Clinical trials: i-PRF
Endodontics, Regenerative Endodontic Procedures
The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
- Conditions
- Endodontics, Regenerative Endodontic Procedures, PRF, i-PRF
- Trial name
- NCT07721051
- Volunteers
- 60 people
- Sponsor
- Kırıkkale University
Periodontitis Stage III
Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis
The goal of this clinical trial is to learn if a treatment called injectable platelet-rich fibrin (i-PRF) helps improve gum health in people with a type of gum disease called Stage 3 Grade B periodontitis.
- Trial name
- NCT07029035
- Testing
- İnjectable platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Intrauterine Adhesions
Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) caused by endometrial basal layer injury can lead to reduced menstrual flow, infertility, recurrent pregnancy loss, and poor reproductive outcomes.
- Trial name
- IPRF-IUA (NCT07536971)
- Testing
- Injectable Platelet-Rich Fibrin, Sodium Hyaluronate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Apical Periodontitis, i-PRF
Effect of I-PRF Application on ALP and MMP-9 Levels in Teeth With Apical Periodontitis
The aim of this study was to evaluate the effect of injectable platelet rich fibrin (i-PRF) injection, in addition to routine root canal treatment, on alkaline phosphatase (ALP) and matrix metalloproteinase-9 (MMP-9) levels in…
- Conditions
- Apical Periodontitis, i-PRF, Biomarkers, MMP-9
- Trial name
- NCT07320898
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Symphysis Onlay Bone Graft, Platelet Rich Fibrin
Effect of Symphysis Onlay Bone Graft, Injectable Platelet Rich Fibrin (I-PRF) and Xenograft on Horizontal Alveolar Ridge Augmentation in Esthetic Zone
The aim of the study: was to evaluate whether mandibular symphysis Onlay autogenous bone graft mixed with Injectable PRF could offer any advantages for patients undergoing horizontal alveolar ridge widening regarding increase…
- Conditions
- Symphysis Onlay Bone Graft, Platelet Rich Fibrin, Xenograft, Horizontal Alveolar Ridge Augmentation
- Trial name
- NCT06388837
- Testing
- Injectable Platelet Rich Fibrin, Xenograft
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- October 6 University
Graft Shrinkage, Gingival Recession, Localized
Effect of i-PRF and LLLT on Free Gingival Graft Shrinkage
This randomized clinical trial aims to evaluate whether injectable platelet-rich fibrin (i-PRF) and low-level laser therapy (LLLT) can reduce graft shrinkage after free gingival graft procedures.
- Trial name
- NCT07303192
- Testing
- Free Gingival Graft (FGG), Injectable Platelet-Rich Fibrin (i-PRF), Low-Level Laser Therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Bone Density Increased
Radiographic Assessment of Bone Dimension Around Immediate Implants With FDBA and I-PRF vs FDBA Alone
The present study is a human, prospective, parallel, randomised controlled clinical trial conducted for radiographic assessment of bone dimension around immediate implants with FDBA and I-PRF vs FDBA Alone The trial is in…
- Trial name
- NCT06522321
- Testing
- i-PRF and FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Chronic Periodontitis (Disorder), Periodontitis
i-PRF & Root Surface Biomodification
This study is designed to evaluate a new method to improve healing in patients with gum disease (periodontitis). A total of 42 adults with gum pockets deeper than 5 millimeters will take part.
- Trial name
- iPRF-Perio (NCT07207668)
- Testing
- Open Flap Debridement (OFD), 24% EDTA Root Conditioning, Injectable Platelet-Rich Fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Halil Ata BIÇAKÇIOGLU
Isolated Intrabony Periodontal Defects in Patients With Periodontitis
Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects
The goal of this Clinical trial is to evaluate the clinical and radiographic outcomes of using entire papilla preservation technique with and without autogenous bone and injectable platelet rich fibrin in treatment of isolated…
- Trial name
- NCT06347263
- Testing
- Entire papilla preservation technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Periapical Diseases
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment.
- Trial name
- NCT07448571
- Testing
- Non-Surgical Root Canal Retreatment, Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Marmara University
Class II Division 1 Malocclusion
The Effect of Autologous Platelet Concentrations on Orthodontic Treatment Time
60 patients needed therapeutic extraction of the maxillary first premolars with subsequent retraction of the maxillary canines were divided to randomly three groups: (1) PRP group: Received PRP injections, (2) I-PRF group…
- Trial name
- NCT05335824
- Testing
- The platelet-rich plasma (PRP), The injectable platelet-rich fibrin (I-PRF) group, The control group
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Wound Heal
The Effects Of I-PRF On Gingivectomy and Gingivoplasty
The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery.
- Trial name
- NCT05871190
- Testing
- İnjectable platelet rich fibrin, Gingivectomy anad gingivoplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Crowding of Anterior Maxillary Teeth
Repeated Injections of i-PRF for Decreasing Root Resorption After the Orthodontic Treatment.
Mandibular incisor crowding is a frequent issue that prompts many adults to seek orthodontic treatment. The treatment may enhance patients' quality of life, facilitate dental plaque control, and improve the quality of periodontal…
- Trial name
- NCT07352241
- Testing
- 4-time i-PRF injection group, Saline injection
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Chronic Inflammatory Gingival Enlargement
Effect of I-PRF After Gingivectomy
The goal of this clinical trial is to evaluate the effect of injectable platelet-rich fibrin application on wound healing following gingivectomy or gingivoplasty.
- Trial name
- I-PRF (NCT07174934)
- Testing
- application of injectable platelet-rich fibrin on the wound area .
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontoclasia, Gingiva; Injury
Use of Injectable-platelet-rich-fibrin (I-PRF) to Thicken Gingival Phenotype
The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival…
- Conditions
- Periodontoclasia, Gingiva; Injury, Condition, Blood Clot
- Trial name
- NCT03274674
- Testing
- I-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Wound Healing, Tooth Extraction Site Healing
Effect of Injectable Platelet Rich Fibrin (i-PRF) on Extraction Socket Healing: A Split-Mouth Randomized Study.
The aim of this study is to compare extraction socket healing (SH) following surgical extraction of lower third molars (LTMs) with and without the application of injectable platelet rich fibrine (i-PRF).
- Trial name
- (i-PRF) (NCT07257328)
- Testing
- Surgical extraction of lower third molars.
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Symptomatic Irreversible Pulpitis
Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis
Root canal therapy (RCT) is a classical and effective treatment that is currently utilised in dental practice, offering high success rates for pulp and periapical diseases; however, teeth after RCT are susceptible to altered pulp…
- Trial name
- NCT06525844
- Testing
- regenerative endodontic therapy using I-PRF, blood clot
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Lichen Planus
Use of Injectable Platelet Rich Fibrin in Lichen Planus
Platelet Rich Fibrine (PRF), which promotes wound healing by supporting angiogenesis, immunity and epithelial proliferation phases.
- Trial name
- NCT03265093
- Testing
- Platelet Rich Fibrin Injection, Corticosteroid
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Periodontal Diseases
Low-Level Laser Therapy and Injectable Platelet-Rich Fibrin for Thin Gingival Phenotype.
Management of thin gingival phenotype using non-surgical methods (injection of liquid platelet rich fibrin and exposure to low level laser therapy
- Trial name
- NCT06756854
- Testing
- Biologic Agent: injectable platelet rich fibrin., injecable platelet rich fibrin, and low level laser therapy radiation.
- Where
- Egypt
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Peridontal Disease
Efficacy of Injectable Platelet-rich Fibrin Versus Platelet-Rich Plasma As Adjunctive to Scaling and Root Planning in Non-surgical Periodontal Therapy of Periodontitis Patients
The study aims to evaluate the Efficacy of Injectable Platelet-rich Fibrin versus Platelet-Rich Plasma as adjunctive to scaling and root planning in non-surgical periodontal therapy of Periodontitis patients (Randomized…
- Trial name
- PRP-IPRF (NCT06685393)
- Testing
- Platelet rich plasma (PRP), INJECTABLE PLATELET RICH FIBRIN(I-PRF)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ELsabbahy Ahmed Mohamed Youssef