Clinical trials: in Croatia
Cruciate Ligament Reconstruction
Comparison of Tendon and Muscle-Tendon Semitendinosus Grafts After ACL Reconstruction
Aim: Comparison of tendon to bone ingrowth in bone tunnels and intra-articular remodeling of the graft after anterior cruciate ligament surgery with a muscle-tendon graft and those with a tendon graft.
- Trial name
- CandyStripe (NCT07404046)
- Testing
- ACL reconstruction
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Dubrava
Early Breast Cancer, Locally Advanced Breast Cancer
A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer
This is a Phase IIIb, multinational, multicenter, randomized, open-label study to evaluate patient preference of the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous use (PH FDC SC) administration in the home…
- Conditions
- Early Breast Cancer, Locally Advanced Breast Cancer, Inflammatory Breast Cancer
- Trial name
- ProHer (NCT05415215)
- Testing
- Fixed Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Use (PH FDC SC), Pertuzumab IV, Trastuzumab IV
- Where
- 45 sites in Argentina, Bosnia and Herzegovina and 15 more
- Volunteers
- 346 people
- Sponsor
- Hoffmann-La Roche
Systolic Left Ventricular Dysfunction
Performance and Safety of the Cardiac Microcurrent Therapy System
Patients with idiopathic dilative cardiomyopathy who have systolic left ventricular dysfunction (NYHA III - IV) despite adequate therapy according to treatment guidelines of heart failure and who have a baseline left ventricular…
- Trial name
- C-MIC-II (NCT04662034)
- Testing
- CMIC, Standard of Care (SOC)
- Where
- 20 sites in Bosnia and Herzegovina, Bulgaria and 9 more
- Volunteers
- 70 people
- Sponsor
- Berlin Heals GmbH
Atrial Fibrillation (AF)
Feasibility, Safety, Cost-effectiveness, and Environmental Impact of Reprocessed Ablation Catheters in PVI
This study evaluates whether re-sterilized (reprocessed) ablation catheters are as effective and safe as new ablation catheters when used for pulmonary vein isolation in patients with atrial fibrillation.
- Trial name
- RE-USE PVI (NCT07389434)
- Testing
- Participants will undergo pulmonary vein isolation using pulsed field ablation (PFA). The intervention consists of the use of either a reprocessed electroporation ablation catheter or a new electropor
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University Hospital Dubrava
Apical Periodontitis
Effectiveness of Laser-activated Photoacoustic Flow in One-visit Revision of Teeth With Apical Periodontitis
The main objective of the clinical randomized study is to examine the effectiveness laser-activated irrigation (LAI) on the removal of intracanal microorganisms and the healing of an inflammatory periapical lesion of a tooth…
- Trial name
- NCT07387809
- Testing
- Laser activated irrigation, Sound-activated irrigation
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University of Zagreb
Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation
The Role of Transcutaneous Vagus Nerve Stimulation in Treatment of Acute Brain Injury
Acute brain injury is a major global health problem associated with high mortality and morbidity, limited therapeutic options, prolonged hospital stays, and long-term disability that significantly impairs quality of life and…
- Conditions
- Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation, Neuromodulation, Immunomodulation
- Trial name
- NCT07384845
- Testing
- transcutaneous vagus nerve stimulation (tVNS)
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Chronic Obstructive Pulmonary Disease
A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
The purpose of this study is to evaluate the efficacy and the safety of two doses of CHF6001 (Tanimilast) as add-on to maintenance triple therapy in the target patient population.
- Trial name
- PILLAR (NCT04636814)
- Testing
- CHF6001 1600µg, CHF6001 3200µg, Roflumilast
- Where
- 460 sites in United States, Argentina and 26 more
- Volunteers
- 3,973 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Late-perimenopause, Menopause
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
The goal of this randomised controlled trial is to investigate whether Time-Restricted Eating (TRE) combined with a Low Glycaemic Index Mediterranean Diet can improve cognitive function, metabolic health, and biological ageing in…
- Conditions
- Late-perimenopause, Menopause, Perimenopause
- Trial name
- NutriAge (NCT07378787)
- Testing
- Time-Restricted Low-Glycaemic Index Diet
- Where
- 2 sites in Croatia, Cyprus
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Gingivitis, Malocclusion
Dental Biofilm Control During Orthodontic Treatment
Orthodontic appliances can affect changes in the relationships of members of the oral microbiome. Microbiome imbalance can result in oral infections and complicate treatment.
- Trial name
- ORTHOBIOFILM (NCT05532241)
- Testing
- fixed metal orthodontic appliance, fixed non-metal orthodontic appliance, oral hygiene
- Where
- 3 sites in Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Transcutaneous Application of Gaseous CO2
The research is designed to evaluate influence of transcutaneous application of CO2 (carbon dioxide) on chronic wound healing. Transcutaneous application of CO2 is known to have immediate effect on vasodilatation and elevates…
- Trial name
- NCT04561609
- Testing
- Transcutaneous CO2 application
- Where
- 3 sites in Croatia, Slovenia
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Pancreas Adenocarcinoma
Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)
Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line…
- Trial name
- NCT03377491
- Testing
- NovoTTF-200T, Gemcitabine, nab paclitaxel
- Where
- 199 sites in United States, Australia and 18 more
- Volunteers
- 571 people
- Sponsor
- NovoCure Ltd.
Rocuronium, Muscle Weakness
General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery
Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents.
- Conditions
- Rocuronium, Muscle Weakness, General Anaesthesia
- Trial name
- NCT04760912
- Testing
- Rocuronium, General anesthesia for surgery
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Centre Zagreb
Infections, Bacterial, Sepsis Bacterial
Therapeutic Options for CRAB
CRAB infections in ICUs are on the rise, leading to higher morbidity, mortality, and healthcare costs due to resistance to most antibiotics, including carbapenems.
- Trial name
- TheraCRAB (NCT06440304)
- Testing
- Fosfomycin, Eravacycline, ampicillin/sulbactam
- Where
- Croatia
- Volunteers
- 108 people
- Sponsor
- Clinical Hospital Centre Zagreb
Myelofibrosis (MF)
A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis
This is a Phase 2 open-label, multicenter study evaluating tolerability and efficacy of navitoclax alone or when added to ruxolitinib in participants with myelofibrosis.
- Trial name
- REFINE (NCT03222609)
- Testing
- Ruxolitinib, Navitoclax
- Where
- 91 sites in United States, Australia and 12 more
- Volunteers
- 191 people
- Sponsor
- AbbVie
Ulcerative Colitis (UC)
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
The purpose of this study is to evaluate safety and efficacy of risankizumab in participants with ulcerative colitis (UC) in participants who responded to induction treatment with risankizumab in a prior AbbVie study of…
- Trial name
- COMMAND (NCT03398135)
- Testing
- risankizumab
- Where
- 426 sites in United States, Argentina and 41 more
- Volunteers
- 1,242 people
- Sponsor
- AbbVie
Major Abdominal Surgeries, Mechanical Ventilation
Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study
This study will include patients aged 50 and older scheduled for elective abdominal oncologic surgery, classified as ASA II and III due to increased anaesthetic and surgical risk. Gender will not be a stratification factor.
- Trial name
- IMMEDIUM (NCT07339449)
- Testing
- Multimodal monitoring
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Dubrava
Asthma
Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma
This is a randomised, placebo-controlled, double-blind study to assess the efficacy and safety of Atuliflapon administered once daily over a 12-week treatment period to adult participants with moderate to severe uncontrolled…
- Trial name
- FLASH (NCT05251259)
- Testing
- Atuliflapon
- Where
- 234 sites in United States, Argentina and 18 more
- Volunteers
- 670 people
- Sponsor
- AstraZeneca
Thyroid Associated Orbitopathy
OCT Angiography Drived Alterations in Thyroid-associated Orbitopathy
The aim of this observational study is to evaluate retinal microvascular alterations in patients with thyroid-associated orbitopathy (TAO) using optical coherence tomography angiography (OCTA).
- Trial name
- TAO (NCT07341347)
- Where
- Croatia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Schizophrenia
An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants With Schizophrenia
The primary objective of the study is to evaluate the comparative bioavailability of TV-44749 administered subcutaneous (sc) to oral olanzapine (ZYPREXA®) at steady state in participants with schizophrenia.
- Trial name
- NCT06315283
- Testing
- TV-44749, Oral olanzapine
- Where
- 9 sites in United States, Croatia and 2 more
- Volunteers
- 153 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Ulcerative Colitis (UC)
A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had…
- Trial name
- U-ACTIVATE (NCT03006068)
- Testing
- Upadacitinib (ABT-494)
- Where
- 492 sites in United States, Argentina and 44 more
- Volunteers
- 950 people
- Sponsor
- AbbVie
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