortex…
- Trial name
- RMN-UNIBI (NCT05650788)
- Testing
- NMR spectrometry
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Schizophrenia and Related Disorders, Bipolar Disorder
A Register Study of Effects Following Local Variation in Rates of Involuntary Care
Involuntary mental health care is permitted because it is believed to make people with severe mental disorders (SMD) better and prevent them from getting worse or even dying In this study we will investigate whether low levels of…
- Trial name
- NCT04655287
- Volunteers
- 21,759 people
- Sponsor
- University Hospital, Akershus
Bipolar Disorder
Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT)
Despite currently available treatment, a large proportion of patients with bipolar disorder (BD) suffer from affective symptoms, impaired psychosocial and cognitive function.
- Trial name
- NCT05035316
- Testing
- acetylsalicylic acid, Calcium
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Lars Vedel Kessing
Pediatric Bipolar Disorder, Pediatric OCD
Fluoxetine for Obsessive-Compulsive Disorder in Children and Adolescents With Bipolar Disorder
This will be a 12-week open-label pilot treatment study for children and adolescents (ages 6-17) who meet DSM-IV criteria for bipolar disorder (BPD) and obsessive-compulsive disorder (OCD) who are adequately mood stabilized on a…
- Trial name
- NCT00592852
- Testing
- fluoxetine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Mania, Sleep
Ottawa Sunglasses at Night for Mania Study
Mania is a serious condition. Symptoms of mania include decreased sleep, increased energy, changes in mood, thinking, and behavior.
- Conditions
- Mania, Sleep, Bipolar Disorder
- Trial name
- OSAN (NCT05206747)
- Testing
- Blue-blocking glasses, Lightly-tinted glasses
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- Ottawa Hospital Research Institute
Bipolar Disorder
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs
A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs.
- Trial name
- MOBILITY (NCT02515773)
- Testing
- Metformin, healthy lifestyle intervention (LIFE)
- Where
- 29 sites in United States
- Volunteers
- 1,565 people
- Sponsor
- Melissa Delbello
Schizophrenia, Schizoaffective Disorder
Lifestyle Intervention for Young Adults With Serious Mental Illness
This is a four year project evaluating the effectiveness of a group-based lifestyle intervention (PeerFIT) supported by mobile health (mHealth) technology and social media compared to Basic Education in fitness and nutrition…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT02815813
- Testing
- PeerFIT, BEAT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Disorder
Bipolar Transcranial Alternating Current Stimulation (tACS)
The purpose of this clinical trial is to measure the safety and effectiveness of a non-invasive brain stimulation device called Transcranial Alternating Current Stimulation (tACS) in participants with bipolar disorder (BD).
- Trial name
- NCT05480124
- Testing
- tACS brain stimulation treatment
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Depression, Unipolar, Depression, Bipolar
BioClock: Bright Light Therapy for Depressive Disorders
Bright Light Therapy (BLT) is a proven treatment for depression in seasonal and non-seasonal depressive disorders, as well as bipolar disorder.
- Trial name
- NCT05958940
- Testing
- Bright Light Therapy, Blue Light Blocking Glasses
- Where
- 2 sites in Netherlands
- Volunteers
- 231 people
- Sponsor
- Universiteit Leiden
Schizophrenia, Schizoaffective Disorder
Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
Atypical antipsychotic medications, such as olanzapine, cause metabolic side effects, including weight gain, extra fat around the middle of the body, high blood sugar, and high cholesterol.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Obesity
- Trial name
- NCT00512070
- Testing
- olanzapine and melatonin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Bipolar Disorder
Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
This study is for subjects with a diagnosis of bipolar disorder who have depression at the time of recruitment. It involves brain imaging with an MRI (magnetic resonance imaging) and PET scan (positron emission tomography) and…
- Trial name
- NCT02473250
- Testing
- Fluoxetine, Citalopram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute
Bipolar, Manic
Effect of Blue Light Blocking on Reducing Manic Symptoms in Bipolar Disorder
This study will be a randomized controlled trial (RCT) measuring the efficacy of wearing blue-blocking glasses (orange glasses) on manic symptoms in a population of patients suffering from Bipolar Disorder (BD), hospitalized for…
- Conditions
- Bipolar, Manic, Bipolar Disorder (BD), Dark Therapy
- Trial name
- BLUME (NCT06748716)
- Testing
- Blue-blocking glasses, Clear glasses
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- Rayan NASSERDINE