Clinical trials: tuberculosis
Tuberculosis
A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis
This research is being done to determine if Nitazoxanide (NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment.
- Trial name
- NCT02684240
- Testing
- Nitazoxanide, Control
- Where
- Haiti
- Volunteers
- 30 people
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Tuberculoses
Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of RESP30TB in Tuberculosis
A Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of Nebulised RESP30TB in Adults with Newly Diagnosed, Rifampicin Susceptible Pulmonary Tuberculosis
- Trial name
- NCT07073638
- Testing
- RESP30TB, HRZE (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol combination)
- Where
- South Africa
- Volunteers
- 24 people
- Sponsor
- Thirty Respiratory Limited
Tuberculosis
To Evaluate the Safety, Tolerability, and Efficacy of TMC207 as Part of an Individualized Multi-drug Resistant Tuberculosis (MDR-TB) Treatment Regimen in Participants With Sputum Smear-positive Pulmonary MDR-TB.
The purpose of this study is to evaluate the safety, tolerability and effectiveness of TMC207 in combination with an individualized background regimen (BR) of antibacterial drugs as treatment for MDR-TB
- Trial name
- NCT00910871
- Testing
- TMC207, Background Regimen (BR) for MDR-TB
- Where
- 27 sites in China, Estonia and 10 more
- Volunteers
- 241 people
- Sponsor
- Janssen Infectious Diseases BVBA
Inflammatory Rheumatic Diseases
A Study on Changes in IFN-gamma Levels Following Anti-TNF Treatment in Patients Undergoing Serial QuantiFERON-TB Gold In-Tube
The screening for latent tuberculosis infection (LTBI) prior to the onset of anti-tumor necrosis factor therapy, as well as a watchful monitoring during the treatment, is strongly recommended.
- Trial name
- NCT01475409
- Testing
- QuantiFERON-TB Gold In-Tube (QFT-GIT)
- Volunteers
- 119 people
- Sponsor
- University of Roma La Sapienza
Tuberculosis, MDR
Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among…
- Trial name
- PHOENIx MDR-TB (NCT03568383)
- Testing
- Delamanid (DLM), Isoniazid (INH), Pyridoxine (vitamin B6)
- Where
- 31 sites in Botswana, Brazil and 11 more
- Volunteers
- 5,832 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus (HIV), Tuberculosis
Pharmacokinetics of Intracellular TFV-DP and FTC-TP in HIV-infected Adolescents
Tenofovir (TFV) disoproxil fumarate (TDF) plus emtricitabine (FTC) or lamivudine (3TC) is the preferred nucleoside backbone of first-line antiretroviral therapy (ART) for adolescents in sub-Saharan Africa.
- Conditions
- Human Immunodeficiency Virus (HIV), Tuberculosis, Coinfection
- Trial name
- NCT03800394
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 52 people
- Sponsor
- University of Florida
Tuberculosis, Pulmonary
Fibroblast Activating Protein (FAP) PET/CT in Adults With Tuberculosis
This is an early phase study in patients with Tuberculosis (TB) to evaluate Fibroblast Activating Protein (FAP) activation as a marker of fibrosis.
- Trial name
- NCT07830771
- Testing
- [18F]-FAPI-74
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Tuberculosis, HIV
Nutrition, Diabetes and Pulmonary TB/HIV
We propose a randomised trial among pulmonary TB patients, examined and treated as part of the national TB control programme (WHO, 2003). The aim is to improve TB treatment outcome in high TB and HIV burden countries.
- Conditions
- Tuberculosis, HIV, Diabetes
- Trial name
- NCT00311298
- Testing
- Multimicronutrients, Energy and proteins
- Where
- Tanzania
- Volunteers
- 1,250 people
- Sponsor
- University of Copenhagen
Tuberculosis
Phase 1 Study of PBTZ169
Open-label prospective non-comparative safety, tolerability and pharmacokinetics ascending dose randomized cohort study of PBTZ169 (capsules 40 mg) in fasted healthy volunteers after single and multiple oral administration
- Trial name
- NCT03036163
- Testing
- PBTZ169 - 40 mg, PBTZ169 - 80 mg, PBTZ169 - 160 mg
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nearmedic Plus LLC
Extrapulmonary Tuberculosis
A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis
This is a prospective, multicenter, observational study (mEX-TB study) of patients with extrapulmonary tuberculosis (EPTB). Adult patients newly diagnosed with EPTB will prospectively be enrolled into the study.
- Trial name
- mEX-TB (NCT06875336)
- Testing
- biomarker analysis
- Where
- 6 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Cologne
TB, Tuberculosis
TB Stigma in the UK: Patients Experiences and Everyday Responses
Public understanding of tuberculosis (TB) is shaped by sociocultural norms, educational background, and personal experiences. Misconceptions about TB transmission, disease severity, and treatment side effects are widespread…
- Conditions
- TB, Tuberculosis, Stigma, TB Stigma
- Trial name
- TB stigma (NCT07609264)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Bournemouth University
Mediastinal Lymphadenopathy, Tuberculous Mediastinal Lymphadenopathy
Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)
Although mediastinal tuberculous lymphadenopathy is not rare in adults of such an abnormality. Isolated mediastinal without a parenchymal lung lesion in adults is unusual with the incidence of 0.25%-5.8%.
- Trial name
- NCT01121432
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Tuberculosis Multi Drug Resistant Active
Efficacy and Tolerability of Delamanid, Linezolid, Pyrazinamide and Levofloxacin
The proposed study will randomize adults (18 years of age or older) with pulmonary MDR-TB with sputum that contains M. tuberculosis that is isoniazid and rifampin resistant by MTBDRplus and fluoroquinolone susceptible by MTBDRsl…
- Trial name
- DAZZLE (NCT02975570)
- Testing
- Delamanid, Linezolid, Levofloxacin
- Sponsor
- Boston University
Tuberculosis (TB)
Digital Psychosocial Interventions on Stigma and Health Outcomes in TB Patients
This study addresses the shortcomings of routine clinical management for tuberculosis (TB) patients by proposing psychosocial interventions targeting stigma, while investigating the current status of stigma, psychological issues…
- Trial name
- NCT07742683
- Testing
- Online Mindfulness, Online CBT Intervention, Human-computer Interaction
- Volunteers
- 496 people
- Sponsor
- Peking Union Medical College
Tuberculosis
Improve Treatment Outcomes for Tuberculosis Infection in Tertiary Care Hospitals
Early diagnosis can contribute to good treatment outcomes and isolate infection control.
- Trial name
- NCT03042754
- Testing
- XpertMTB/RIF
- Where
- 4 sites in Thailand
- Volunteers
- 150 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Tuberculosis
Tuberculosis Recurrence Upon Treatment With Highly Active Antiretroviral Therapy
This is a cohort observational study investigating the rate of tuberculosis (TB) recurrence in adult patients who have completed TB therapy for Pulmonary TB (PTB) and are on highly active antiretroviral therapy (HAART).The…
- Trial name
- TRuTH (NCT01539005)
- Where
- South Africa
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Extrapulmonary Tuberculosis, Lymph Node Tuberculosis
Positron Emission Tomography in Extrapulmonary Tuberculosis
Tuberculosis (TB) remains a major public health problem. In extra-pulmonary forms, evidence of bacteriological cure is difficult to be obtained raising the need for other therapeutic assessment tools.
- Conditions
- Extrapulmonary Tuberculosis, Lymph Node Tuberculosis, Bone Tuberculosis
- Trial name
- TUBOGTEP (NCT01613196)
- Testing
- Positron Emission Tomography with 18F-Fluoro-deoxy-glucose
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
A Retrospective Study on the Treatment Pattern and Clinical Prognosis of Severe Tuberculosis Patients
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis of severe tuberculosis patients.
- Trial name
- NCT06021041
- Where
- 2 sites in China
- Volunteers
- 900 people
- Sponsor
- Tongji Hospital
HIV, Tuberculosis
Preliminary Evaluation of a Point-Of-Care Liver Function Test
The proposed preliminary field evaluation will compare a point-of-care (POC) transaminase test with the standard of care test used in an HIV clinic at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
- Conditions
- HIV, Tuberculosis, Drug-Induced Liver Injury
- Trial name
- DFA (NCT01705041)
- Testing
- Diagnostics for All liver function test (LFT)
- Where
- Vietnam
- Volunteers
- 700 people
- Sponsor
- PATH
Tuberculous Meningitis, Tuberculous Arachnoiditis
Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes
The goal of this Diagnostic accuracy study is To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and To study the correlation of imaging findings in tubercular meningitis and…
- Trial name
- NCT05636254
- Testing
- MRI Brain and spine, Reference standard diagnostic criteria
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
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