Clinical trials: in Finland
Breast Cancer Survivor, Obesity, Overweight
tDCS Intervention in Breast Cancer Survivors With and Without Obesity Reporting Cognitive Impairment
The goal of this intervention is to investigate whether transcranial Direct Current Stimulation (tDCS) can alleviate Cancer-Related Cognitive Impairment (CRCI) in breast cancer survivors, as measured by changes in brain…
- Trial name
- LUMINA-brain (NCT07112521)
- Testing
- active tDCS
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- University of Helsinki
Graft-versus-host Disease (GVHD)
GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease
The purpose of this study is to evaluate itacitinib or placebo in combination with corticosteroids as first-line treatment of participants with Grade II to IV acute graft-versus-host disease (aGVHD).
- Trial name
- NCT03139604
- Testing
- Itacitinib, Prednisone, Methylprednisolone
- Where
- 129 sites in United States, Australia and 17 more
- Volunteers
- 439 people
- Sponsor
- Incyte Corporation
Cancer
Electronic Symptom Follow-up of Cancer Patients
Use of ePROs in oncological care have resulted in improvement of QoL, decreased ER visits, and improvement of overall survival. Furthermore, ePRO follow-up resulted in better QoL, improved ECOG status and more active cancer…
- Trial name
- NCT04081558
- Testing
- Electronic patient reported outcomes tool
- Where
- 2 sites in Finland
- Volunteers
- 43 people
- Sponsor
- Oulu University Hospital
Heart Rate Variability, Biomarker of Stress, Stress and Anxiety
Virtual vs. Traditional CPR Training: Effects on Stress
This medical education study investigates stress levels among undergraduate medical students during basic life support (BLS) training.
- Trial name
- NCT07147322
- Testing
- Medical education, basic life support training
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Cancer
Follow-up of Cancer Patients Receiving Immune Checkpoint Inhibitor Therapy by Electronic Patient Reported Outcomes-tool
Electronic patient reported outcome (ePRO) tools have improved survival and quality of life (QoL) of cancer patients receiving chemotherapy, and in the follow-up of lung cancer patients.
- Trial name
- NCT03928938
- Testing
- Electronic patient reported outcomes
- Where
- 2 sites in Finland
- Volunteers
- 43 people
- Sponsor
- Oulu University Hospital
Bleeding on Probing, Pocket Depth
This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.
A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.
- Conditions
- Bleeding on Probing, Pocket Depth, Plaque Control, Saliva Microbiome
- Trial name
- FLJS_TRE (NCT07143344)
- Testing
- Fermented lingonberry juice sprey
- Where
- Finland
- Volunteers
- 11 people
- Sponsor
- Lahanna oy
Heart Failure
Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%
The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood…
- Trial name
- FINEARTS-HF (NCT04435626)
- Testing
- Finerenone (BAY94-8862)
- Where
- 661 sites in United States, Argentina and 35 more
- Volunteers
- 6,016 people
- Sponsor
- Bayer
Atrial Fibrillation
Artificial Intelligence Models to Predict Clinically Relevant Cardiovascular Outcomes
Atrial fibrillation (AF) is a frequent and clinically relevant problem among the events that may occur during the hospitalization period in patients with cardiovascular disease.
- Trial name
- PERCARD (NCT06847100)
- Testing
- Blood withdrawal
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 273 people
- Sponsor
- Centro Cardiologico Monzino
Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) Relapse
Association of Ex Vivo Drug Response ( EVDR) and Clinical Outcome in Acute Myeloid Leukaemia (EXCYTE-2)
This is a multicentre study on biobanked bone marrow and blood samples of AML patients, conducted by Exscientia GmbH. The study aims to compare the drug response measured 'ex vivo', this means outside of the body, in the samples…
- Trial name
- EXCYTE-2 (NCT06648512)
- Testing
- No Interventions
- Where
- 3 sites in Austria, Finland and 1 more
- Volunteers
- 91 people
- Sponsor
- Exscientia AI Limited
Cancer
Assessment of Chemotherapy-induced Peripheral Neurotoxicity Using a Point-of-care Nerve Conduction Study Device
The purpose of this study is to evaluate the feasibility of the Mediracer® NCS device in early detection of CIPN in patients receiving potentially neurotoxic substance (vincristine, oxaliplatin or docetaxel) as a part of their…
- Trial name
- APPS (NCT04778878)
- Testing
- Mediracer® NCS
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- Oulu University Hospital
Osteoarthritis, Hip, Rheumatoid Arthritis
Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.
- Trial name
- OASEQ (NCT05278520)
- Testing
- Total hip arthroplasty
- Where
- 4 sites in Finland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Turku
Lung Cancer Screening
LDCT-SC-FI Low-dose CT Screening for Lung Cancer
This is a randomized phase II trial investigating different smoking cessation methods in study subjects undergoing lung cancer screening with low-dose CT (LDCT).
- Trial name
- NCT05630950
- Testing
- Smoking cessation mobile application, Written material for smoking cessation
- Where
- 2 sites in Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Chronic Subdural Hematoma, Atrial Fibrillation (AF)
Restarting Early Versus Later Anticoagulation for Chronic Subdural Hematoma With Atrial Fibrillation
The goal of this randomized clinical trial is to assess the benefit of early resumption versus late resumption of oral anticoagulation medication in adults with atrial fibrillation undergoing surgery for chronic subdural…
- Trial name
- RELACS (NCT06696079)
- Testing
- Early Resumption of Oral Anticoagulation Therapy, Late Resumption of Oral Anticoagulation Therapy
- Where
- 6 sites in Finland, Sweden
- Volunteers
- 332 people
- Sponsor
- Rahul Raj
Primary Care Provider
Ostrobothnia Digital Clinic Experiment
This randomized controlled trial (RCT) examines the impacts of a publicly provided digital clinic that offers digital primary care services to consumers.
- Trial name
- NCT06904469
- Testing
- Access to a digital clinic
- Where
- Finland
- Volunteers
- 170,306 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Influenza
Immune Responses in Health Care Personnel
This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influenza, including effects of…
- Trial name
- NCT03323112
- Testing
- influenza vaccine
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Influenza, Human
Herd Immunity and Influenza Vaccine Uptake
The aim of this study is to test the effectiveness of communicating the concept of herd immunity on actual influenza vaccine uptake using a randomized controlled trial.
- Trial name
- HIIVU (NCT03748160)
- Testing
- Letter
- Where
- Finland
- Volunteers
- 48,125 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Polycystic Ovary Syndrome (PCOS), Obesity &Amp;Amp; Overweight
Strengthening Healthy Emotional Co-regulation of Mothers With PCOS and Obesity and Their Infants
It is both timely and important to invest in interventions that can improve healthy emotional co-regulation. It is proposed to evaluate the feasibility and limited efficacy of an adapted, brief, multimodal intervention: ECoFam…
- Trial name
- ECoFam (NCT07129434)
- Testing
- ECoFam
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Oulu University Hospital
Microbial Colonization
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system.
- Trial name
- NCT03273296
- Testing
- Amoxicillin, Azithromycin, Vancomycin
- Where
- Finland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Acute Myeloid Leukemia
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
The standard treatment for patients with acute myeloid leukemia (AML) with an abnormality in the IDH1 gene, who are not eligible for intensive chemotherapy, is a combination of ivosidenib and azacitidine.
- Trial name
- EVOLVE 1 (NCT07075016)
- Testing
- Venetoclax 400
- Where
- 119 sites in Austria, Belgium and 14 more
- Volunteers
- 227 people
- Sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
Depressive Symptoms Mild to Moderate in Severity, Major Depressive Disorder
Adolescent Interpersonal Counseling in Primary Care
The demand for prevention and treatment of adolescent depression has rapidly increased over years. A national project to improve treatment of adolescent depression in primary care has taken place in Finland starting 2020.
- Trial name
- NCT06390462
- Testing
- Interpersonal counseling, Treatment as usual, No support, intervention or other treatment
- Where
- 4 sites in Finland
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare