Clinical trials: suspended, in France
Progressive Multiple Sclerosis
Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis
To evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients with primary progressive or secondary progressive multiple sclerosis without relapse.
- Trial name
- MAXIMS (NCT05441488)
- Testing
- Masitinib (4.5)
- Where
- 37 sites in France, Greece and 6 more
- Volunteers
- 800 people
- Sponsor
- AB Science
Retinitis Pigmentosa Associated With CNGB1 Mutations
CNGB1 and Allied Disorders
Mutations in the rod-expressed gene, cyclic nucleotide-gated channel beta subunit (CNGB1) and associated inborn errors in metabolism are causes of retinal disease that causes progressive loss of vision.
- Trial name
- NCT04639635
- Testing
- No intervention, this is a natural history progression study
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 20 people
- Sponsor
- Columbia University
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS).
- Trial name
- NCT04278768
- Testing
- Emavusertib, Venetoclax
- Where
- 32 sites in United States, Czechia and 6 more
- Volunteers
- 366 people
- Sponsor
- Curis, Inc.
Peritoneal Mesothelioma, Peritoneal Carcinomatosis
Treatment of Malignant Peritoneal Mesothelioma (MESOTIP)
MESOTIP is a randomized trial evaluating the association of PIPAC and systemic chemotherapy versus systemic chemotherapy alone as 1st-line treatment of Malignant Peritoneal Mesothelioma In this study, patients in the experimental…
- Trial name
- MESOTIP (NCT03875144)
- Testing
- PIPAC, Cisplatin, Pemetrexed
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Gout, Chronic Kidney Disease
Anakinra vs Prednisone to Treat Gout Flare in Patients With Chronic Kidney Disease Stage 4/5 or Renal Transplantation
Gout is secondary to urate crystal deposition after chronic elevation of serum urate level. Urate crystal deposition is responsible for acute and recurrent inflammatory flares which can be treated with colchicine, non-steroid…
- Conditions
- Gout, Chronic Kidney Disease, Renal Transplantation
- Trial name
- Ana4CKD (NCT04844814)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe, Prednisone
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ALS - Amyotrophic Lateral Sclerosis
Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis
Using a MRI gait motor imagery paradigm in ALS patients in order to study how ALS affects the function of the central neural networks involved in gait function, we showed a reorganization of the motor networks that represents a…
- Trial name
- EXALS (NCT06199284)
- Testing
- Atalante exoskeleton
- Where
- 3 sites in France
- Volunteers
- 20 people
- Sponsor
- Institut de Recherche sur la Moelle épinière et l'Encéphale
Head and Neck Cancer, Pregnancy Related
Study on the Occurrence of Head and Neck Cancers During Pregnancy
Head and neck cancers that occurred during pregnancy
- Trial name
- REFCORbirth (NCT03738267)
- Where
- 8 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Francois Baclesse
Locally Advanced Rectal Carcinoma
Endorectal Brachytherapy for Rectal Cancer
The management of rectal cancers has changed over the past decades towards a multidisciplinary strategy, combining radiotherapy, chemotherapy, and surgery.
- Trial name
- ICUREC (NCT05591534)
- Testing
- Endorectal brachytherapy
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Aneurysm
Cryoablation of Intercostal Nerves for Better Control of Postoperative Pain After Thoracic and Thoracoabdominal Open Surgery
The purpose of the registry is to evaluate the peri-operative and short- term outcomes of intercostal nerves cryoablation for post-operative pain control after open thoracic and thoracoabdominal aortic aneurysms repair.
- Trial name
- NCT05153083
- Testing
- Open thoracic (TAA) and thoracoabdominal aortic aneurysms repair (TAAA)
- Where
- 13 sites in Austria, France and 6 more
- Volunteers
- 200 people
- Sponsor
- Germano Melissano
Major Depressive Disorder
Prediction of the Response to a Course of Transcranial Magnetic Stimulation (rTMS) Based on Heart Rate Variability
Changes in heart rate variability following a single session of rTMS will be tested as a predictor of response to a course of 30 rTMS sessions in patients with major depressive disorder (MDD).
- Trial name
- DEP&MOD (NCT06451809)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- 9 sites in France
- Volunteers
- 160 people
- Sponsor
- GCS CIPS
Major Depressive Disorder
Evaluation of Response to a Course of Repetitive Transcranial Magnetic Stimulation Using Vocal Biomarkers
Voice recordings taken prior to the start of repetitive transcranial magnetic stimulation (rTMS) therapy will be used to develop a predictive model of treatment response using machine learning for patients with major depressive…
- Trial name
- SPEECHTMS (NCT06451835)
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- 9 sites in France
- Volunteers
- 156 people
- Sponsor
- GCS CIPS
Hepatocellular Carcinoma
Nivolumab in Combination With TACE/TAE for Patients With Intermediate Stage HCC
This study evaluates the addition of nivolumab to TACE/TAE in the treatment of patients with intermediate stage hepatocellular carcinoma. All patients will receive TACE/TAE and half will receive nivolumab.
- Trial name
- TACE-3 (NCT04268888)
- Testing
- Nivolumab and TACE/TAE, TACE/TAE
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 522 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Cardiac Resynchronization Therapy
cArdiac Non Invasive MApping in resynchronizaTION
Non-invasive mapping using the Cardio Insight system is performed in heart failure patients requiring biventricular pacing to optimize therapy, and understand mechanisms underlying pacing-induced cardiomyopathy and ventricular…
- Trial name
- ANIMATION (NCT04347109)
- Testing
- Non invasive epicardial mapping
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Cardiac Arrest
Early DiaGnosis of Anoxic Brain Injury for Resuscitated Patients
Sudden cardiac arrest (CA) in adults remains a major public health issue in industrialized countries, leading to a mortality rate greater than 90%.
- Trial name
- EDGAR (NCT03806660)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Septic Shock
Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients
The benefit of low-dose steroids in septic shock is still debated today, especially with mineralocorticoids. Fludrocortisone is a synthetic mineralocorticoid, an analogue of aldosterone, which has shown, in combination with…
- Trial name
- FLUDROSEPSIS (NCT05001854)
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
COPD, Chronic Respiratory Insufficiency
Oxygen Titration Protocol for Exertion of COPD Patients by an Automated Adjustment Device
The aim of our study is to assess if an automated titration of oxygen flow during exertion can be a useful tool to determinate the level of oxygen required by COPD patients that are using oxygen therapy during exercise.
- Trial name
- NCT04189991
- Testing
- Free 02
- Where
- France
- Volunteers
- 25 people
- Sponsor
- ADIR Association
Aortic Valve Regurgitation Acquired
Aortic Valve Regurgitation Acquired After Left Ventricular Assist Device Implantation: an Outstanding in Vivo Model of Valvular Heart Diseases
To investigate histological structure and molecular changes involved on the onset of AVD after left ventricular assist device (LVAD) implantation and to compare them with those of patients operated on for severe aortic…
- Trial name
- NCT03279029
- Testing
- blood samples, biopsy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Covid19, Azithromycin
Proactive Care of Ambulatory COVID19 Patients
On January 9, 2020, a new emerging virus was identified by WHO as being responsible for grouped cases of pneumonia in China. It is a coronavirus, SARS-CoV-2, responsible for the disease COVID-19 (Coronavirus disease).
- Conditions
- Covid19, Azithromycin, Ambulatory
- Trial name
- AMBU-COVID (NCT04371107)
- Testing
- consultation, Azithromycin
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Brain Lesion of the Right Hemisphere, Unilateral Spatial Neglect for Half of Them
Boosting Reward-based Attention Through VEstibular STimulation
The exploration of space is more effective when intrinsically rewarding elements are located in the visual scene. Thus, rewards could be exploited as a novel rehabilitation approach to various attentional disorders.
- Trial name
- BRAVEST (NCT03213119)
- Testing
- Non-invasive brain stimulation of the vestibular system through caloric vestibular stimulation.
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Oesophageal Adenocarcinoma, Gastric Adenocarcinoma
Combination of Capmatinib + Spartalizumab in Advanced Oesogastric Adenocarcinoma
Immunotherapy with anti-PD1 antibodies provides encouraging results on a subset of patients. Capmatinib, a MET inhibitor, has shown an imunomodulatory effect and a synergy with spartalizumab a PD-1 inhibitor.
- Trial name
- METIMGAST (NCT05135845)
- Testing
- Capmatinib, Spartalizumab
- Where
- 7 sites in France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris