Clinical trials: mTBI
Brain Injuries, Traumatic, Concussion, Mild
Validation of Brain Function Assessment Algorithm for mTBI/Concussion
This study is Part 2 of data collection from 13-25 years old subject population for validation of previously derived algorithms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- CAS13-25V (NCT03671083)
- Testing
- BrainScope Ahead 300iP
- Where
- 5 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Mild Traumatic Brain Injury
Deployment Related Mild Traumatic Brain Injury (mTBI)
The study will provide evidence on the long term outcomes of mTBI in service members returning from Afghanistan and Iraq. In addition, the study will provide evidence on mTBI incidence, and symptom patterns.
- Trial name
- NCT01847040
- Where
- 2 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Mild Traumatic Brain Injury, Brain Concussion
Testing mTBI in Athletes
This study will assess the effectiveness of a portable goggle system in the diagnosis of mild traumatic brain injury (mTBI) in athletes.
- Trial name
- NCT02486003
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- University of Miami
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Mild Traumatic Brain Injury, Concussion, Mild
Exercise as Concussion Therapy Trial- 2
This study is a Phase 2, open-label study of a therapeutic intervention (graded exercise)compared to a reference therapy (passive stretching) in patients who have sustained mTBI.
- Trial name
- ExACTT (NCT04578743)
- Testing
- Graded Exercise Therapy: ClearPlay(TM)
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANSwers Neuroscience, Inc.
Convergence Insufficiency
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI
The design of this project is a pilot study, a type of feasibility study conducted in preparation for subsequent RCTs that will assess the effectiveness of office-based vergence/accommodative therapy with movement (OBVAM) for…
- Trial name
- TBEye (NCT06848673)
- Testing
- Office-Based Vergence/Accommodative Therapy with Movement (OBVAM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salus University
Concussion, Brain, Motor Vehicle Accident
Research Evaluating Sports ConcUssion Events - Rapid Assessment of Concussion and Evidence for Return
RESCUE-RACER is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. The RESCUE-RACER programme evaluates motorsports competitors at baseline (CArBON) and post-injury (CARS).
- Trial name
- RESCUE-RACER (NCT03844282)
- Testing
- Clinical assessment (SCAT5), ImPACT, CANTAB
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Post-Concussion Syndrome, Post-Traumatic Headache
Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
The purpose of this study is to compare a 4-week, moderately intensive, lab and home-based aerobic exercise program versus exercise plus cognitive training.
- Conditions
- Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury
- Trial name
- NCT03674398
- Testing
- Exercise+CT, Exercise only
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Traumatic Brain Injury, Concussion, Mild
Rapid Biochemical Diagnostics of Traumatic Brain Injury
The objective of the study is to confirm the clinical relevance of the novel biomarker for traumatic brain injury (TBI) detection.
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Bone Fracture
- Trial name
- NCT03306563
- Testing
- Sample collection
- Where
- 3 sites in Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Brain Injury
Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI
Our central hypothesis is that chronic balance deficits after mild traumatic brain injury (mTBI) result from impairments in central sensorimotor integration (CSMI) that may be helped by rehabilitation.
- Trial name
- NCT02748109
- Testing
- Vestibular Rehabilitation + audio biofeedback, Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football…
- Trial name
- NCT04796207
- Testing
- Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Post-Traumatic Stress Disorders, Brain Injuries
Identifying Biomarkers That Distinguish PTSD and mTBI Using Advanced Magnetic Resonance Spectroscopy
The purpose of this study is to develop a new test to help diagnose mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in soldiers.
- Trial name
- NCT02927288
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Evaluation of Helmet Technology and Head Impact Exposure
The purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of football playing athletes grouped by helmet make and model.
- Trial name
- NCT03883451
- Testing
- Helmet Model
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild, Concussion, Intermediate
Assessment of Oculomotor, Vestibular and Reaction Time Response Following a Concussive Event
This study is designed to evaluate the use of a collection of tests that measure the eye response, balance, oculomotor and reaction time tests to aid in the diagnosis of mTBI.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NKI-RIF1 (NCT01832714)
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Neurolign
Mild Traumatic Brain Injury
Disparity Driven Vergence in Mild Traumatic Brain Injury (mTBI)
This study aims to determine the validity and safety of disparity driven vergence using a portable goggle system (I-PAS) using a pseudorandom ternary sequence of frequencies for testing.
- Trial name
- NCT03529799
- Testing
- I-PAS Goggles
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Post-Traumatic Stress Disorder, Blast Injury
Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder
The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic…
- Trial name
- ViRTICo-BP (NCT01990547)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Brain Injuries, Traumatic
mTBI Identification and Monitoring Through Retinal Scanning
Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or "HITT"), that detects ocular fixation and alignment using a binocular retinal scan.
- Trial name
- NCT06142435
- Testing
- Head and Intraocular Trauma Tool
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Brain Injury Traumatic Mild, Concussion, Brain
Dual-task Assessment and Rehabilitation for Individuals With Residual Symptoms After mTBI
This research aims to develop an intervention that combines mTBI-specific motor and cognitive challenges into a progressive and challenging rehabilitation program.
- Trial name
- NCT03478059
- Testing
- Cognitive and Motor Dual-task Intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Traumatic Brain Injury
Comparison of Brain Network Activation (BNA™) Analysis, Clinical Symptoms and Neuro-cognitive Performance in Concussed Children and Young Adults
The use of Event Related Potentials (ERP) and neurocognitive performance in patients following concussion has been examined previously in small cohorts and relatively long after concussion occurred.
- Trial name
- NCT01532271
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd