Clinical trials: miRNA
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
Mild Cognitive Impairment
Protein and microRNA Markers for Early Detection of Alzheimer's Disease
Blood will be harvested from three groups of people, normal control, patients with mild cognitive impairment (MCI) and patients with Alzheimer's disease (AD), 20 people per group.
- Trial name
- NCT03388242
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
COVID, Conjunctivitis
A Study to Assess the Virus RNA, and miRNA Levels Related to Viral Infection, and Inflammatory Response in Tears of Patients Affected by COVID-19 Disease
The aim of this study is to assess the virus RNA, and miRNA levels related to viral infection, and inflammatory response in tears of hospitalized patients with a diagnosis of COVID-19 with and without conjunctivitis and to…
- Trial name
- NCT04346160
- Testing
- Schirmer Test I
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Parkinson Disease
miRNAs Profiling in Parkinson's Disease
microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders.
- Trial name
- NCT03466723
- Testing
- biomarker identification in Parkinson disease
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Food Addiction, Sexual Addiction
Physiopathology of Behavioral Addictions and Biomarkers
The goal of this observational study is to evaluate the expression of miR-10a-5p in the blood in patients with sexual addiction or food addiction.
- Trial name
- MiRACle (NCT07830680)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Aortic Aneurysm
Blood microRNA Depression Change After DHCA
Collect the blood sample per-operation experience deep hypothermia cardiac arrest for aorta artery replacement surgery Collect the blood from the CPB machine and from intravenous injection tube which already set at different time…
- Trial name
- NCT03339414
- Testing
- collect blood
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- China International Neuroscience Institution
Gut Microbiota, microRNA
Human Gut Microbiota and microRNA Expression
In this study, stachyose was used as an intervention factor. We will evaluate changes in fecal gut microbiota and miRNA expression profiles in subjects under stachyose intervention
- Trial name
- NCT05392348
- Testing
- stachyose, Maltodextrin
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Osteoarthritis, Knee, Epigenetic Disorder
Exercise on microRNA in Osteoarthritis
The present study is a prospective cohort study. This study will be conducted to determine the change in miRNA levels with exercise in knee Osteoarthritis (OA) patients.
- Conditions
- Osteoarthritis, Knee, Epigenetic Disorder, Quality of Life, Depression
- Trial name
- NCT05869630
- Testing
- Exercise Programme, Experiments
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontitis, Adult
GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients
Objective: Periodontitis is a multifactorial disease that affects a wide range of populations. However, its pathogenesis remains unclear. miRNAs are now considered potential diagnostic markers for many inflammatory diseases.
- Trial name
- NCT06064799
- Testing
- miRNA-223 & -214 detection
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Healthy
Plant miRNAs In Human Plasma After Broccoli Consumption
Nutritional clinical study to evaluate the absorption and presence of exogenous miRNAs from broccoli in plasma and peripheral blood mononuclear cells (PBMCs) and to determine their possible implication in the modulation of fecal…
- Trial name
- NCT07456267
- Testing
- Broccoli consumption
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Breast Cancer
An In-situ Detection for MicroRNA
We designed a new in-site detection method for MicroRNA in the serum of patients with breast cancer.
- Trial name
- NCT06529614
- Testing
- In-situ detection for Micro-RNA
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Tooth Extraction Status Nos
MicroRNA and MicroRNA Inhibitors Socket Study, Pilot Clinical Trial
To evaluate the efficacy of locally delivering plasmid DNAs encoding microRNAs, and/or microRNA inhibitors, in the promotion of osteogenesis and modulation of the inflammatory response on the basis of different clinical…
- Trial name
- NCT02579187
- Testing
- tooth extraction, CBCT scan, Anesthesia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gustavo Avila-Ortiz DDS, MS, PhD
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for the early differentiation of Parkinson's disease (PD) from atypical parkinsonian…
- Conditions
- PARKINSON DISEASE (Disorder), Atypical Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
- Trial name
- BIOMARK-PS (NCT07604883)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Molecular and Cell Biology in Warsaw
Lung Cancer
Plasma microRNA Profiling as First Line Screening Test for Lung Cancer Detection: a Prospective Study
In the present project we propose a large prospective study in heavy smokers volunteers based on plasma miRNA profiling to assess its efficacy as a first line screening test for lung cancer detection.
- Trial name
- BIOMILD (NCT02247453)
- Testing
- screening
- Where
- Italy
- Volunteers
- 4,119 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Immune System
Effects of Almond Consumption on Innate and Adaptive Immune System
Almonds are a rich matrix of different nutrients with demonstrated benefits on immune system. This proposal examines the effect of regular consumption of almonds on innate and adaptive immune system in healthy individuals with…
- Trial name
- AlmondIS (NCT05026242)
- Testing
- Almond intervention, Control
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Periodontal Disease
Epigenetics, DNA Methylation Patterns and Periodontal Disease
The overall goal of this research is (1) to identify changes in gene expression and DNA methylation status in subjects who exhibit advanced chronic periodontal inflammation and (2) to identify microRNAs (miRNAs) and the…
- Trial name
- SZU (NCT01399034)
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Periodontal Diseases, Periodontitis
miRNAs in Periodontal Disease
It has been stated that microRNA (miRNA) play an important role in development, homeostasis and immune functions, and abnormal miRNA expression may cause faster disease progression.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT05046678
- Testing
- Control, Smokers with periodontally healthy, Non-smokers with gingivitis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University