Clinical trials: in Eswatini
HIV Infections
Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)
The purpose of this study is long-term evaluation of long-acting injectable cabotegravir (CAB LA) for HIV pre-exposure prophylaxis (PrEP) in eligible participants who have completed DAIDS (Division of AIDS) sponsored studies HPTN…
- Trial name
- PALISADE (NCT06134362)
- Testing
- CAB LA
- Where
- 33 sites in Argentina, Botswana and 10 more
- Volunteers
- 2,998 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Neural Tube Defects, Congenital Abnormalities
Birth Outcomes In Eswatini After Transition To Dolutegravir-Based Treatment
The goal of this observational study is to assess the birth outcomes of HIV-positive women delivering in hospitals in Eswatini who are receiving dolutegravir (DTG) or other anti-retroviral (ARV) drug regimens.
- Conditions
- Neural Tube Defects, Congenital Abnormalities, Teratogens
- Trial name
- NCT05883761
- Where
- 5 sites in Eswatini
- Volunteers
- 50,075 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV/AIDS
Characteristics and Outcomes of Patients Who Received Etravirine and/or Darunavir
The objectives of this data collection activity are to: 1. Describe the baseline demographics, clinical and laboratory profile of patients who ever received darunavir (DRV) and/or etravirine (ETR), at the time of initiation on…
- Trial name
- NewHorizon (NCT04194021)
- Where
- 5 sites in Cameroon, Eswatini and 3 more
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Tuberculosis, Diagnoses Disease
Evaluating a New Stool Based qPCR for Diagnosis of Tuberculosis in Children and People Living With HIV
Stool4TB aims to evaluate an innovative stool-based qPCR diagnostic platform (with the capacity to become a POC diagnostic tool) in the high TB and HIV burden settings of Mozambique, Eswatini and Uganda, under the hypothesis that…
- Trial name
- Stool4TB (NCT05047315)
- Where
- 3 sites in Eswatini, Mozambique and 1 more
- Volunteers
- 1,967 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Pregnancy, HIV Infections
Phase 2b, Open Label, Multisite, Randomized Crossover Study of DPP Versus 2PR
To evaluate adherence to a single dual-prevention pill (DPP) compared with a two-pill regimen (2PR) for pre-exposure prophylaxis (PrEP) and pregnancy prevention in women without HIV.
- Trial name
- NCT07288190
- Testing
- DPP, 2PR, Free Choice
- Where
- 3 sites in Eswatini, Uganda and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
HIV Infections
Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women
This study will evaluate the safety and efficacy of the long-acting injectable agent cabotegravir (CAB LA) compared to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for pre-exposure prophylaxis (PrEP) in…
- Trial name
- NCT03164564
- Testing
- Oral CAB, Oral TDF/FTC, CAB LA
- Where
- 20 sites in Botswana, Eswatini and 5 more
- Volunteers
- 3,224 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV (Human Immunodeficiency Virus)
The Eswatini Study on Neurocognitive Performance in Adolescents Living With HIV
This study explores the link between inflammatory biomarkers and neurocognitive performance in adolescents living with HIV (ALHIV) in Eswatini.
- Trial name
- NCT07165639
- Where
- Eswatini
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eswatini Nazarene Health Institutions
HIV Prevention
Eswatini Ring Study: Increasing PrEP Options for Women
The study will deliver PrEP choice between oral PrEP and the PrEP ring for women in PEPFAR/USAID public health service delivery sites, building on the existing PrEP service delivery models at each site and in accordance with…
- Trial name
- NCT05889533
- Where
- 8 sites in Eswatini
- Volunteers
- 904 people, healthy volunteers welcome
- Sponsor
- FHI 360
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
COVID-19, Pneumonia, Viral
Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death
Since late December 2019, the novel human coronavirus (SARS-CoV-2) first reported in China, has spread worldwide. Vaccines to prevent SARS-CoV-2 infections have been developed in record time and several candidate vaccines have…
- Trial name
- NCT04914832
- Testing
- AZD1222
- Where
- Eswatini
- Volunteers
- 75,012 people, healthy volunteers welcome
- Sponsor
- Shabir Madhi
HIV/AIDS
Swaziland HIV Incidence Measurement Survey 2
The second Swaziland HIV Incidence Measurement Survey (SHIMS 2, 2016), is a population based HIV Impact Assessment (PHIA) that will assess the prevalence of key human immunodeficiency virus (HIV)-related health indicators.
- Trial name
- SHIMS2 (NCT04117984)
- Where
- Eswatini
- Volunteers
- 15,429 people, healthy volunteers welcome
- Sponsor
- Columbia University
Malaria
Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland
This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on…
- Trial name
- fMDA (NCT02315690)
- Testing
- dihydroartemisinin-piperaquine (DHAp), reactive case detection
- Where
- Eswatini
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV
Advancing Community Level Action for Improving MCH/PMTCT
The goal of the ACCLAIM (Advancing Community-Level Action for Improving MCH/PMTCT) project is to increase community demand for, uptake of, and retention in Maternal and Child Health (MCH) and/Prevention of Mother-to-child…
- Trial name
- ACCLAIM (NCT01971710)
- Testing
- Community leader engagement, Community days, Community Peer Groups
- Where
- 3 sites in Eswatini, Uganda and 1 more
- Volunteers
- 187,335 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV, Contraception
The Evidence for Contraceptive Options and HIV Outcomes Trial
The ECHO Study is an open-label randomized clinical trial that will compare three highly effective, reversible methods of contraception (including a non-hormonal method) to evaluate whether there is a link between use of any of…
- Trial name
- ECHO (NCT02550067)
- Testing
- DMPA, LNG, Copper IUD
- Where
- 12 sites in Eswatini, Kenya and 2 more
- Volunteers
- 7,830 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Negative People Identified at Substantial Risk for HIV Infection
PrEP Demonstration Study in Swaziland
This stepped-wedge cluster-randomized trial is embedded in an 18-month observational cohort study that has the aim to assess the operationalization of oral Pre-Exposure Prophylaxis (PrEP) in Swaziland as an additional HIV…
- Trial name
- NCT03254550
- Testing
- PrEP Promotion Package
- Where
- 6 sites in Eswatini
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
HIV/AIDS
MaxART: Early Access to ART for All in Swaziland
The purpose of this study is to evaluate the feasibility, acceptability, clinical outcomes, affordability, and scalability of offering early antiretroviral treatment to all HIV-positive individuals in Swaziland's…
- Trial name
- MaxART (NCT02909218)
- Testing
- Early Access to ART for All
- Where
- Eswatini
- Volunteers
- 3,485 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Social Stigma
Reducing Lesbian, Gay , Bisexual and Transgender (LGBT) Stigma in Swaziland and Lesotho
The specific objectives of this study are reduce stigma towards lesbian, gay, bisexual, and transgender persons in Swaziland and Lesotho, using performance ethnography at community roundtables.
- Trial name
- NCT02410434
- Testing
- LGBT Stigma Reduction Intervention
- Where
- 2 sites in Eswatini, Lesotho
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Toronto