Clinical trials: in Pakistan
Inborn Errors of Metabolism, Biomarker
Biomarkers for Inborn Errors of Metabolism
International, multicenter, observational, longitudinal study to identify or monitor Inborn Error of Metabolism disease biomarkers and to explore the clinical robustness, specificity, and long-term variability of these biomarkers
- Trial name
- BioMetabol (NCT04098198)
- Where
- 13 sites in Albania, Egypt and 6 more
- Volunteers
- 462 people
- Sponsor
- CENTOGENE GmbH Rostock
Diabetes Mellitus, Type 2, NASH - Nonalcoholic Steatohepatitis
Effect of Oral Anti-diabetic Medication on Liver Fat in Subjects With Type II Diabetes and Non-alcoholic Fatty Liver
This randomized clinical trial aims to compare the effect of the pioglitazone and SGLT2 inhibitor combination on liver fat mass, as compared to either drug used alone, with or without background medical therapy of metformin…
- Conditions
- Diabetes Mellitus, Type 2, NASH - Nonalcoholic Steatohepatitis, NAFLD
- Trial name
- NCT04976283
- Testing
- Pioglitazone, Empagliflozin, Pioglitazone + Empagliflozin
- Where
- Pakistan
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Getz Pharma
COVID-19
Efficacy and Safety of Apixaban in COVID-19 Coagulopathy Patients With Respiratory Severity Under Critical Care
The purpose of the study is to describe the safety and efficacy outcomes of a cohort of ICU patients with severe COVID-19 respiratory disease treated with therapeutic dose Apixaban for COVID-19 at a tertiary public health care…
- Trial name
- ECRU (NCT05088928)
- Testing
- Apixaban, Rivaroxaban
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Scotmann Pharmaceuticals
Prevention of COVID-19, Safety and Efficacy
A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19
A randomized, double-blind, placebo-controlled international multicenter clinical trial design will be adopted. A total of 29,000 subjects aged 18 years and above are planned to be recruited, including 750 subjects aged 18-59…
- Trial name
- NCT04646590
- Testing
- Recombinant new coronavirus vaccine (CHO cell) group
- Where
- 18 sites in China, Ecuador and 3 more
- Volunteers
- 28,904 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Musculoskeletal Disorder, Pain Management
Safety & Efficacy of Nuberol Forte® in Pain Management
The global prevalence of Musculoskeletal disorders (MSD) ranges from 14% to as high as 42%. In addition WHO also estimates that 40% of people over the age of 60 years suffer from MSD and about 80% of the people have had low back…
- Trial name
- NFORT-EFFECT (NCT04765787)
- Testing
- Combination of Paracetamol 650mg + Orphenadrine 50mg
- Where
- 3 sites in Pakistan
- Volunteers
- 399 people
- Sponsor
- The Searle Company Limited Pakistan
Neoplasms, Breast
Neo ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation) Study
This is a randomised, open label multicenter Phase III study comparing the efficacy of neoadjuvant lapatinib plus paclitaxel, versus trastuzumab plus paclitaxel, versus concomitant lapatinib and trastuzumab plus paclitaxel given…
- Trial name
- Neo ALTTO (NCT00553358)
- Testing
- Lapatinib, Trastuzumab, Paclitaxel
- Where
- 121 sites in Argentina, Belgium and 22 more
- Volunteers
- 455 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Neck Pain
Effects of Cervical Proprioceptive Training in CMNP
It is a randomized control trial will be conducted at Federal Government Polyclinic hospital on 44 chronic mechanical neck pain patients. Patients will be recruited in the study through non probability purposive sampling.
- Trial name
- NCT04941495
- Testing
- conventional physiotherapy, Cervical proprioceptive training
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Mir Arif Hussain
Homocystine; Metabolic Disorder
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan
Raised plasma Homocysteine (Hcy) was 1st proposed as a cause of vascular pathology in patients with inherited disorders of Homocysteine metabolism.leading to the hypothesis that individuals with slight to moderate elevated levels…
- Trial name
- NCT05011032
- Testing
- Homocysteine
- Where
- Pakistan
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Osteo Arthritis Knee
Effects of Compression Mobilization in OA Patients
The study Design was randomized control trial in which data was collected From Riphah Rehabilitation And Research Center and Pakistan Railway Hospital-IIMCT. Convenient sampling technique was used for data collection.
- Trial name
- NCT04944056
- Testing
- conventional physiotherapy, compression mobilization
- Where
- Pakistan
- Volunteers
- 39 people
- Sponsor
- Mir Arif Hussain
Ventilation Therapy; Complications
Diaphragmatic Mobility In Ventilated Assisted Patients
The study was a randomized controlled trial. A total of 24 patients who met the inclusion criteria were included in this study and randomly divided by sealed envelope method into Experimental and Control groups with 12 patients…
- Trial name
- NCT04733261
- Testing
- Diaphragmatic mobility, Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Radiculopathy Lumbar
Spinal Decompression Therapy in Radicular Chronic Low Back Pain
The study design was randomized control trial and sampling technique was lottery method. After inclusion and exclusion criteria, sample populations were divided into experimental (group A) and control group (group B).
- Trial name
- NCT04701879
- Testing
- Spine decompression with core stability exercises, Spine decompression
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Lumbar Radiculopathy
Effects of ELDOA in Lumber Radiculopathy
ELDOA is the most beneficial intervention treating for lumbar pathologies such as radiculopathy. This study was a randomized control trial in which data was collected from Riphah Rehabilitation and Research Centre and Pakistan…
- Trial name
- NCT04681716
- Testing
- ELDOA, CONVENTIONAL PHYSIOTHERAPY
- Where
- Pakistan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Lumbar Disc Herniation
Compare the Effects of Decompression on Lumber Disc Protrusion Patient
This is an RCT study in which 60 participant are included and half of the participant are randomized via lottery method in control and experimental group after fulfilling the inclusion criteria.
- Trial name
- NCT04860609
- Testing
- Conventional Physiotherapy, Lumber Spinal Decompression
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Lumbar Disc Herniation
Effect of Decompression With and Without ELDOA in Lumber Disc Protrusion Patients
The study will be conducted to determine the effects of spinal decompression with and without ELDOA in patients of lumbar disc protrusion.
- Trial name
- ELDOA (NCT04930523)
- Testing
- Elongation Longitudinaux Avec Decoaption Osteo Articulaire, Decompression
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Lumbar Disc Herniation, Spinal Disk Injury
Decompression With ELDOA on Lumbar Disc Protrusion Patient
Decompression therapy is a result-oriented approach but it expensive and minimum availability in Pakistan. In physical therapy, we use different exercises to solve multiple spine problems.
- Conditions
- Lumbar Disc Herniation, Spinal Disk Injury, Protrusion
- Trial name
- NCT04760210
- Testing
- Control Group, Decompression Group, ELDOA
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Lysosomal Storage Diseases, Gaucher Disease
Lyso-Gb1 as a Long-term Prognostic Biomarker in Gaucher Disease
International, multicenter, epidemiological study to demonstrate the correlation and predictive value of lyso-Gb1 concentration with the clinical severity of naïve, initially non-ERT/SRT Gaucher disease type 1 and during the…
- Conditions
- Lysosomal Storage Diseases, Gaucher Disease, Sphingolipidoses
- Trial name
- LYSO-PROOF (NCT02416661)
- Where
- 8 sites in Albania, Greece and 5 more
- Volunteers
- 299 people
- Sponsor
- CENTOGENE GmbH Rostock
Breast Neoplasms
A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
This multicenter, two-cohort, non-randomized, open-label study will evaluate the safety and tolerability of assisted and self-administered SC Herceptin as adjuvant therapy in participants with early HER2-positive breast cancer…
- Trial name
- SafeHER (NCT01566721)
- Testing
- Herceptin
- Where
- 437 sites in Albania, Algeria and 57 more
- Volunteers
- 2,577 people
- Sponsor
- Hoffmann-La Roche
Neck Pain
kINESIOTAPING ON PATIENT'S FUNCTIONAL STATUS IN NON-SPECIFIC NECK PAIN
The objective of the study is to find the effectiveness of kinesiotaping on the patient's functional status in non-specific neck pain.
- Trial name
- NCT04733248
- Testing
- Kinesiotaping group, stretching group
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Wilson Disease
Establishment of Human Cellular Disease Models for Wilson Disease
Establishment of human cellular disease models for Wilson disease for an individualized therapy develop-ment having the capacity to address both hepatic and neurologic forms of the disease
- Trial name
- IPSWILSON (NCT03867526)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- CENTOGENE GmbH Rostock
Morquio Disease
Establishment of Human Cellular Disease Models for Morquio Disease
Establishment of human cellular disease models for Morquio disease for an individualized therapy development having the capacity to address both hepatic and neurologic forms of the disease
- Trial name
- IPSMORQUIO (NCT03872713)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- CENTOGENE GmbH Rostock