Clinical trials: in Croatia
Generalized Tonic Clonic Seizures
A Safety, Efficacy and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric and Adult Subjects With Primary Generalized Tonic-Clonic (i.e., Grand Mal) Seizures.
The study is designed to evaluate the safety, tolerability and efficacy of two doses of pregabalin as add-on treatment in pediatric and adult subjects with Primary Generalized Tonic-Clonic (PGTC) seizures as compared to placebo.
- Trial name
- NCT01747915
- Testing
- Pregabalin Dose Level 1, Pregabalin Dose Level 2
- Where
- 127 sites in United States, Austria and 24 more
- Volunteers
- 219 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Gastrostomy
CO2 vs Air Insufflation in Children Undergoing PEG
Ap¬plications of CO2 insufflation for endoscopic procedures have been reported for the performance of routine colonoscopy, small bowel endoscopy, endoscopic retro¬grade cholangiopancreatography (ERCP) and endoscopic submucosal…
- Trial name
- NCT04714021
- Testing
- CO2, air
- Where
- 7 sites in Belgium, Croatia and 5 more
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Severe Haemophilia A
Assess the Efficacy and Safety of Personalized Prophylaxis Human-cl rhFVIII in Patients With Severe Haemophilia A
The rationale of this study is to further fine-tune and individualize prophylactic treatment of patients with severe Haemophilia A with the goal of keeping the trough FVIII level above 1% between doses.
- Trial name
- NCT02256917
- Testing
- Human cl rhFVIII
- Where
- 30 sites in United States, Canada and 7 more
- Volunteers
- 58 people
- Sponsor
- Octapharma
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
Neoplasms
An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib Protocol
This open-label, multicenter, non-randomized study provided continued access to vemurafenib for eligible participants with BRAF V600 mutation-positive malignancy, who were previously enrolled and treated in an antecedent…
- Trial name
- NCT01739764
- Testing
- Vemurafenib
- Where
- 83 sites in United States, Belarus and 23 more
- Volunteers
- 215 people
- Sponsor
- Hoffmann-La Roche
Temporomandibular Disorders, Orofacial Pain
Genetic Polymorphisms and Their Association With Temporomandibular Disorders
Temporomandibular disorders (TMD) are the most common orofacial pain disorders of non-dental origin with the prevalence of 6.1-10.2%, and incidence of 3.9%.
- Trial name
- GenPolTMD (NCT04694274)
- Testing
- stabilization splint, physical therapy
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Croatian Science Foundation
Relapsing-Remitting Multiple Sclerosis
BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (MS)
The primary objective of this study is to evaluate the long-term safety profile of BG00012 (dimethyl fumarate). Secondary objectives of this study are to evaluate the long-term efficacy of BG00012 using clinical endpoints and…
- Trial name
- ENDORSE (NCT00835770)
- Testing
- dimethyl fumarate
- Where
- 246 sites in United States, Australia and 32 more
- Volunteers
- 1,736 people
- Sponsor
- Biogen
Agitation Associated With, Alzheimer's Disease
A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
To compare the efficacy of 2 fixed doses of brexpiprazole with placebo in participants with agitation associated with dementia of the Alzheimer's type.
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01862640
- Testing
- Brexpiprazole, OPC-34712
- Where
- 85 sites in United States, Croatia and 5 more
- Volunteers
- 433 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Stroke, Atrial Fibrillation
GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)
In this part of the Registry Program patients with non-valvular atrial fibrillation (AF) at risk for stroke are enrolled to characterize the target population and to collect real world data on important outcome events.
- Trial name
- NCT01671007
- Where
- 522 sites in Austria, Belgium and 20 more
- Volunteers
- 10,471 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus, Type 2
Insulin Glargine U300 vs Insulin Degludec U100 in Impact on the Glycaemic and Cardiovascular Factors
To compare the impact of insulin degludec (IDeg-100) and insulin glargine U300 (IGlar-300) on cardiovascular risk parameters - glycaemic variability (GV), oxidative stress, arterial stiffness and lipid parameters - in insulin…
- Trial name
- NCT04692415
- Testing
- Degludec, Glargine U300
- Where
- Croatia
- Volunteers
- 25 people
- Sponsor
- University of Split, School of Medicine
Myelodysplastic Syndromes (MDS)
A Prospective, Multicentre European Registry for Newly Diagnosed Patients With Myelodysplastic Syndromes
Study Objectives: To collect and describe demographics, disease-management, and treatment outcomes of Myelodysplastic Syndromes (MDS) patients who are newly diagnosed and classified according to the World Health Organization…
- Trial name
- EUMDS (NCT00600860)
- Testing
- No interventions
- Where
- 18 sites in Austria, Croatia and 16 more
- Volunteers
- 4,000 people
- Sponsor
- Radboud University Medical Center
Gastric Cancer
A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer
This double-blind, placebo-controlled, randomized, multicenter, international, parallel arm study will evaluate the efficacy and safety of pertuzumab in combination with trastuzumab, fluoropyrimidine and cisplatin as first-line…
- Trial name
- JACOB (NCT01774786)
- Testing
- 5-Fluorouracil, Capecitabine, Cisplatin
- Where
- 172 sites in United States, Australia and 30 more
- Volunteers
- 780 people
- Sponsor
- Hoffmann-La Roche
Acute Pancreatitis
Balanced Crystalloid Solutions for Acute Pancreatitis
Patients diagnosed with acute pancreatitis regardless of etiology, severity of disease, and prior attacks will be randomized in two groups.
- Trial name
- NCT04688645
- Testing
- Balanced crystalloid solution, Normal saline
- Where
- Croatia
- Volunteers
- 276 people
- Sponsor
- University Hospital Rijeka
Lysosomal Acid Lipase Deficiency
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency
This Phase 3 study evaluated the efficacy and safety of 1 milligram/kilogram (mg/kg) intravenous (IV) infusions of SBC-102 (sebelipase alfa) administered every other week (qow) in participants with late onset lysosomal acid…
- Trial name
- ARISE (NCT01757184)
- Testing
- Sebelipase Alfa
- Where
- 40 sites in United States, Argentina and 13 more
- Volunteers
- 66 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
COPD, Smoking
Early Detection of COPD Patients in GOLD 0 (Smokers) Population
Even though the main risk factor for the development of chronic obstructive pulmonary disease (COPD) is smoking only in less than one third of the smokers the clinically manifest COPD will develop.
- Conditions
- COPD, Smoking, Other Diagnoses, Comorbidities, and Complications
- Trial name
- MARKO (NCT01550679)
- Where
- 6 sites in Croatia
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Covid19
Risk Stratification of Patients With Suspected COVID-19 Presenting to the ED
This project is an unfunded collaboration of approximately 30 emergency departments across Europe led by the EUSEM research network.
- Trial name
- EUROCOV (NCT04682093)
- Where
- 5 sites in Croatia, Finland and 3 more
- Volunteers
- 8,000 people
- Sponsor
- European Society for Emergency Medicine (EUSEM) Research Network
Bone Atrophy, Alveolar
Tooth Roots for Lateral Alveolar Ridge Augmentation
A deficient alveolar ridge segment in prepara¬tion for implant placement can be regenerated by several techniques. The type of graft material for each patient depends on many factors such as the anatomy, the morphology of the…
- Trial name
- NCT04678674
- Testing
- tooth root augmentation
- Where
- Croatia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Catherine Specialty Hospital
Geriatric Patients, Emergencies
European Geriatric Emergency Departments Registry Study
Geriatric presentations to emergency services comprise a significant percentage of all emergency service presentations in Europe and it has been reported that 3-23% of all emergency service presentations from various regions of…
- Conditions
- Geriatric Patients, Emergencies, Length of Stay, Early Warning Score
- Trial name
- EGERS (NCT04680299)
- Where
- 7 sites in Croatia, France and 4 more
- Volunteers
- 3,000 people
- Sponsor
- Gazi University
Adult, Myelodysplastic Syndromes
Quality of Life and Symptoms in Patients With Newly Diagnosed Myelodysplastic Syndromes
RATIONALE: Gathering information about quality of life, fatigue, and other symptoms from patients with myelodysplastic syndromes may help doctors learn more about the disease and may help plan treatment.
- Trial name
- PROMYS (NCT00809575)
- Testing
- questionnaire administration, fatigue assessment and management, observation
- Where
- 53 sites in United States, Austria and 10 more
- Volunteers
- 927 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Rationalization
The Economic Impact of Clinical Pharmacist Involvement in the Public Procurement for Medicines and in the Drug and Therapeutics Committee
The investigators have performed cost-minimisation analysis and compared the expenses based on the plan for public procurement (without clinical pharmacist involvement) for drugs with the results of public procurement based on…
- Trial name
- NCT04314336
- Testing
- Public procurement, Drug and Therapeutics Committee
- Where
- Croatia
- Volunteers
- 10,000 people
- Sponsor
- Bjelovar General Hospital
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