Clinical trials: mNGS
Bacterial Infections
Evaluation of a mNGS Workflow for Infection Diagnosis Using Oxford Nanopore Sequencing.
This is a laboratory evaluation of a new testing methodology for microbiological diagnosis, whereby participant samples received as part of routine care will be divided between the standard diagnostic pathway and this new…
- Trial name
- NCT04864873
- Testing
- Metagenomic next generation sequencing using Oxford Nanopore, Standard microbiological diagnostic pathway
- Where
- New Zealand
- Volunteers
- 400 people
- Sponsor
- Capital and Coast District Health board
Acute Respiratory Infection, Severe Pneumonia
Early Identification and Severity Prediction of Acute Respiratory Infectious Disease
Early identification and Severity prediction of Acute Respiratory infectious disease has become a top priority for clinicians at department of infectious and respiratory diseases after COVID-19 broke out.
- Conditions
- Acute Respiratory Infection, Severe Pneumonia, Next Generation Sequencing, Multiplex PCR
- Trial name
- ESAR (NCT04955756)
- Testing
- mNGS, Multiplex PCR
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- Huashan Hospital
Sepsis
mNGS vs Culture Critically Ill Patients
mNGS is popular in research and recently it has been used clinically to detect microbes in the blood or other secretion in infected patients for quicker ,broad and accurate detection of microbes.
- Trial name
- NCT03760315
- Testing
- blood mNGS (IDSeqTM Ultra); blood Culture
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Southeast University, China
Invasive Fungal Disease, Lung Transplant Recipients
Assessing Diagnostic Methods for Invasive Fungal Disease in Lung Transplant Recipients
This study aims to assess the diagnostic performance of different tests, including metagenomic next-generation sequencing (mNGS), real-time PCR, galactomannan assay, and lateral-flow device tests, in detecting invasive fungal…
- Conditions
- Invasive Fungal Disease, Lung Transplant Recipients, Invasive Pulmonary Aspergillosis, Pneumocystis Jirovecii Pneumonia
- Trial name
- NCT06654076
- Volunteers
- 109 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pneumonia
M-ROSE Combined With mNGS in Severe Hospital-acquired Pneumonia
The purpose of this study is to determine the value of M-ROSE（microbiological rapid on-site evaluation）in severe hospital-acquired pneumonia.
- Trial name
- NCT05300776
- Testing
- M-ROSE analysis
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Chinese PLA General Hospital
Infection
Anti-infection Therapy Based on mNGS Etiological Diagnosis and Infection After Liver Transplantation
Liver transplantation is the most efficacious treatment for end-stage liver disease; however, postoperative infection remains a major complication and leading cause of recipient mortality.
- Trial name
- NCT06212115
- Testing
- mNGS
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shenzhen Third People's Hospital
Diabetes Mellitus, Pulmonary Infection
Study on Diagnosis Value of mNGS Technology Among Diabetic Patients With Pulmonary Infections
Focusing on patients with diabetes complicated with pulmonary infection, the purpose of this study is: 1) to identify the epidemiology, etiologic spectrum and status of diagnosis and treatment; 2) to explore the lower respiratory…
- Trial name
- NCT05552872
- Testing
- mNGS, IDSeq UltraTM
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
mNGS
mNGS Was Applied to the Study of Pathogen Identification, Precision Medication and Efficacy Evaluation of Infected Patients
1) prospectively collected the patients with the proposed infection, confirmed the infection or excluded the infection through mNGS detection combined with traditional pathogen detection methods and clinical characteristics…
- Trial name
- NCT04310657
- Testing
- mNGS
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Hematological Malignancies, Invasive Fungal Disease
mNGS for IFD in Patients With Hematological Malignancies
Invasive fungal disease (IFD) refers to an infectious disease caused by fungi invading the human body, growing and reproducing in tissues, organs, or blood, and leading to inflammatory responses and tissue damage.
- Trial name
- NCT07763184
- Testing
- metagenomic next-generation sequencing
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Severe Acute Respiratory Infection, Community-acquired Pneumonia
mNGS -Guided Antimicrobial Treatment in Early Severe Community-Acquired Pneumonia Among Immunocompromised Patients
Severe Community-acquired pneumonia (SCAP) is a leading global infectious cause of intensive care unit (ICU) admission (approximately 20%-30%), and the primary reason of mortality and morbidity in immunocompromised patients.
- Conditions
- Severe Acute Respiratory Infection, Community-acquired Pneumonia, Respiratory Tract Infections, Pneumonia
- Trial name
- MATESHIP (NCT05290454)
- Testing
- mNGS-guided treatment
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Qilu Hospital of Shandong University
Urinary Tract Infections, Sequelae of; Infection
mNGS for Therapy of Urinary Infectious Diseases
Urinary tract infection is a common infectious disease in clinic. Although urinary tract infection can be initially diagnosed by clinical sign and symptom, signs and urine routine, the application of appropriate antibiotic…
- Trial name
- PGS-U-UTI&UC (NCT05624476)
- Testing
- mNGS of urine cell-free DNA
- Volunteers
- 72 people
- Sponsor
- Shanghai Changzheng Hospital
Acute Myeloid Leukemia, Adult
Investigation of the Gut Microbiota in Acute Myeloid Leukemia Receiving Two Different Induction Therapies
In this observational single-center cohort study, metagenomic Next-Generation Sequencing (mNGS) will be used to investigate the features and changes of gut microbiota in acute myeloid leukemia (AML) patients during the treatment…
- Conditions
- Acute Myeloid Leukemia, Adult, Gut Microbiota, Infections
- Trial name
- NCT05123352
- Testing
- collection of biological samples and clinical data
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Pulmonary Infection
mNGS for Detection of Pathogens for Pulmonary Infection
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases.
- Trial name
- NCT03798925
- Testing
- None Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Invasive Pulmonary Fungal Disease
Blood mNGS for Diagnosing Invasive Pulmonary Fungal Disease in Hematologic Patients
The goal of this clinical trial is to learn whether a blood test called metagenomic next-generation sequencing (mNGS) can help diagnose invasive pulmonary fungal disease in patients with blood disorders.
- Trial name
- NCT07511595
- Testing
- Blood microbial metagenomic next-generation sequencing (mNGS)
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Central Nervous System Infection
Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection
Delve Bio, Inc. is a developer of novel mNGS tests with the goal of aiding in the diagnosis of infectious diseases in several clinical indications that may not have alternative traditional diagnostic methods routinely available.
- Trial name
- IMPACT (NCT07435649)
- Testing
- Delve Detect CSF mNGS Test, Real-World Data
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Delve Bio, Inc.
CMV Infection, Hematopoietic Stem Cell Transplantation
Letermovir for the Prevention of CMV Infection in HSCT Recipients Based on the Outcome of mNGS
Letermovir for the Prevention of CMV Infection in HSCT Recipients Based on the Outcome of mNGS
- Trial name
- NCT06021210
- Testing
- Letermovir Pill
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Pulmonary Infection
The Value of mNGS in Diagnosis of Pulmonary Infection
Retrospective analysis of clinical data from 50 hospital-admitted patients with suspected pulmonary infection (as judged by clinical manifestations and imaging findings) was performed on study participants who had collected two…
- Trial name
- NCT06307405
- Testing
- next generation sequencing
- Volunteers
- 50 people
- Sponsor
- Yunfeng Hou
Respiratory Syncytial Virus Infection, Respiratory Syncytial Virus Infections
Genotype and Disease Burden of RSV in Older Vietnamese Adults (RSV: Respiratory Syncytial Virus )
This observational, prospective, multicenter study aims to estimate the proportion of RSV infection in adults aged 60 years and older hospitalized due to acute respiratory infections or exacerbation of cardiopulmonary disease.
- Trial name
- RSV-VN-Elderly (NCT07239583)
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- Tam Anh Research Institute
Central Nervous System Infections
Economic Impact of mNGS on Diagnosis of Post-neurosurgical Central Nervous System Infection
The aim of the current study was to assess the economic impact of using metagenomic next-generation sequencing (mNGS) versus traditional bacterial culture directed CNSIs diagnosis and therapy in post-neurosurgical patients from…
- Trial name
- mNGS (NCT05887037)
- Testing
- mNGS, The traditional microbiological cultures
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Jian-Xin Zhou
Lung Infection
Next-generation Sequencing Technology in the Clinical Application of Respiratory Specimens
Obtain the performance parameters and clinical consistency of mNGS and tNGS technologies in the pathogen diagnosis of lower respiratory tract specimens from patients with severe pulmonary infections, to provide a reference basis…
- Trial name
- NCT07191080
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Bin Zhang