Clinical trials: in Lesotho
HIV
PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study
The PROvide MIner-friendly SErvices for Integrated TB/HIV Care (PROMISE) study will assess the effectiveness, feasibility, and acceptability of integrated tuberculosis (TB)/HIV services provided in miner-friendly service venues…
- Trial name
- PROMISE (NCT03537872)
- Testing
- Miner-Friendly (MF) Service Venues TB/HIV Integration Strategies, Public Sector (PS) Health Facilities TB/HIV Integration Strategies
- Where
- 5 sites in Lesotho
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preconception Care
Nthabi in Lesotho - Implementation
This project will determine how well the mobile health (mHealth) Nthabi application is introduced and used at district hospitals in Lesotho.
- Trial name
- NCT04354168
- Testing
- mHealth Application
- Where
- Lesotho
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV-1-infection
Dolutegravir in Real Life in Lesotho
DO-REAL is an observational cohort study assessing the large-scale roll-out of the antiretroviral drug dolutegravir (DTG) in Lesotho.
- Trial name
- DO-REAL (NCT04238767)
- Testing
- Dolutegravir
- Where
- 2 sites in Lesotho
- Volunteers
- 1,433 people
- Sponsor
- Swiss Tropical & Public Health Institute
Tuberculosis, Pediatric
TB Innovation Project: A Pre- and Post- Implementation Assessment (TIPPI)
This evaluation will be conducted in ten countries involved in the Catalyzing Pediatric TB Innovation (CaP-TB) project: Cameroon, Cote D'Ivoire, Democratic Republic of Congo, Kenya, Lesotho, Malawi, Tanzania, Uganda, Zimbabwe and…
- Trial name
- TIPPI (NCT03948698)
- Testing
- Innovative approached to pediatric TB care
- Where
- 10 sites in Cameroon, Côte d’Ivoire and 8 more
- Volunteers
- 4,159,533 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Multi-drug Resistant Tuberculosis
Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB Tuberculosis
PandrTB is a study of the pharmacokinetics(PK) and pharmacodynamics(PD) of bedaquiline, delamanid, clofazimine, linezolid, moxifloxacin, levofloxacin and pyrazinamide used in novel combinations to treat multidrug-resistant…
- Trial name
- PandrTB (NCT03827811)
- Where
- 7 sites in Kazakhstan, Lesotho and 4 more
- Volunteers
- 625 people
- Sponsor
- University of Cape Town
Arterial Hypertension
Identifying Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa
This study is to compare the effectiveness of three different antihypertensive treatment strategies for reaching a target blood pressure (clinic BP) of </= 130/80 mmHg among patients <65years of age and </= 140/90 mmHg among…
- Trial name
- coArtHA (NCT04129840)
- Testing
- dual combination, triple combination, Standard of care
- Where
- 3 sites in Lesotho, Switzerland and 1 more
- Volunteers
- 1,268 people
- Sponsor
- University Hospital, Basel, Switzerland
Tuberculosis, Multidrug-Resistant
Expand New Drugs for TB [endTB]
This observational study will examine the safety and efficacy of bedaquiline and delamanid used (individually, not together) in routine, multidrug regimens for treatment of MDR-TB.
- Trial name
- NCT03259269
- Testing
- This is a non-intervention observational study
- Where
- 16 sites in Armenia, Bangladesh and 12 more
- Volunteers
- 2,804 people
- Sponsor
- Partners in Health
Tuberculosis
Preventing Childhood Tuberculosis in Lesotho (PREVENT Study)
Lesotho, a small, landlocked country completely surrounded by South Africa, is among the world's poorest nations with one of the world's most severe epidemics of tuberculosis (TB) and HIV.
- Trial name
- NCT02662829
- Testing
- Community-based intervention, Standard of care
- Where
- 10 sites in Lesotho
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS
"Switch Either Near Suppression Or THOusand"
This trial addresses the question of the viral load (VL) threshold for switching from first-line to second-line antiretroviral therapy (ART). The WHO currently sets the threshold at 1000 copies/mL.
- Trial name
- SESOTHO (NCT03088241)
- Testing
- switch
- Where
- 8 sites in Lesotho
- Volunteers
- 80 people
- Sponsor
- Niklaus Labhardt
Tuberculosis, HIV
Start TB Patients on ART and Retain on Treatment (START Study)
The purpose of the START Study is to identify an effective, cost-effective, acceptable intervention that addresses programmatic, structural and psychosocial barriers to ART initiation and retention during TB treatment, with the…
- Trial name
- START (NCT01872390)
- Testing
- Combination Intervention Package, Standard of Care
- Where
- 12 sites in Lesotho
- Volunteers
- 415 people
- Sponsor
- Columbia University
HIV/AIDS
Peer-Educator-coordinated vs Nurse-coordinated ART Refill for Adolescents and Young Adults Living With HIV in Lesotho
Sub-Saharan Africa (SSA) is home to 85% of the adolescents and young people living with HIV (AYPLHIV) globally and they are heavily affected by the HIV/AIDS epidemic: AYPLHIV in SSA are the only population group for whom…
- Trial name
- PEBRA (NCT03969030)
- Testing
- PEBRA model
- Where
- 20 sites in Lesotho
- Volunteers
- 307 people
- Sponsor
- Amstutz Alain
HIV/AIDS
Village-based vs Clinic-based ART Care - a Cluster Randomized Controlled Trial in Lesotho
This cluster-randomized trial tests a differentiated care model for HIV-positive individuals not on ART during a home-based HIV testing campaign in rural Lesotho, Southern Africa.
- Trial name
- VIBRA (NCT03630549)
- Testing
- Standard of Care, Village-based ART refill
- Where
- 2 sites in Lesotho
- Volunteers
- 257 people
- Sponsor
- Niklaus Labhardt
Adherence, Medication, HIV/AIDS
Short Adherence Intervention for Viral Re-suppression
In the era of test-and-treat, with anticipated high numbers of patients who will have unsuppressed viral load (VL) due to poor adherence, simple, short and standardized adherence interventions with documented efficacy will be…
- Trial name
- SAVIR (NCT03242980)
- Testing
- Structured adherence counseling
- Where
- 12 sites in Lesotho
- Volunteers
- 928 people
- Sponsor
- Swiss Tropical & Public Health Institute
HIV, HIV/AIDS
HOme-based SElf-testiNG - a Cluster Randomized Controlled Trial in Rural Lesotho (HOSENG)
This cluster-randomized trial aims to evaluate the efficacy of the use of oral HIV self-testing (HIVST) among individuals who are absent or who decline HIV testing during home-based HIV testing
- Trial name
- HOSENG (NCT03598686)
- Testing
- OraQuick
- Where
- 2 sites in Lesotho
- Volunteers
- 10,000 people
- Sponsor
- Tracy Glass
HIV Infection
Same-day ART Initiation Versus Standard of Care After Positive HIV-test Result in Rural Lesotho
The CASCADE-trial is a two-armed open-label randomized controlled trial conducted in rural Lesotho. Participants who were tested HIV-positive during community-based HIV testing and counseling campaigns are randomized to the…
- Trial name
- CASCADE (NCT02692027)
- Testing
- Same-day ART initiation, Standard of care
- Where
- Lesotho
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
HIV/AIDS
Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision
The aim of this study is to evalulate the effectiveness and cost-effectiveness of three models of ART provision for stable ART patients.
- Trial name
- [MMD] (NCT03438370)
- Testing
- Three monthly ART supply at CAGs, Six monthly ART supply at outreaches
- Where
- Lesotho
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Equip, Lesotho
HIV, Metabolic Syndrome
Comorbidities and Virologic Outcome Among Patients on Anti-retroviral Therapy in Rural Lesotho
This study is conducted in a cohort of HIV-positive patients on first-line anti-retroviral therapy (ART) in rural health facilities in Lesotho, Southern Africa.
- Conditions
- HIV, Metabolic Syndrome, Depression, Alcoholism
- Trial name
- NCT02126696
- Where
- 2 sites in Lesotho
- Volunteers
- 1,754 people
- Sponsor
- Swiss Tropical & Public Health Institute
Social Stigma
Reducing Lesbian, Gay , Bisexual and Transgender (LGBT) Stigma in Swaziland and Lesotho
The specific objectives of this study are reduce stigma towards lesbian, gay, bisexual, and transgender persons in Swaziland and Lesotho, using performance ethnography at community roundtables.
- Trial name
- NCT02410434
- Testing
- LGBT Stigma Reduction Intervention
- Where
- 2 sites in Eswatini, Lesotho
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Enhanced HIV Prevention in Couples: Feasibility Study #1
The purpose of this study is to gather information needed to develop a large prevention trial to decrease the risk for HIV transmission among HIV-discordant couples (where one person is HIV-positive and the other is HIVnegative)…
- Trial name
- EPIC (NCT02027714)
- Where
- 4 sites in Lesotho
- Volunteers
- 230 people
- Sponsor
- Columbia University
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Enhanced Prevention in Couples: Feasibility Study #2
The purpose of this study is to gather information needed to develop a large prevention trial to decrease risk for Human immunodeficiency virus (HIV) transmission among HIV-discordant couples (where one person is HIV-positive and…
- Trial name
- EPIC (NCT02027441)
- Testing
- Standard Counseling and Testing
- Where
- 2 sites in Lesotho
- Volunteers
- 191 people
- Sponsor
- Columbia University