Clinical trials: in Pakistan
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
PRISM Trial: Partial Breast Versus Whole Breast Radiation in Early Breast Cancer
Breast-conserving surgery followed by radiotherapy is a standard treatment for women with early-stage breast cancer. Whole breast irradiation (WBI) is the current standard approach, but partial breast irradiation (PBI), which…
- Trial name
- PRISM (NCT07811635)
- Testing
- Ultra-Hypofractionated Partial Breast Irradiation, Ultra-Hypofractionated Whole Breast Irradiation
- Where
- 3 sites in Pakistan, Saudi Arabia and 1 more
- Volunteers
- 100 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Oral Submucous Fibrosis
Curcumin Plus Topical Steroid Versus Topical Steroid Alone for Oral Submucous Fibrosis
This study evaluates whether combining oral curcumin (a natural compound derived from turmeric) with a topical steroid is more effective than using a topical steroid alone in treating Oral Submucous Fibrosis (OSMF).
- Trial name
- NCT07891130
- Testing
- Curcumin and and triamcinolone acetonide, Triamcinolone Acetonide
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Knee Arthritis Osteoarthritis, Neuromuscular Adaptations
Effects Of Sensor Assisted Neuro-muscular Exercise Vs Electrical Stimulation On Bio-mechnical And Functional Parameters In Grade II And III Knee Osteoarthritis.
This two-arm randomized controlled trial compared Sensory-Assisted Neuromuscular Exercise (Group A) with Electrical Stimulation (Group B) in 40 adults aged 40-65 with Kellgren-Lawrence Grade II-III knee osteoarthritis, recruited…
- Trial name
- NCT07891351
- Testing
- Sensory-Assisted Neuromuscular Exercise, Electrical stimulation
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ziauddin University
Neonatal Respiratory Distress Syndrome
Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature Neonates
Newborn babies who have difficulty breathing may need breathing support to help them receive enough oxygen. Two commonly used methods are heated, humidified high-flow nasal cannula (HHFNC), which delivers warmed, moist air and…
- Trial name
- NCT07891494
- Testing
- Heated Humidified High-Flow Nasal Cannula therapy, nCPAP
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Liver Biomarkers, Glucose
Modulatory Effects of Resveratrol Supplement Along With and Without Low Glycemic Index Diet Among Obese Patients With Diabetic Nephropathy
This 12-week randomized controlled trial evaluated the effects of resveratrol supplementation with and without a low glycemic index (LGI) diet in obese patients with diabetic nephropathy.
- Conditions
- Liver Biomarkers, Glucose, Lipid Profiles
- Trial name
- NCT07891975
- Testing
- T0 starch capsule, T1 resveratrol capsule, T2 300 mg per day along with a low glycemic index diet, TWICE A DAY
- Where
- Pakistan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Computer Vision Syndrome
Comparative Effects of Exercises on Pain, Cervical Proprioception, Neck Disability and Visual Performance in Patients With Computer Vision Syndrome.
This study aims to compare the effectiveness of cervical sensorimotor training and oculomotor training in patients with Computer Vision Syndrome (CVS).
- Trial name
- NCT07892040
- Testing
- Cervical Sensorimotor Training, Occulomotor Training
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- University of Management and Technology Lahore
Back Pain
Comparative Effects of Soft Tissue Mobilization and Pressure Therapy With and Without Dynamic Cupping on on Pain and Disability in Patients With Thoracic Back Pain.
This study aims to compare the sequential effects of Instrument-Assisted Soft Tissue Mobilization (IASTM) and Transverse Oscillatory Pressure (TOP), with and without Directional Dynamic Cupping, in patients with thoracic back…
- Trial name
- NCT07892066
- Testing
- Instrument assisted soft tissue (IASTM), Transvers oscillatory pressure (TOP), Instrument assisted soft tissue (IASTM), Transvers oscillatory pressure (TOP) and Directional dynamic cupping
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Management and Technology Lahore
Low Back Pain
Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE)
This study aims to compare the effects of Motor Control Exercises (MCE) with and without Pressure Biofeedback-Guided Training in patients with recurrent low back pain.
- Trial name
- yes (NCT07892079)
- Testing
- Motor Control Exercise with Pressure Biofeedback-Guided Training, Motor Control Exercise
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Management and Technology Lahore
Text Neck Syndrome
Effects of Progressive Neck Motor Control Exercises With and Without Conventional Therapy in Text Neck Syndrome.(PNMCE-TNS)
This study aims to compare the effects of Progressive Neck Motor Control Exercises (PNMCE) with and without conventional physiotherapy in patients with Text Neck Syndrome.
- Trial name
- Yes (NCT07892131)
- Testing
- Progressive Neck Motor Control Exercises, Progressive Neck Motor Control Exercises and Conventional Therapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- University of Management and Technology Lahore
Knee Osteoarthritis
Effects of Low-Load Blood Flow Restriction Resistance Training With and Without Hip Abductor Strengthening in Patients With Knee Osteoarthritis.(BFR)
This study aims to compare the effects of low-load Blood Flow Restriction (BFR) resistance training with and without hip abductor strengthening in patients with knee osteoarthritis.
- Trial name
- yes (NCT07892144)
- Testing
- Hip Abductor Strength Training followed by Low-Load BFR Resistance Training, Low-Load Blood Flow Restriction (BFR) Resistance Training
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- University of Management and Technology Lahore
Gingivitis
Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for Gingivitis
The goal of this clinical trial is to learn if daily oil pulling with coconut oil or sesame oil works as effectively as a standard mouthwash to treat gum swelling and redness (gingivitis) in adults aged 18 to 55 years.
- Trial name
- NCT07892235
- Testing
- virgin coconut oil (VCO), Sesame Oil, 0.2% Chlorhexidine Digluconate Mouthwash
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Bahria University
Generalised Anxiety Disorder, Anxiety
Effectiveness of Single-Session Acceptance and Commitment Therapy for Generalized Anxiety Symptoms.
This study examined whether a single 120-minute, therapist-led Acceptance and Commitment Therapy (SS-ACT) session, delivered individually and face-to-face in Urdu, was associated with reduced generalized anxiety symptoms among…
- Trial name
- SS-ACT (NCT07892768)
- Testing
- Single-Session Acceptance and Commitment Therapy (SS-ACT)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- GIFT University
Exercise Activity
Effect of a 12-Week Aerobic Exercise Program on Cardiac, Respiratory, Metabolic Health and Functional Fitness in Healthy Young Adults
This randomized controlled trial evaluated the effects of a structured 12-week multicomponent exercise program with an aerobic emphasis on cardiovascular, respiratory, metabolic, and functional fitness outcomes in healthy…
- Trial name
- NCT07892781
- Testing
- Structured Multicomponent exercise intervention program
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Chronic Hepatitis Delta Virus Infection
A Study to Assess Efficacy and Safety of HH-003 Injection in Subjects With Chronic Hepatitis Delta Virus Infection
This is a multicenter, randomized, controlled, open-label, Phase IIb study of HH-003 injection, HH-003 injection is a monoclonal antibody targeting Hepatitis B virus.
- Trial name
- NCT05861674
- Testing
- HH-003(20mg/kg), HH-003(10mg/kg), TAF
- Where
- 7 sites in China, Pakistan
- Volunteers
- 101 people
- Sponsor
- Huahui Health
Arthritis, Fibromyalgia
Wearable Biofeedback Devices for Remote Physiotherapy and Rehabilitation
This study evaluates the effectiveness of wearable biofeedback devices in improving pain, mobility, and rehabilitation outcomes in elderly patients with arthritis and fibromyalgia in Karachi, Pakistan.
- Conditions
- Arthritis, Fibromyalgia, Chronic Pain
- Trial name
- NCT06960330
- Testing
- Wearable Biofeedback + Virtual Physiotherapy, Standard Physiotherapy Exercises
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- University of Karachi
Symptomatic Irreversible Pulpitis
Comparison of Postoperative Pain After Root Canal Irrigation in Symptomatic Irreversible Pulpitis
This randomized controlled trial will compare postoperative pain following root canal treatment in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT07821359
- Testing
- Dexamethasone, Sodium Chloride 0.9%
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Acne Vulgaris
Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris
This study will compare the effectiveness and safety of topical clascoterone 1% cream and adapalene 0.1% cream in patients with mild-to-moderate acne vulgaris.
- Trial name
- NCT07883538
- Testing
- Clascoterone 1% cream, Adapalene 0.1% cream
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Pak Emirates Military Hospital
Neonatal Sepsis, Neutropenia
G-CSF In Neonatal Sepsis With Neutropenia
This study will evaluate whether adding G-CSF to standard treatment improves outcomes in newborns (0-28 days) with sepsis and neutropenia.
- Trial name
- NCT07888829
- Testing
- Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- University of Health Sciences Lahore
Aphasia
Learning to Communicate Successfully Approach for Urdu Speaking Patients With Chronic Aphasia
This study aims to develop and validate the Learning to Communicate Successfully Approach (LCSA), a culturally sensitive communication intervention manual for Urdu-speaking adults with chronic aphasia.
- Trial name
- LCSA (NCT07889778)
- Testing
- Learning to Communicate Successfully Approach (LCSA)
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Lahore
Antenatal Care Model, Gestatiaonl Diabetes Mellitus
Effects Of Core Canister Training in Pregnant Women With History of Gestational Diabetes Mellitus
This randomized control trial aims to determine the effects of structured Core Canister Training on muscular thickness, lumbopelvic stability and pelvic floor function in pregnant women diagnosed with GDM
- Trial name
- NCT07889791
- Testing
- core canister training, traditional antenatal exercises
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lahore
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