Clinical trials: suspended, in Italy
HIV/AIDS
Observational Study for the Evaluation of the Role of HIV-1 Tat Protein and Anti-Tat Immune Response In HIV Reservoir
A longitudinal observational study in HIV-infected subjects receiving cART addressed to explore the effect of the Tat protein and anti-Tat immunity on the formation and maintenance of HIV-1 virus reservoir.
- Trial name
- ISS OBS T-005 (NCT04263207)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Barbara Ensoli, MD, PhD
Occlusive Arterial Disease
Aorto-iliac Occlusion Treatment With ShorT Unibody aorTic Endograft - ASTUTE Study
The goal of this multi center prospective observational study is to evaluate the iliac patency rate during the time in patients treated with "AFX (Endologix, Irvine Calif)" unibody stent-graft for aorto-iliac occlusive disease…
- Trial name
- ASTUTE (NCT05614856)
- Testing
- EVAR off-label use
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Respiratory Failure, Diaphragm Injury
Diaphragm Ultrasound as a Powerful Tool in Managing Acute Hypoxemic Respiratory Failure in Hematological Patients
Acute hypoxemic respiratory failure due to parenchymal disfunction is one of the main complications of immunocompromised hematological patients.
- Conditions
- Respiratory Failure, Diaphragm Injury, Ultrasound, Mechanical Ventilation Complication
- Trial name
- NCT04026217
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Neck Pain
Effects of Multimodal Exercises Integrated With Cognitive-behavioral Therapy in Subjects With Chronic Neck Pain
The etiology of cervical pain is multifactorial and studies based on the bio-psychosocial model also link chronic neck pain to psychological factors. Among them, kinesiophobia has been reported as an important determinant.
- Trial name
- NCT04768790
- Testing
- multidisciplinary program, General program
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- University of Cagliari
Hemorrhagic Stroke
Effectiveness of Core Stability Training on Trunk Control in Patients With Post-hemorrhagic Stroke
Stroke is responsible for about 7% of disabilities in the European population. Intracerebral hemorrhage (ICH) represents 15% of stroke cases in Europe.
- Trial name
- NCT05207345
- Testing
- Interventional programme, General exercise programme
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of Cagliari
Fetal Hypoxia, Fetal Conditions
The Relationship Between Umbilical Cord ph and Feto-maternal Doppler Studies in Scheduled Nonlaboring Term Singleton Caesarean Deliveries
Perinatal asphyxia is a crucial reason for neonatal and childhood morbidity and death. Fetal and neonatal acidemia can be utilised as predictors for establishing such risk.
- Trial name
- NCT04364308
- Testing
- Fetal Echography
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Osteosarcoma in Children
Qarziba for Patients in Relapsed/Refractory High-grade Osteosarcoma
Limited progress has been made in identifying novel targets that may be therapeutic for Osteosarcoma(OS) and there remains an urgent need for the development of new agents that are effective in improving survival.
- Trial name
- NCT05558280
- Testing
- Dinutuximab beta
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Prof. Franca Fagioli
Head and Neck Cancer
Health and Economic Outcomes of Two Different Follow up Strategies in Effectively Cured Advanced Head and Neck Cancer
Randomized, multicenter trial to evaluate the cost-effectiveness of 2 different follows up programs in head and neck cancer survivors.
- Trial name
- HETeCo (NCT02262221)
- Testing
- Scheduled radiologic evaluations
- Where
- 15 sites in Italy, Switzerland
- Volunteers
- 330 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Hip Arthrosis
Capsulectomy vs Capsulotomy in Total Hip Arthroplasty. Clinical Outcomes and Proprioception Evaluation
The purpose of our study is to evaluate the differences in functional activities and proprioception after surgery in subjects who underwent hip prosthesis implant with capsulotomy or capsulectomy.
- Trial name
- NCT02749058
- Testing
- Capsulectomy in Direct Anterior Total Hip Arthroplasty, Capsulotomy in Direct Anterior Total Hip Arthroplasty
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease
The Rolex Registry (Revascularization Of LEft Main With Resolute onyX)
The primary objective of this study is to assess the safety and efficacy of the new-generation zotarolimus-eluting stent Resolute Onyx in the treatment of unprotected left main coronary artery disease (ULMCAD), both isolated or…
- Trial name
- Rolex (NCT03316833)
- Testing
- Resolute Onyx
- Where
- 33 sites in Italy, Portugal
- Volunteers
- 450 people
- Sponsor
- University of Padova
Advanced Solid Tumor, Gynecologic Cancer
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of…
- Trial name
- NCT04042116
- Testing
- Lucitanib, Nivolumab
- Where
- 27 sites in United States, Austria and 4 more
- Volunteers
- 227 people
- Sponsor
- Clovis Oncology, Inc.
GBS Rectovaginal Colonization, Neonatal Sepsis
Probiotics and GBS Colonization in Pregnancy
Multicentric, randomized, placebo-controlled, double-blind, parallel group study aimed at evaluating the feasibility and effect of the use of probiotic starting from the 30th week, on vaginal / rectal colonization of GBS in women…
- Trial name
- NCT05156333
- Testing
- Respecta
- Where
- 3 sites in Italy
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Dyspnea
Non-pharmacological Treatment of Dyspnea in Chronic Obstructive Pulmonary Disease (COPD)
Dyspnoea is one of the most important determinants of quality of life and often limits the activities of daily life, in subjects suffering from moderate-to-severe chronic obstructive pulmonary disease (COPD).
- Trial name
- COPD (NCT04231058)
- Testing
- TENS and pulmonary rehabilitation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda USL Toscana Nord Ovest
Acute Respiratory Distress Syndrome
Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.
During moderate to severe ARDS, sessions of prone positioning lead to lung and chest wall mechanics changes that modify regional ventilation, with a final redistribution of tidal volume and PEEP towards dependent lung regions…
- Trial name
- ALTERPRONE (NCT03719937)
- Testing
- weight on the anterior chest of the patient
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
Cesarean Section Complications, Cesarean Section; Complications, Wound, Infection (Following Delivery)
The S-CARE Trial: Manual Treatment for C-sections Scars, a Pilot Study.
This study aims to examine the effects of an osteopathic treatment on adhesions related to c-sections scars.
- Trial name
- S-CARE (NCT04125498)
- Testing
- Osteopathic treatment, Self-massage
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Studio Osteopatico Busto Arsizio
Abdominal Aortic Aneurysms
AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfix™ Stent Graft
The ARCHYTAS Registry is a long-term, global, multicenter, non-randomized, prospective, registry designed to collect "on-label" data in real world clinical settings on patients undergoing endovascular repair with the latest…
- Trial name
- ARCHYTAS (NCT02480595)
- Testing
- Stent Graft
- Where
- 37 sites in Czechia, Germany and 4 more
- Volunteers
- 500 people
- Sponsor
- Lombard Medical
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Infiltration of Medical Ozone for the Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZOPROMAF (NCT05036837)
- Testing
- OZOPROMAF_SEQ1
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Diet Modification
Metabotypes in the Urinary Excretion of Flavan-3-ol Metabolites: "Metanols"
Flavan-3-ols are the main source of flavonoids in Western diets. They are characteristic compounds of tea, cocoa, wine, apple, pears, etc.
- Trial name
- Metanols (NCT04124016)
- Testing
- Inulin, green tea extract, grape seed
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Parma
Aortic Valve Stenosis
Impact of SAVR and TAVR on Patient's Activity and Mobility
This is an independent, investigator-initiated, prospective multicenter observational study with restricted grant provided by Edwards Lifesciences that aims to describe baseline (preoperative) physical function and to assess and…
- Trial name
- CAPABILITY (NCT03843320)
- Testing
- SAPIEN 3, SAPIEN XT, INSPIRIS RESILIA
- Where
- 2 sites in Italy
- Volunteers
- 340 people
- Sponsor
- University of Padova
Type 2 Diabetes, Psychological Distress
Psychological Distress and Type 2 Diabetes
Increasing evidence suggests that psychological disorders play an important role in the development and worsening of type 2 diabetes (T2D).
- Trial name
- COPEST (NCT01870141)
- Testing
- Cognitive-Behavioral Intervention
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona