Clinical trials: tACS
Stroke
Modulation of Cortical Gamma Synchrony in Stroke
In the last decades, the research in neuroimaging-informed stroke prognosis and treatment has had a little clinical impact, often because of the costs of bringing complex procedures to the bedside.
- Trial name
- GAMMASTROKE (NCT05830617)
- Testing
- real tACS
- Where
- Italy
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Dysphagia, Swallowing Disorder
tACS and tRNS Studies on Brain Control of Swallowing
Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are two (CE marked medical devices) new, non-invasive (over the scalp) brain stimulation (NIBS) techniques.
- Trial name
- NCT04040803
- Testing
- Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Parkinson's Disease (PD), Tremor
Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage.
- Trial name
- tACS_PD_TR (NCT06993571)
- Testing
- Active-tACS, Unlocked-tACS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Non-suicidal Self-injury
Effects of taVNS Combined With tACS on Adolescents With Non-Suicidal Self-Injury
NSSI behavior is highly prevalent among adolescents, and its mechanisms are closely associated with attentional bias toward self-injury-related information and impulsivity, both of which may be related to reduced dlPFC activation…
- Trial name
- NCT07486804
- Testing
- 25Hz、300us transcutaneous auricular vagus nerve stimulation and10hz transcranial alternating current stimulation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University
Understand the Effects of tACS on the Brain
Investigating Transcranial Alternating Current Stimulation (tACS) Preconditioning Effects on Resting and Active Motor Threshold
Previous studies have looked at the potential of using transcranial direct current stimulation (tDCS) to prime the brain in order to lower the resting motor threshold.
- Trial name
- NCT05503823
- Testing
- tACS or tRNS and TMS
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Aphasia, Stroke
Transcranial Alternating Current Stimulation (tACS) in Aphasia
This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.
- Trial name
- NCT04375722
- Testing
- tACS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Antenatal Depression, Major Depressive Disorder
Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)
The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.
- Conditions
- Antenatal Depression, Major Depressive Disorder, Major Depressive Disorder in Pregnancy, Healthy Controls
- Trial name
- PandA-tACS (NCT06979154)
- Testing
- tACS (aperiodic)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Stimulation, Alzheimer Disease
Transcranial Alternating Current Stimulation (TACS) for Sleep Disturbances in Neurocognitive Disorders Due to Alzheimer's Disease
Background: Sleep disturbances are highly prevalent in ageing population and patients with age-related neurodegenerative diseases, which severely affect cognition and even lead to accumulated amyloid-β (Aβ).
- Conditions
- Brain Stimulation, Alzheimer Disease, tACS, Sleep Disturbance
- Trial name
- NCT05544201
- Testing
- High-definition transcranial current stimulation
- Where
- Hong Kong
- Volunteers
- 99 people
- Sponsor
- Chinese University of Hong Kong
Stuttering, Adult, Stuttering, Childhood
Transcranial Alternating Current Stimulation (tACS) in Stuttering
The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that…
- Conditions
- Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06740968
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Cognitive Dysfunction, Alzheimer Disease
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06733714
- Testing
- Transcranial Alternating Current Stimulation, Digital Cognitive Training
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Alzheimer Disease
Effect of Modulating Gamma Oscillations Using tACS
This study aims to implement an intervention based on multiple, individualized multifocal tACS stimulation sessions based on individual PET and MRI information in patients with amyloid-positive PET with the hope that this leads…
- Trial name
- NCT03412604
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Adults With Variability in Their Mood
Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)
Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day
- Trial name
- BandR (NCT07252011)
- Testing
- Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Disorders of Consciousness
Intervention Effect of Transcranial Alternating Current Stimulation (tACS) on Disorder of Consciousness (DOC)
To investigate the effect of high definition-transcranial alternating current stimulation(HD-tACS) on consciousness promotion in patients with chronic consciousness disorders and the underlying neural mechanism by EEG.
- Trial name
- NCT06076733
- Testing
- high definition-transcranial alternating current stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Generalized Anxiety Disorder (GAD), Chronic Insomnia
Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot Study
This is an open-label pilot clinical trial to evaluate the effects of transcranial alternating current stimulation (tACS) in adults diagnosed with generalized anxiety disorder (GAD) and chronic primary insomnia.
- Trial name
- NewWaves (NCT07429578)
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Neuroimmune Diseases With Insomnia
Study on the Clinical Efficacy of Transcranial Strong Alternating Current (Hi-tACS) in Patients With Neuroimmune Diseases With Insomnia
This study aims to comprehensively evaluate the therapeutic effects of high-intensity transcranial alternating current stimulation (hi-tACS) on insomnia symptoms in patients with idiopathic inflammatory demyelinating disorders…
- Trial name
- NCT07558616
- Testing
- high-intensity transcranial alternating current stimulation, hi-tACS
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Deep Brain Stimulation, Parkinson's Disease (PD)
Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop
The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and…
- Trial name
- NCT07139093
- Testing
- DBS-coupled tACS
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Schizophrenia, Schizoaffective Disorder
Theta tACS During Working Memory Training: A Pilot Study of the Effects on Negative Symptoms of Schizophrenia
In this randomized double-blind trial, we investigated whether externally induced left-hemispheric frontoparietal theta synchronization by multi-electrode online theta (6Hz) transcranial alternating current stimulation (tACS)…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Negative Symptoms, Working Memory Training
- Trial name
- NCT04545294
- Testing
- Theta tACS
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Free Gingival Graft, Soft Tissue Augmentation Around Dental Implants
Clinical Evaluation of a Modified Technique for Free Gingival Graft Stabilization Using Titanium Fixation Tacs Around Implants Versus Conventional Suturing Technique
The aim of this randomized, controlled, parallel-grouped, clinical trial is to evaluate the width of keratinized gingiva after free gingival graft stabilized by titanium fixation tacs compared to traditional suturing.
- Conditions
- Free Gingival Graft, Soft Tissue Augmentation Around Dental Implants, Inadequate Keratinized Tissue Around Dental Implants
- Trial name
- NCT07019428
- Testing
- Free gingival graft stabilized by Titanium fixation tacs, Free gingival graft stabilized by sutures
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University