Clinical trials: n-3 Polyunsaturated Fatty Acids
Hypertension, Lipid Metabolism Disorders
Alpha-linolenic Acid and Blood Pressure
Rationale: Increased intakes of n-3 long chain polyunsaturated fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), mainly found in fatty fish, are recommended for the prevention of coronary heart disease.
- Trial name
- VASALA (NCT02243969)
- Testing
- Flaxseed oil, high oleic sunflower oil (HOSF)
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Osteoporosis
Investigation of the Effect of BONISTEIN(R) Bone Blend on Bone Mineral Density/Content and Biomarkers of Bone Health
The purpose of this study is to obtain information about the effect of a combination of genistein, PUFAs, vitamin K and D (BONISTEIN(R) bone blend) on bone health, determined as bone mass density/content and bone biomarkers after…
- Trial name
- NCT00698984
- Testing
- BONISTEIN(R) bone blend
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Muscle Strength, Cognitive Function
Fish Oil T Cell Function
The purpose of the study is to examine the effect of dietary n-3 polyunsaturated fatty acid supplementation on subjects' pan CD4+ T cell function, cognition, and muscle function.
- Trial name
- NCT02775084
- Testing
- Fish Oil, Olive Oil
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Overweight, Obesity
Fatty Acids During Pregnancy and Lactation and Body Fat Mass in Newborns
Pregnant and lactating women receive n-3 fatty acids starting from week 15 of gestation until 4 months post-partum (pp) in comparison to a control group, who only gets information about adequately healthy nutrition during…
- Trial name
- NCT00362089
- Testing
- Marinol D-40
- Where
- Germany
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sleep Deprivation
Study on the Mechanism of Central Obesity Induced by Sleep Restriction and the Therapeutic Effect of n-3 Polyunsaturated Fatty Acid: a Randomized, Double-blind, Placebo-controlled Trial (COSPA Study)
This randomized, double-blind, placebo-controlled trial aims to investigate whether n-3 polyunsaturated fatty acid (PUFA) supplementation attenuates abdominal visceral fat accumulation induced by experimental sleep restriction.
- Trial name
- NCT07897097
- Testing
- n-3 PUFA Supplementation, Experimental Sleep Restriction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Gestational Diabetes Mellitus, Neurodevelopmental Disorders
n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
This study aims to investigate the associations of maternal nutritional status during pregnancy and postpartum periods with postpartum abnormal glucose metabolism in Guangzhou pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Neurodevelopmental Disorders, Postpartum Abnormal Glucose Metabolism, Child Growth and Development
- Trial name
- NCT03023293
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,122 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Nutrition
Trial of Fish Intake Advice in Pregnancy
The overall goal of this project is to establish a pilot study to develop and refine an intervention to promote consumption of fish low in mercury and high in n-3 PUFA among pregnant women.
- Trial name
- NCT01126762
- Testing
- Dietary advice, Control
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Extracellular Vesicles; Generation and Function
Fish Oil-derived N-3 Polyunsaturated Fatty Acids and Extracellular Vesicles
N-3 polyunsaturated fatty acids (n-3 PUFA), which are abundant in oily fish and fish oils, have been suggested to play a role in reducing the risk of cardiovascular diseases (CVDs) by modifying a wide range of risk factors, such…
- Trial name
- HI-FIVE (NCT03203512)
- Testing
- Fish oil capsules, High-oleic safflower oil capsules
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Inflammation
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans
The overall goal of the research study is to determine whether a high-fat meal causes postprandial (after meal) inflammation, and whether eating n-3 polyunsaturated fatty acids (PUFAs) or blueberries that are rich in…
- Trial name
- NCT02472171
- Testing
- High saturated fat meal, blueberry powder and sunflower oil
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Hypertriglyceridemia
Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition
Hypertriglyceridemia is one of the most prevalent lipid profile disorders and is linked to a large proportion of mortality in Mexico and around the world.
- Trial name
- SALVIMEX (NCT07004777)
- Testing
- Isocaloric diet including chia and pumpkin seeds, Isocaloric diet
- Where
- Mexico
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Healthy
Does Consuming Modified Plant Seed Oil Containing Fish Oil Fatty Acids Act in the Same Way as Consuming Fish Oil?
Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week.
- Trial name
- NCT03477045
- Testing
- Single dose fish oil, Repeated dose fish oil, single dose Camelina seed oil
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Cardiovascular Diseases, Vasodilation
Effects of n-3 Polyunsaturated Fatty Acids and Antioxidants on Postprandial Hyperlipidemia and Vascular Function in Men
Diet has long been used as a way to provide enough nutrients to an individual in order to meet metabolic requirements. However, recent scientific advancements have suggested that beyond meeting nutrition needs, diet may also be…
- Trial name
- NCT00296595
- Testing
- Nutrition
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Laval University