Clinical trials: in Cambodia
Perinatal Mortality
Saving Babies Lives
The central hypothesis of this study is that a neonatal healthcare programme that has a significant impact on neonatal mortality and which spans the healthcare journey from village to referral hospital can be developed and…
- Trial name
- SBL (NCT04663620)
- Testing
- Saving Babies Lives Programme, No Saving Babies Lives Programme
- Where
- Cambodia
- Volunteers
- 24,040 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cause of Mortality, Cause of Neonatal Death
Defining Causes of Deaths in South and Southeast Asia
Brief Summary: Mortality data are important in low and middle-income countries to assess the population health status and trends.
- Conditions
- Cause of Mortality, Cause of Neonatal Death, Cause of Child Death, Cause of Maternal Death
- Trial name
- SEACTN-VA (NCT04595656)
- Testing
- verbal autopsy interview
- Where
- 5 sites in Bangladesh, Burma and 3 more
- Volunteers
- 3,413 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Anemia, Pregnancy
Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia
Malnutrition among pregnant women in low- and middle-income countries (LMICs) can cause micronutrient deficiencies that result in adverse maternal and neonatal health outcomes.
- Conditions
- Anemia, Pregnancy, Micronutrients, Supplement
- Trial name
- TIPS-Cambodia (NCT07400796)
- Testing
- Multiple micronutrient supplement (MMS) for pregnancy
- Where
- Cambodia
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypoxemia, Morality
Health Systems and Policy Contexts of Medical Oxygen
This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies.
- Conditions
- Hypoxemia, Morality, Pneumonia
- Trial name
- MOXY-HSP (NCT06169514)
- Testing
- No intervention
- Where
- 6 sites in Cambodia, Laos and 4 more
- Volunteers
- 1 people
- Sponsor
- Murdoch Childrens Research Institute
Adherence to Care
Exploring Behavioral Interventions to Improve Adherence to Multiple Micronutrient Supplements Among Pregnant Women in Cambodia
The goal of this mixed method study is to learn how three different behavioral interventions can help pregnant women in Cambodia take a daily multiple micronutrient supplement (MMS) as recommended during pregnancy and to…
- Trial name
- NCT07388433
- Testing
- Family support session, Tracking Calendar, MMS educational video package
- Where
- Cambodia
- Volunteers
- 36 people
- Sponsor
- Helen Keller International
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Tuberculosis, HIV-1-infection
Determination of Adequate Tuberculosis Regimen in Patients Hospitalized With HIV-associated Severe Immune Suppression
DATURA trial is a phase III, multicenter, two-arm, open-label, randomized superiority trial to compare the efficacy and the safety of an intensified tuberculosis (TB) regimen versus standard TB treatment in HIV-infected adults…
- Conditions
- Tuberculosis, HIV-1-infection, Immuno-Deficiency
- Trial name
- DATURA (NCT04738812)
- Testing
- Intensified TB treatment (initial phase), WHO standard TB treatment (initial phase)
- Where
- 6 sites in Cambodia, Cameroon and 4 more
- Volunteers
- 1,330 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Rehabilitation, Physical Therapy
The Combined FIFA 11+ and Change of Direction Training
The study has investigated the effects of adding change of direction (COD) training to the FIFA 11+ on lower extremity performance in soccer players.
- Trial name
- NCT06262087
- Testing
- Change of direction training, FIFA 11+ program
- Where
- Cambodia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Tuberculosis, Severe Pneumonia
Impact of Systematic Early Tuberculosis Detection Using Xpert MTB/RIF Ultra in Children With Severe Pneumonia in High Tuberculosis Burden Countries (TB-Speed Pneumonia)
Despite progress in reducing tuberculosis (TB) incidence and mortality in the past 20 years, TB is a top ten cause of death in children under 5 years worldwide.
- Conditions
- Tuberculosis, Severe Pneumonia, Covid19
- Trial name
- NCT03831906
- Testing
- Xpert MTB/RIF Ultra (Ultra)
- Where
- 16 sites in Cambodia, Cameroon and 4 more
- Volunteers
- 2,570 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
HCV Infection
Study of DAA Treatment for Children and Adolescents With Active HCV Infection in Cambodia
The goal of this clinical trial is to evaluate the effectiveness of sofosbuvir/daclatasvir combination for children aged ≥ 6 years old and adolescents with active HCV infection in Cambodia
- Trial name
- HEPEDIAC (NCT05992077)
- Testing
- Sofosbuvir/Daclatasvir
- Where
- 4 sites in Cambodia
- Volunteers
- 21,000 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hiv
HIV-1 Subtype-specific Drug Resistance in Patients Failing Dolutegravir (DTG) Based Regimen
This is a prospective observational study enrolling People Living with HIV (PLHIV) who are on a Dolutegravir-based AntiRetroviral Treatment (ART) regimen and experiencing virologic failure.
- Trial name
- DTG-Resist (NCT06285110)
- Where
- 22 sites in Argentina, Brazil and 14 more
- Volunteers
- 1,103 people
- Sponsor
- University of Bern
Chronic Kidney Disease on Hemodialysis
The Self-management Program on Hemodialysis Patients in Cambodia
Chronic kidney disease (CKD) is a growing global health issue, with increasing numbers of patients requiring kidney replacement therapy (KRT), particularly in low- and middle-income countries.
- Trial name
- NCT06871553
- Testing
- Self management education program
- Where
- Cambodia
- Volunteers
- 45 people
- Sponsor
- Hiroshima University
Hepatitis C, Testing
Community Versus Facility-based Services to Improve the Screening of Active HCV Infection in Cambodia
Objectives Principal objective: to compare the effectiveness of a community-based intervention to a facility-based intervention to improve the combined-testing uptake (Antibody + RNA) of HCV infection among general population…
- Trial name
- Cam-C (NCT03992313)
- Testing
- Community-based HCV rapid test, Facility-based HCV rapid test, Plasmatic HCV viral load
- Where
- 2 sites in Cambodia
- Volunteers
- 7,692 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Malaria
Repellents as Added Control Measure to Long Lasting Insecticidal Nets
The scaling up of Long Lasting Insecticidal Nets (LLIN) and the expansion of Indoor Residual Spraying (IRS) has contributed to a significant decrease of malaria worldwide.
- Trial name
- MalaResT (NCT01663831)
- Testing
- Mosquito topical repellent
- Where
- Cambodia
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Febrile Illness
Village Malaria Worker Expansion
This project will conduct pragmatic operational research in rural communities served by approximately 12 health centres and 120 village malaria workers in Battambang/Pailin, western Cambodia.
- Trial name
- CAM-VMW (NCT05045547)
- Where
- Cambodia
- Volunteers
- 7,191 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Post-Traumatic Stress Disorder
Trauma Informed Treatment Algorithms for Novel Outcomes
This randomized controlled trial (RCT) will examine the feasibility, acceptability, and preliminary efficacy of a beginning treatment for Post-Traumatic Stress Disorder (PTSD) with Behavioral Activation (BA).
- Trial name
- TITAN (NCT04304378)
- Testing
- Stabilization Techniques (ST), Stabilization Techniques with Behavioral Activation (ST+BA), Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- 2 sites in Cambodia
- Volunteers
- 198 people
- Sponsor
- University of Missouri, St. Louis
Hospital Infections, Environment, Controlled
CLEAN Frontline: A Stepped Wedge Cluster Trial
Environmental hygiene is a key component of infection prevention in healthcare, and a driver of healthcare associated infections.
- Conditions
- Hospital Infections, Environment, Controlled, Infection Control
- Trial name
- NCT05540886
- Testing
- TEACH CLEAN
- Where
- Cambodia
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Vivax Malaria, Plasmodium Vivax
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
Health care facility based, randomized, controlled, open label, superiority trial with 3 arms
- Conditions
- Vivax Malaria, Plasmodium Vivax, Malaria, Vivax, Malaria Relapse
- Trial name
- EFFORT (NCT04411836)
- Testing
- Tafenoquine, Primaquine
- Where
- 6 sites in Cambodia, Ethiopia and 2 more
- Volunteers
- 960 people
- Sponsor
- Menzies School of Health Research
Pregnancy Related, Antenatal Care
Multiple Micronutrient Supplementation vs Iron and Folic Acid Among Pregnant Women in Cambodia
Iron and folic acid (IFA) supplements are currently provided to Cambodian women during pregnancy. However, recent research has showed benefit of a multiple micronutrient supplement (MMS) over just IFA alone on several outcomes of…
- Conditions
- Pregnancy Related, Antenatal Care, Iron Folic Acid Supplementation
- Trial name
- MMS-Cambodia (NCT05867836)
- Testing
- IFA vs. MMS during pregnancy
- Where
- Cambodia
- Volunteers
- 1,545 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fever
Clinical Evaluation of the FilmArray® Global Fever (GF) Panel
This study will evaluate the clinical sensitivity and specificity of the FilmArray Global Fever (GF) Panel.
- Trial name
- NCT02968355
- Testing
- Observational study
- Where
- 11 sites in United States, Cambodia and 8 more
- Volunteers
- 2,084 people
- Sponsor
- BioFire Defense LLC