Clinical trials: multiple sclerosis
Multiple Sclerosis
Analyze the Myelin-TRAP as Diagnostic Tool in Multiple Sclerosis
The objective of this project is to characterize the response TRAP positive patients with Multiple Sclerosis (MS) and to evaluate the sensitivity and specificity of the method in order to develop a second time as a diagnostic…
- Trial name
- TRAP-Myéline (NCT01723631)
- Testing
- Trap Myelin Test
- Where
- 11 sites in France
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Multiple Sclerosis
ADAs to Alemtuzumab
The main aim is to quantify the changes in alemtuzumab antibody-anti-alemtuzumab over a 24 months period
- Trial name
- NCT06310343
- Testing
- Alemtuzumab
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Central Nervous System Disease, Multiple Sclerosis
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system.
- Trial name
- NCT00794352
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and results in a wide range of signs and symptoms including physical and cognitive problems.
- Trial name
- NCT02580435
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Idiopathic Inflammatory Demyelinating Disease, Multiple Sclerosis
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Idiopathic Inflammatory Demyelinating Disease (CBSinIIDD)
According to the records of traditional Chinese medicine, CBS has the following functions: clearing the heart, resolving phlegm, promoting bile secretion, and calming the nerves.
- Conditions
- Idiopathic Inflammatory Demyelinating Disease, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
- Trial name
- NCT06474520
- Testing
- Calculus bovis sativus (CBS)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Multiple Sclerosis
Analysis of a Biomarker Signature in Patients With Multiple Sclerosis (MS) Treated With Gilenya (FTY720)
This study investigates whether there is a link between disease activity/progression in patients receiving Gilenya and expression of a putative biomarker signature in patients with multiple sclerosis.
- Trial name
- MS (NCT02408380)
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University
Multiple Sclerosis
Role of Neuromuscular Junction Function in Motor Fatigue in Multiple Sclerosis
This pilot study will evaluate for the presence of neuromuscular junction (NMJ) defect in women with motor fatigue in multiple sclerosis by Single Fiber Electromyography (SFEMG) using the concentric needle electrode.
- Trial name
- NCT02418897
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
Motor Asymmetry in Progressive Multiple Sclerosis Patients
Project Rational A better understanding of the causes of physical disability is an important unmet need in progressive Multiple Sclerosis patients.
- Trial name
- MAP-MS (NCT04918225)
- Testing
- Magnetic Resonance Imaging, Neurological examination, Multiple Sclerosis Functional Composite
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
The investigators want to evaluate ovarian reserve concerning patients with multiple sclerosis, compared to a control group of healthy women. This study will include women from 25 to 35 years old.
- Trial name
- FEMINISEP (NCT05754593)
- Testing
- Anti-Mullerian hormone (AMH) level, Antral follicle count (AFC), Clinical assessment
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Sunlight-mediated Inter-organ Leukocyte Exchange
Ultraviolet B (UVB) irradiation induces regulatory immune cell types that may transmigrate from the skin to the blood and to the central nervous system and exert regulatory effects.
- Trial name
- SMILE (NCT05627609)
- Testing
- 311 nm narrowband UVB irradiation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Multiple Sclerosis
Chewing Under Dual-Tasking in MS
This study aims to investigate the effects of visual, auditory, and motor dual-task conditions on chewing performance in individuals with multiple sclerosis, compared with healthy controls.
- Trial name
- NCT07366216
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis
Muscle Architecture of Lower Extremity In Multiple Sclerosis
The aim of this study was to determine the muscle architecture of the lower extremity muscles (pennation angle, muscle fiber length and muscle thickness) in patients with multiple sclerosis.
- Trial name
- NCT03766698
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sanko University
Multiple Sclerosis, RRMS
Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis
The main purpose of this study is to assess whether hyperpolarized carbon imaging in relapsing remitting multiple sclerosis (MS) patients can be used to predict response to anti-CD20 disease modifying therapy.
- Conditions
- Multiple Sclerosis, RRMS, Relapsing Remitting MS
- Trial name
- MIIMS (NCT07510607)
- Testing
- HP 13C pyruvate injection, MRI Scanner
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ari Green
Sclerosis, Multiple, Cognitive Dysfunction
XO as a Screening Test of Cognitive Impairment in Multiple Sclerosis
Even at the disease onset, about 70% of patients with multiple sclerosis (MS) suffer from cognitive impairment that impacts quality of life.
- Trial name
- XO-SEP (NCT03999034)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
Investigating Indirect Mechanism of Neuroprotection of Tecfidera® (Dimethyl Fumarate) in RRMS and Progressive Patients
The purposes of this study is to identify types of bacteria that reside in the intestine of healthy individuals and compare them to individuals with Multiple Sclerosis (MS).
- Trial name
- NCT03092544
- Testing
- dimethyl fumarate
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Multiple Sclerosis Center of Northeastern New York
Multiple Sclerosis, Healthy Controls
Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and…
- Trial name
- NCT01845896
- Testing
- Training
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bert Op't Eijnde
Multiple Sclerosis
Effects of Head and Neck Cooling and Heating on Fatigue in Multiple Sclerosis and Healthy Men
Local head and neck cooling strategies can help reduce multiple sclerosis-related fatigue, while heating can exacerbate heat-related fatigue.
- Trial name
- NCT06370403
- Testing
- Cooling of the head and neck, Heating of the head and neck
- Where
- Lithuania
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD).
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, MOG Antibody-Associated Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NeuroDIP (NCT07902479)
- Testing
- Blood sampling and multi-omic profiling
- Where
- 5 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Multiple Sclerosis
Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects
This is a Phase 1, single-center, open-label, non-randomized study to assess the effects of CYP2C8 inhibition using gemfibrozil, and CYP3A4 and CYP2C8 induction using rifampicin on the pharmacokinetics of SAR442168 in healthy…
- Trial name
- NCT06064539
- Testing
- Tolebrutinib, gemfibrozil, rifampicin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis, Healthy
Walking Fatigability and Brain Activity in People With Multiple Sclerosis
Walking fatigability is a motor impairment happening in approximately 43.5% of people with multiple sclerosis (pwMS). Walking fatigability is defined as a decrease in 10% of distance walked, comparing the first minute with the…
- Trial name
- NCT06672484
- Where
- 3 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University