Clinical trials: in Malta
Breast Cancer
Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.
The purpose of this study is to evaluate the efficacy of a new dose of 500 mg Fulvestrant with the standard dose of 250 mg in postmenopausal women with oestrogen receptor positive advanced breast cancer who have failed on a…
- Trial name
- CONFIRM (NCT00099437)
- Testing
- Fulvestrant
- Where
- 106 sites in United States, Belgium and 15 more
- Volunteers
- 736 people
- Sponsor
- AstraZeneca
Crohn Disease
The CROCO Study: CROhn's Disease COhort Study
The investigators propose to create a prospective Crohn Disease cohort, where patients receiving the most up-to-date therapies with a treat-to-target strategy, will be closely followed to characterize the progression of Crohn…
- Trial name
- CROCO (NCT05420233)
- Testing
- MRE
- Where
- 19 sites in Belgium, Cyprus and 9 more
- Volunteers
- 533 people
- Sponsor
- GLSMED Learning Health S.A.
Diabetes Type 2, Heart Failure
RAPIDE: The Feasibility of a Hybrid Care Model
Rationale: During cross-border health emergencies, such as seen with the COVID-19 pandemic, health and care services are rapidly being overwhelmed by high numbers of patients requiring care, leading to stretches in the whole…
- Trial name
- NCT06735404
- Testing
- Hybrid care
- Where
- 4 sites in Italy, Malta and 2 more
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Sepsis, Septic Shock
Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis
Sepsis is a complex syndrome that causes lethal organ dysfunction due to an abnormal host response to infection. No drug specifically targeting sepsis has been approved.
- Trial name
- MENDSEP (NCT06287684)
- Where
- Malta
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Diabetes Mellitus, Hypertension
An International Prospective, Observational, Multi-centre Study on the Duration of Pre-operative Liquid Fasting
The investigators will be performing an international prospective, observational, multi-centre, cross-sectional study to determine the actual duration of preoperative liquid fasting time in European patients.
- Conditions
- Diabetes Mellitus, Hypertension, Ischaemic Heart Disease, Comorbidities and Coexisting Conditions
- Trial name
- THIRST (NCT06527703)
- Testing
- no intervention
- Where
- Malta
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis
DOAC in Unusual Site Venous Thrombosis
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein…
- Conditions
- Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis
- Trial name
- DUST (NCT03778502)
- Testing
- Direct Oral Anticoagulants
- Where
- 24 sites in United States, Canada and 8 more
- Volunteers
- 358 people
- Sponsor
- University of Malta
Celiac Disease
ICT Tools for the Diagnosis of Autoimmune Diseases
The ITAMA project, which ended in 03/2022, came from the need to increase/anticipate the number of diagnosed cases of celiac disease (CD).
- Trial name
- ITAMA_CAP (NCT05715970)
- Testing
- PoCT+questionnaire administration
- Where
- 2 sites in Italy, Malta
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Mid-Portion Achilles Tendinopathy
High Volume Injection in Mid Portion AChilles Tendinopathy
This prospective randomised clinical trial aims to evaluate the effectiveness of treatment for mid-portion Achilles tendinopathy in a real-world clinical setting, minimising the excessive control typically associated with…
- Trial name
- HighIMPACT (NCT06774066)
- Testing
- High volume image guided injection, Progressive rehabilitation exercise programme
- Where
- Malta
- Volunteers
- 20 people
- Sponsor
- University of Malta
Cardiac Disease, Coronary Artery Bypass
Distraction Therapy Using Virtual Reality in Cardiac Rehabilitation
The European Society of Cardiology has been putting forward the need for new adjuncts or models that optimise outcomes from CR programmes.
- Trial name
- NCT06898827
- Testing
- IVR using the Morpheus Programme, Cardiac Rehabilitation control group
- Where
- Malta
- Volunteers
- 20 people
- Sponsor
- University of Malta
Diabetes Mellitus, Tobacco Use Cessation
Feasibility of a Diabetes Specialist Nurse-led Smoking Cessation Intervention
The goal of this clinical trial is to assess the feasibility and acceptability of a multi-component smoking cessation intervention for individuals living with diabetes which is delivered by diabetes specialist nurses.
- Trial name
- NCT05920096
- Testing
- Diabetes specialist nurse-led multi-component smoking cessation intervention, Health Promotion and Disease Prevention Directorate's one-to-one smoking cessation service (standard care)
- Where
- Malta
- Volunteers
- 91 people
- Sponsor
- University of Malta
Breast Cancer
Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using either tamoxifen or anastrozole may fight breast cancer by blocking the use of estrogen.
- Trial name
- IBIS-II DCIS (NCT00072462)
- Testing
- tamoxifen citrate, Anastrozole
- Where
- 97 sites in Australia, Austria and 12 more
- Volunteers
- 2,980 people
- Sponsor
- Queen Mary University of London
Congenital Heart Disease
Assessment of Patterns of Patient Reported Outcomes in Adults With Congenital Heart Disease - International Study II
This is an international, cross-sectional and descriptive study that aims to investigate differences in patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) and that aims to explore the…
- Trial name
- APPROACH-IS II (NCT04902768)
- Testing
- This is an observational study, there is no intervention
- Where
- 53 sites in United States, Argentina and 30 more
- Volunteers
- 8,415 people
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease
Assessing the Utility of Peak Inspiratory Flow as a Predictor for COPD Exacerbations
This is an international, mulitcentre, observational, prospective study into Peak Inspiratory Flow in COPD patients that aims to: A) Determine the prevalence of suboptimal Peak Inspiratory Flow (PIF) and inadequate inhaler choice…
- Trial name
- NCT04360226
- Testing
- Non-interventional
- Where
- 13 sites in Italy, Malta and 4 more
- Volunteers
- 400 people
- Sponsor
- Respiratory Effectiveness Group
Facial Pain
Phenotype and Burden of a Midfacial Segment Pain
The purpose of this study is to describe midfacial segment pain phenotype, burden and comorbidities in a multicentre and multidisciplinary setting.
- Trial name
- NCT06299995
- Where
- 13 sites in Malta, Poland and 1 more
- Volunteers
- 200 people
- Sponsor
- Swiat Zdrowia
Heart Failure
MOre REsponse on Cardiac Resynchronization Therapy With MultiPoint Pacing
The purpose of this Clinical investigation is to assess the impact of the Multi Point Pacing (MPP) feature at 12 months in the treatment of patients not responding to standard Cardiac Resynchronization Therapy (CRT) after 6…
- Trial name
- MORE CRT MPP (NCT02006069)
- Testing
- MPP
- Where
- 206 sites in United States, Australia and 28 more
- Volunteers
- 5,850 people
- Sponsor
- Abbott Medical Devices
Covid19, COVID-19 Pneumonia
The Long Term Effects of COVID on Pulmonary Function
An observational cohort study of patients discharged from the ICU following admission with COVID19 infection, looking at their medical wellbeing 6 months after discharge from the ICU.
- Conditions
- Covid19, COVID-19 Pneumonia, Critical Illness, Quality of Life
- Trial name
- NCT05077982
- Testing
- Spirometry, 6-minute walk
- Where
- 2 sites in Malta
- Volunteers
- 123 people
- Sponsor
- Sciberras, Stephen M.D.
COVID-19 Pneumonia, ARDS
The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumonia
This study aims to establish whether tocilizumab has any significant effect on procalcitonin levels on patients diagnosed with COVID-19 pneumonia requiring intensive care admission.
- Trial name
- NCT05035589
- Testing
- Tocilizumab
- Where
- Malta
- Volunteers
- 100 people
- Sponsor
- Sciberras, Stephen M.D.
Syncope
The Management of Transient Loss of Consciousness and Suspected Syncope in European Emergency Departments
Prospective multi centre cohort study examining the clinical presentation, diagnostic tests, and management of adult Emergency Department (ED) patients presenting with Transient Loss of Consciousness (TLOC) either…
- Trial name
- SEED (NCT05571254)
- Testing
- Data collection
- Where
- 57 sites in Albania, Austria and 16 more
- Volunteers
- 952 people
- Sponsor
- NHS Lothian
COVID-19
Pan-European Study on Geriatric Rehabilitation After COVID-19 Disease
Older and more vulnerable persons are more likely to get very ill when infected with the coronavirus, and have the highest COVID-19 morbidity and mortality rate.
- Trial name
- EU-COGER (NCT05749731)
- Where
- 51 sites in Czechia, Germany and 8 more
- Volunteers
- 723 people
- Sponsor
- Leiden University Medical Center
Osteoarthritis, Hip
Relationship of Core Stability on Pain and Functional Levels in Patients Diagnosed With Hip Osteoarthritis
Osteoarthritis (OA) is a common disease that occurs more commonly amongst the elderly and is caused by the destruction of the joint cartilage.
- Trial name
- NCT04771936
- Testing
- Physiotherapy Exercises
- Where
- Malta
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Malta