Clinical trials: in Jordan
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Neuro: Cerebrovascular Accident
TECAR and FES for Hand Function in Post-Stroke Spasticity
Upper-limb spasticity and impaired hand function are experienced by up to 70% of stroke survivors, which significantly restricts their independence in fulfilling daily activities.
- Trial name
- NCT07889921
- Testing
- FES therapy, TECAR therapy and FES
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- October 6 University
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Duchenne Muscular Dystrophy
Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)
This is a Phase 1b/2 open-label study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical effects of intravenous (IV) WVE-N531 in patients with Duchenne muscular dystrophy (DMD).
- Trial name
- NCT04906460
- Testing
- WVE-N531
- Where
- 6 sites in United States, Jordan and 1 more
- Volunteers
- 25 people
- Sponsor
- Wave Life Sciences USA, Inc.
Ulcerative Colitis, Inflammatory Bowel Diseases
Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD
This is a multicenter, long-term extension (LTE) study in participants with ulcerative colitis (UC) from Study SPY123-201 (The SKYLINE-UC study).
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Colitis, Colitis, Ulcerative
- Trial name
- SKYLINE-LTE (NCT07652294)
- Testing
- SPY001, SPY002, SPY003
- Where
- 86 sites in United States, Argentina and 20 more
- Volunteers
- 645 people
- Sponsor
- Spyre Therapeutics, Inc.
Primary Immune Thrombocytopenia
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
The main aim of the study is to evaluate the safety and efficacy of efgartigimod PH20 SC (subcutaneous) in adult patients with primary immune thrombocytopenia (ITP).
- Trial name
- ADVANCE SC+ (NCT04812925)
- Testing
- efgartigimod PH20 SC
- Where
- 83 sites in United States, Argentina and 23 more
- Volunteers
- 173 people
- Sponsor
- argenx
Gingivitis, Healthy Adult
Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste
The goal of this clinical trial is to learn if Nanibiofusion Gingival Gel (NBF) is able to reduce dental plaque and gum inflammation in adults.
- Trial name
- NCT07850232
- Testing
- Nano Bio-Fusion (NBF) Gingival Gel, Commercial fluoride toothpaste
- Where
- Jordan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in participants with pediatric…
- Conditions
- Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma
- Trial name
- NCT05566795
- Testing
- Tovorafenib, Chemotherapeutic Agent
- Where
- 138 sites in United States, Australia and 28 more
- Volunteers
- 418 people
- Sponsor
- Day One Biopharmaceuticals, Inc.
Metastatic Breast Cancer
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use) compared with placebo in combination with Phesgo, as maintenance…
- Trial name
- INAVO122 (NCT05894239)
- Testing
- Inavolisib, Phesgo, Taxane-based Chemotherapy
- Where
- 192 sites in United States, Argentina and 27 more
- Volunteers
- 230 people
- Sponsor
- Hoffmann-La Roche
Sickle Cell Disease (SCD)
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.0 mg/kg and 7.5 mg/kg) versus placebo in adolescent and adult sickle cell disease (SCD) patients with history of vaso-occlusive crisis…
- Trial name
- STAND (NCT03814746)
- Testing
- Crizanlizumab (SEG101)
- Where
- 58 sites in United States, Belgium and 19 more
- Volunteers
- 253 people
- Sponsor
- Novartis Pharmaceuticals
Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
This study is open to adults who are at least 18 years old living with obesity and have: a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and moderate or advanced…
- Trial name
- NCT06632444
- Testing
- Survodutide
- Where
- 531 sites in United States, Argentina and 34 more
- Volunteers
- 1,800 people
- Sponsor
- Boehringer Ingelheim
Metabolic Dysfunction Associated Steatohepatitis
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
This study is open to adults who are at least 18 years old and have: A confirmed liver disease called non-alcoholic steatohepatitis (NASH) or A confirmed liver disease called metabolic-associated steatohepatitis (MASH) BMI of 27…
- Trial name
- NCT06632457
- Testing
- Survodutide
- Where
- 446 sites in United States, Argentina and 34 more
- Volunteers
- 1,590 people
- Sponsor
- Boehringer Ingelheim
Gaucher Disease, Cerebroside Lipidosis Syndrome
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
The ICGG Gaucher Registry is an ongoing, international multi-center, strictly observational program that tracks the routine clinical outcomes for patients with Gaucher disease, irrespective of treatment status.
- Conditions
- Gaucher Disease, Cerebroside Lipidosis Syndrome, Glucocerebrosidase Deficiency Disease, Glucosylceramide Beta-Glucosidase Deficiency Disease
- Trial name
- NCT00358943
- Where
- 317 sites in United States, Argentina and 50 more
- Volunteers
- 12,000 people
- Sponsor
- Genzyme, a Sanofi Company
Head and Neck (HNSCC)
HYperfractionated Radiation Therapy Versus Concurrent Chemoradiation for Head and Neck Cancer (HYTC)
This is an international multi-centre, non-inferiority phase III randomized controlled trial comparing concurrent chemoradiation with high dose cisplatin (Arm A) vs.
- Trial name
- NCT07801235
- Testing
- 70 gy 35 fractions/7weeks+high dose of cisplatin, 81.6 Gy /68 fractions BID FOR 7 WEEKS
- Where
- Jordan
- Volunteers
- 604 people
- Sponsor
- King Hussein Cancer Center
Back Pain
Effect of Shock Wave Therapy With Core Stability Exercises for Treatment of Chronic Non-Specific Back Pain
To investigate the Effect of Combined Extracorporeal Shock Wave with core stability Exercise for the Treatment of Chronic Non-Specific Back Pain in Jordanian University Students
- Trial name
- ESW (NCT07319988)
- Testing
- Extracorporeal Shock wave therapy, Therapeutic ultrasound, core stabilization exercise
- Where
- 2 sites in Egypt, Jordan
- Volunteers
- 60 people
- Sponsor
- New Ismailia National University
Chronic Pelvic Pain Syndrome
Pulsed Electromagnetic Versus Hydrotherapy on Chronic Pelvic Pain
Pulsed electromagnetic field therapy and hydrotherapy are non-invasive treatment modalities that may alleviate chronic pelvic pain through pain modulation, reduction of inflammation, enhancement of circulation, and relaxation of…
- Trial name
- PEMF (NCT07867808)
- Testing
- pulsed electromagnetic field, hydrotherapy, traditional physical therapy program
- Where
- Jordan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Horus University
Anterior Knee Pain, Photobiomodulation (PBM)
Photobiomodultion in Anterior Knee Pain
The goal of this clinical trial is to assess the augmented recovery in the adolescent females with patellar tendinopathy using Phot- Biomodulation
- Conditions
- Anterior Knee Pain, Photobiomodulation (PBM), Laser Therapy
- Trial name
- PBM (NCT07865325)
- Testing
- Photobiomodultion with Laser scanning, patellar mobilization with exercise therapy
- Where
- Jordan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- New Ismailia National University
Adolescent Pregnancy
Effectiveness of a Digital Health Coaching on Pregnancy Outcome
Adolescent pregnancy can present health challenges for both mothers and their babies. Pregnant adolescents who are experiencing their first pregnancy may need additional support to develop healthy practices, manage…
- Trial name
- Coaching (NCT07865273)
- Testing
- Digital Health Coaching Self-Management Program
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Al-Zaytoonah University of Jordan
Gynecologic Cancer
Follow-up in Gynecological Cancer Survivors
A cross-sectional prospective study of follow-up in gynecologic cancer patients after primary treatment
- Trial name
- NCT03515993
- Where
- 21 sites in Austria, Belgium and 7 more
- Volunteers
- 1,100 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Benign Paroxismal Positional Vertigo
BPPV Recurrence After CRM With & Without Supplementation
Benign paroxysmal positional vertigo (BPPV) may frequently recur even after successful canalith repositioning maneuvers (CRMs). This study investigates whether the addition of vitamin K₂ to vitamin D₃ offers additional benefits…
- Trial name
- RR-BPPV-DK (NCT07861464)
- Testing
- Combined vitamin D₃ and K₂ supplementation, Vitamin D₃ alone, Canalith repositioning maneuver (CRM) alone
- Where
- Jordan
- Volunteers
- 404 people
- Sponsor
- University of Jordan