Clinical trials: multiple sclerosis
Multiple Sclerosis, Social Cognition
Evaluation and Neural Basis of Communication in Patients With Multiple Sclerosis
Multiple sclerosis (MS) progressively leads to an increasing level of disability. That's why individuals faced with this chronic disease whose progression is unpredictable have to mobilize all their available resources.
- Conditions
- Multiple Sclerosis, Social Cognition, Neuropsychology, Psychological Therory
- Trial name
- COGNISEP (NCT02652013)
- Testing
- cognitive evaluation
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pôle Saint Hélier
MS (Multiple Sclerosis)
Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study
This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance…
- Trial name
- NCT01628276
- Testing
- Cog Rehab
- Where
- Iran
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sina Hospital, Iran
Multiple Sclerosis
DreaMS - Validation Study 1
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) causing focal lesions of demyelination and diffuse neurodegeneration in the grey and white matter of the brain and spinal cord, leading…
- Trial name
- NCT05009160
- Testing
- dreaMS App R2.1
- Where
- 6 sites in Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Research Center for Clinical Neuroimmunology and Neuroscience Basel
Multiple Sclerosis
The Minnesota Manual Dexterity Test As A Measure Of Hand Function in Multiple Sclerosis
The aim of the study is to report the results of manual dexterity using the Minnesota Manual Dexterity Test in people with Multiple Sclerosis.
- Trial name
- NCT04721340
- Testing
- Test Group, Control Grup
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Cognitive Change, Atrophy Brain
Physiologic Volume and Atrophy of Brain and Spinal Cord Measured by Magnetic Resonance Imaging
Spinal cord (SC) involvement is prevalent in multiple sclerosis (MS) and contributes importantly to disease progression. To be able reliably evaluate spinal cord volume and its changes in MS patients we need to understand…
- Conditions
- Cognitive Change, Atrophy Brain, Atrophy; Spinal Cord, Multiple Sclerosis
- Trial name
- NCT03706118
- Testing
- Magnetic resonance imaging
- Where
- Czechia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dana Horakova
Multiple Sclerosis
Description of Adherence to the Main Preventive Health Campaigns of Persons With Multiple Sclerosis
Persons with multiple sclerosis (PwMS) might be more susceptible to infections and cancers and chronic diseases than general population, not because of the presence of the disease itself, but in relation to some specific…
- Trial name
- preventionMS (NCT04930380)
- Testing
- phone interview
- Where
- 12 sites in Italy
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Siena
Multiple Sclerosis
[18F]PBR111 and Microglial Activation in Multiple Sclerosis
This is a study aimed to characterize [18F]PBR111 as an in vivo marker of microglial activation in Multiple Sclerosis. Regional binding of [18F]PBR111 will be quantified with PET in the brain of up to 24 patients with multiple…
- Trial name
- NCT01428505
- Testing
- [18F]PBR111
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pediatric-onset Multiple Sclerosis
Respiratory Functions in Pediatric-Onset Multiple Sclerosis
Pediatric-onset multiple sclerosis (POMS) is a chronic, autoimmune and inflammatory disease of the central nervous system that begins before the age of 18 years.
- Trial name
- NCT05123924
- Testing
- Evaluation of respiratory capacity, respiratory muscle strength and fatigue
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Relapsing Remitting Multiple Sclerosis
Comparative Bioavailability of BAFIERTAM™ (Monomethyl Fumarate) and Tecfidera® (Dimethyl Fumarate) in Healthy Subjects
The primary objective of this study was to assess the bioequivalence of the test product (Bafiertam; BLS-11; monomethyl fumarate) 190 mg versus Tecfidera® (dimethyl fumarate) 240 mg based on the Cmax and Area Under the Curve…
- Trial name
- NCT04570670
- Testing
- monomethyl fumarate 190 mg, dimethyl fumarate 240 mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Banner Life Sciences LLC
Multiple Sclerosis, Immune System Diseases
Mechanism of Action of Ocrelizumab in Multiple Sclerosis
Ocrelizumab is FDA approved for therapy of multiple sclerosis (MS). It depletes B cells and stops MS inflammation.
- Trial name
- NCT03344094
- Testing
- ocrelizumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Multiple Sclerosis, Upper Extremity Problem
Arm Swing During Walking in Early Multiple Sclerosis
Multiple sclerosis (MS) is the most common central nervous system inflammatory demyelinating disease which causes motor and sensory deficits, cerebellar symptoms, and balance problems.
- Conditions
- Multiple Sclerosis, Upper Extremity Problem, Gait Disorders, Neurologic
- Trial name
- NCT05821257
- Testing
- Evaluation of the arm swing during gait, Functional Tests
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis
Accurate Diagnosis of Multiple Sclerosis Using PET/MR
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system. Its main feature is progressive demyelination, which ultimately leads to axon damage and neuron loss.
- Trial name
- NCT04521439
- Testing
- 18F-florbetapir PET+MRSI
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
This study will look at the blood and cerebrospinal fluid of consented participants who either have early stage multiple sclerosis (clinically isolated syndrome) or who have later stage (secondary progressive multiple sclerosis)…
- Conditions
- Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Clinically Isolated Syndrome
- Trial name
- NCT01737372
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- John F. Foley, MD
Multiple Sclerosis
Safety of Switching From Rituximab to Ocrelizumab in MS Patients
This is a prospective between and within group observational study to determine differences in tolerability, immunogenicity and safety related outcomes for 100 multiple sclerosis (MS) patients who have been administered at least…
- Trial name
- NCT02980042
- Testing
- Ocrelizumab, Rituximab
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis, Stroke
An Assistive Powered Wheelchair: Stage 2 Trial
Preliminary evaluation of an obstacle alerting system to enhance the user's independent mobility by improving their confidence to drive and their safety in driving a powered wheelchair.
- Conditions
- Multiple Sclerosis, Stroke, Cystic Fibrosis, Motor Neurone Disease
- Trial name
- EDUCAT (NCT05292690)
- Testing
- Powered Wheelchair Obstacle Alerting System
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Multiple Sclerosis, Gait Disorders, Neurologic
Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis
The purpose of this study is to determine the utility of a performance measure for the dual-task of gait and considering people with multiple sclerosis have both cognitive and motor problems, the secondary aim of this study is to…
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Cognitive Impairment
- Trial name
- MS (NCT03536299)
- Testing
- Dual-task gait, Single-task gait
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Multiple Sclerosis, Relapse
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
This is a multi-center, prospective, controlled study. MS patients (1° group: 30 patients in relapse; 2° group: 30 patients in remission) and age/sex-matched healthy controls (3° group: 30 subjects) will be enrolled in the study.
- Trial name
- NCT04380220
- Testing
- Blood samples and processing
- Where
- 3 sites in United States, Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Multiple Sclerosis, Cognitive Rehabilitation
Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis
Despite the need for cognitive rehabilitation, there is a paucity of well-designed research studies to investigate treatment approaches or their effectiveness in MS.
- Trial name
- REACTIV (NCT01207856)
- Testing
- specific cognitive rehabilitation, non specific cognitive rehabilitation, no intervention
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers
Primary Objective: To assess the pharmacokinetic (PK) parameters of teriflunomide after a single oral dose of 14 mg administration in Chinese healthy subjects Secondary Objective: To assess the safety and tolerability after a…
- Trial name
- NCT02046629
- Testing
- Teriflunomide HMR1726, cholestyramine
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis, Relapsing-Remitting
Efficacy of Diet on Quality of Life in Multiple Sclerosis
The overarching goal of this project is to critically evaluate the efficacy of incorporating dietary guidance within multiple sclerosis (MS) care for improving long-term quality of life (QoL) compared to usual care.
- Trial name
- EDQ (NCT05007483)
- Testing
- BodyBio Balance Oil, Kirunal Fish Oil, BodyBio PC
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Terry L. Wahls