Clinical trials: stroke
Stroke Volume Variation
Study of the Natural Variation in Strokevolume
We would like to investigate the natural variation in the strokevolume of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in strokevolume, after a…
- Trial name
- NCT00447200
- Testing
- Esophagus Doppler monitoring, Fluid optimization
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke, Cognitive Disorders
Post-stroke Cognitive Impairment and Dementia
Projections from epidemiological studies suggest that, among the Western adult population, one in three will present a cerebrovascular accident (stroke), severe cognitive disorders, or both.
- Conditions
- Stroke, Cognitive Disorders, Behavioral Disorders
- Trial name
- GRECogVASC (NCT01339195)
- Testing
- French adaptation of NINDS-Canadian Stroke Network battery
- Where
- 7 sites in France
- Volunteers
- 1,635 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke
An Open Label, Phase 1b, Ascending Dose Study of DM199
This is a Phase 1B study to assess the safety, tolerability and pharmacokinetics of DM199 in healthy volunteers. The study will be consist of two parts: Part A will focus on intravenous dosing and Part B will directly compare…
- Trial name
- NCT02868996
- Testing
- Recombinant human tissue kallikrein
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- DiaMedica Therapeutics Inc
Stroke, Healthy
Operant Conditioning for Neuromodulation
Emerging evidence demonstrates that animals and people can exert control over the level of excitability in spinal and corticospinal neural circuits that contribute to movement.
- Trial name
- NCT03461159
- Testing
- Operant conditioning of H-reflexes, Operant conditioning of motor evoked potentials
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stacey Dejong
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Myocardial Infarction, Ischemic Stroke
Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)
The aim of this study is to assess how long-term alcohol consumption influences health risks by emulating the Moderate Alcohol and Cardiovascular Health Trial (MACH15).
- Conditions
- Myocardial Infarction, Ischemic Stroke, Angina Pectoris, Coronary Revascularization
- Trial name
- NCT06583161
- Testing
- Moderate drinking, Quitting, Social drinking
- Volunteers
- 503,325 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Stroke
Clinical Reasoning Process of Physiotherapists When Observing Hemiplegic Gait
The goal of this study is to find out what clinical reasoning process physiotherapists undergo when observing hemiplegic patients gait.
- Trial name
- NCT02504073
- Testing
- No intervention
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Technical University of Bern
Stroke
Trunk Restraint Therapy in Post-stroke Patients.
The aim of this study was to evaluate the long-term effects of the task-specific training with trunk restraint comparing to the free one in post-stroke reaching movements.
- Trial name
- NCT02364141
- Testing
- Trunk restraint therapy, Trunk unrestraint therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Acute Coronary Syndrome, Stroke
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SP-8008
This is a single-centre, double-blind, randomised, placebo-controlled single oral-dose escalation study in healthy male subjects. It is planned to enrol approximately 48 subjects into up to 6 planned dose level cohorts.
- Trial name
- NCT04770194
- Testing
- SP-8008 Prototype Capsule A, SP-8008 Prototype Capsule B
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
MACE, Atrial Fibrillation (AF)
throMboembolic Risk Associated To High atrIal Fibrillation riSk
Cardiovascular diseases are the leading cause of mortality from treatable conditions in the European Union and the second from preventable causes, with a standardized mortality rate of 257.8 deaths per 100,000 inhabitants.
- Conditions
- MACE, Atrial Fibrillation (AF), Quality-adjusted Life-years, Electronic Health Records
- Trial name
- MATHIAS (NCT07441759)
- Testing
- AI_MATHIAS
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Stroke
Noninvasive Brain Stimulation for Stroke
Noninvasive brain stimulations will be used in acute and chronic stroke patients to improve a variety of functions.
- Trial name
- NIBSstroke (NCT01503073)
- Testing
- tdcs (ELDITH, Neuroconn, Ilmenau, Germany)
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Atrial Fibrillation
A Study to Investigate if Early Atrial Fibrillation (AF) Diagnosis Reduces Risk of Events Like Stroke in the Real-World
The primary objectives of this study are to identify and diagnose Atrial Fibrillation (AF), evaluate improvement in cardiovascular (CV) outcomes, improve direct oral anti-coagulant (DOAC) adherence and persistence, and better…
- Trial name
- NCT04276441
- Testing
- Heart healthy Engagement Program with the Apple Watch Series 5 or later, Anti-Coagulation Adherence Module with the Apple Watch Series 5 or later
- Where
- United States
- Volunteers
- 34,244 people, healthy volunteers welcome
- Sponsor
- Janssen Scientific Affairs, LLC
Stroke, Pain
Exercise Induced Hypoalgesia in Pain-free Stroke and Healthy Populations: a Cohort Study
Exercise has shown multiple beneficial effects in both healthy and post-stroke populations. One of these is the acute reduction in sensitivity to painful stimuli, called exercise-induced hypoalgesia (EIH).
- Conditions
- Stroke, Pain, Exercise Induced Hypoalgesia
- Trial name
- NCT07327593
- Testing
- Cardiovascular training
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuron, Spain
Parkinson Disease, Brain Tumor
Neuropsychology of Financial Capacity
The present project aims to investigate the financial capacity in patients diagnosed with Parkinson's Disease or parkinsonism, brain tumor (glioma or meningioma) and cerebrovascular lesion (stroke), in order to evaluate the…
- Conditions
- Parkinson Disease, Brain Tumor, Stroke
- Trial name
- NEUROFIN (NCT05791006)
- Testing
- Neuropsychological tests
- Where
- Italy
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aphasia, Stroke
Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning
This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction.
- Conditions
- Aphasia, Stroke, Gestures
- Trial name
- RIAB_GESTO (NCT07518563)
- Testing
- Person with Aphasia
- Where
- Italy
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke
Gait Training in Post-Stroke Hemiparesis Hemiparesis
The focus of this study is to optimize the delivery of a combined strength and aerobic training regimen to individuals with post stroke hemiparesis and reduce overuse and inefficiencies associated with the nonparetic leg during…
- Trial name
- NCT04877249
- Testing
- Split-belt treadmill training
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Stroke
Effects of Flexion and Extension Type Arm Slings on Walking Kinematics and Balance in Stroke Patients
In the clinic, stroke patients are seen to use flexor or extensor type arm slings, but no study was found investigating the effects of these different types of arm slings on walking kinematics and balance.
- Trial name
- NCT07036900
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ceren Bayrak
Acute Ischemic Stroke (AIS)
A Phase I Clinical Trial Evaluating the Safety, Tolerability and Pharmacokinetics of AAPB for Injection
This is a Phase I clinical to evaluate the safety and tolerability of single and multiple intravenous infusions of AAPB at different doses over 7 consecutive days.
- Trial name
- AAPB (NCT06679998)
- Testing
- Single dose, AAPB by injection, intravenous drip., Multiple dosing, AAPB for injection, intravenous drip
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu Kanion Pharmaceutical Co., Ltd
Stroke
BE FAST vs. FAST: A Study in the General Public.
A randomized, blinded prospective study assessing retention of two stroke mnemonics (BE FAST and FAST) in the general public after receiving brief stroke education.
- Trial name
- BFF (NCT06152016)
- Testing
- BE-FAST, FAST
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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