Clinical trials: in Pakistan
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Atrial Fibrillation, Atrial Flutter
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)
The prevention of perioperative atrial fibrillation (AF) and myocardial injury after non-cardiac surgery (MINS) has the potential to reduce mortality, stroke, and hospital stays in patients undergoing major thoracic surgery.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- COP-AF (NCT03310125)
- Testing
- Active Colchicine
- Where
- 46 sites in United States, Austria and 9 more
- Volunteers
- 3,209 people
- Sponsor
- Population Health Research Institute
Spinal Deformity
Spinal Deformity Intraoperative Monitoring.
A multicenter, international prospectively collected patient cohort undergoing high-risk spinal cord level surgery or spinal osteotomy procedures will be enrolled to establish the incidence of intraoperative alerts in high-risk…
- Trial name
- NCT03880292
- Testing
- Document intraoperative Maneuvers
- Where
- 24 sites in United States, Australia and 12 more
- Volunteers
- 592 people
- Sponsor
- AO Foundation, AO Spine
Hepatitis D, Chronic
A Study to Evaluate Pegylated Interferon Lambda Monotherapy in Patients With Chronic Hepatitis Delta Virus Infection
To evaluate safety and tolerability of lambda over a 48-week treatment period in HDV patients.
- Trial name
- LIMT (NCT02765802)
- Testing
- Peginterferon Lambda-1A
- Where
- 4 sites in Israel, New Zealand and 1 more
- Volunteers
- 33 people
- Sponsor
- EIT Pharma, Inc.
SARS-CoV-2 Infection
A Study to Compare S-217622 With Placebo in Non-Hospitalized Participants With COVID-19
The main aim of this study is to evaluate the efficacy of S-217622 versus placebo among outpatient adults with mild and moderate COVID-19 starting intervention within 3 days of symptom onset.
- Trial name
- SCORPIO-HR (NCT05305547)
- Testing
- S-217622
- Where
- 196 sites in United States, Argentina and 15 more
- Volunteers
- 2,093 people
- Sponsor
- Shionogi
Dry Eye, Insulin Sensitivity
Topical Insulin for Ocular Surface Interface in Dry Eye Disease
This is a parallel randomized controlled trial for the treatment of dry eye disease. The main objective is to investigate the efficacy and safety of the use of insulin eye drops in the control of moderate-severe dry eye disease.
- Trial name
- NCT06939959
- Testing
- Artificial tear, insulin human
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Khyber Teaching Hospital
Glenohumeral Internal Rotation Deficit (GIRD)
Effect of Joint Mobilization and Movement Control Exercises on Shoulder Pain and Function in Fast Bowlers (RCT)
The goal of this clinical trial is to determine combined effects of the Kinetic control for shoulder on pain, range, and function among fast bowlers.
- Trial name
- RCT (NCT07229274)
- Testing
- Kinetic control for shoulder internal rotation with mobilization with movement, stretches, strengthening and mobilization with movement
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Symptomatic Irreversible Pulpitis, Post Operative Pain
Effect of Preoperative Tramadol and Naproxen Sodium on Post Operative Pain
The goal of this clinical trial is to compare in Tramadol, Naproxen sodium and Placebo in participants presenting with irreversible pulpitis in their mandibular molar teeth.
- Trial name
- NCT05982392
- Testing
- Tramadol, Naproxen Sodium
- Where
- Pakistan
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Chronic Actinic Dermatitis
Comparison of Efficacy of Methotrexate and Azathioprine in Patients With Chronic Actinic Dermatitis: A Randomized Controlled Trial
The aim of this study is to evaluate the efficacy and safety of AZT and MTX in patients with Chronic Actinic Dermatitis (CAD). These drugs have been used successfully as steroid-sparing alternatives in a variety of related…
- Trial name
- NCT06476366
- Testing
- Azathioprine, Methotrexate
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Pak Emirates Military Hospital
Delirium
Delirium and EuroSCORE II in Cardiac Surgery
The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery.
- Trial name
- NCT05218720
- Testing
- EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Vaginal Birth After Cesarean Section
Role of Membrane Sweeping on Initiation of Labor and Vaginal Birth in Previous Cesarean Section
In Pakistan rate of child birth through cesarean section increased from 3.2% in 1992 to 22% in 2018 .Due to increasing rates of cesarean sections and associated morbidity the investigators should focus to reduce rate of primary…
- Trial name
- NCT06103071
- Testing
- Sweeping of membranes
- Where
- Pakistan
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- HITEC-Institute of Medical Sciences
Pneumonia, Ventilator-Associated
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding…
- Trial name
- NCT06039995
- Testing
- Comprehensive Oral Care, Traditional Oral Care, Mechanical Tooth Brushing using 0.2% Chlorhexidine
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Corona Virus Infection
A Pilot Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19
Primary Objective: To evaluate overall safety and tolerability of SIR1-365 in patients with severe COVID-19 Secondary Objectives: To assess the clinical efficacy of SIR1-365 in patients with severe COVID-19 To assess the effects…
- Trial name
- NCT04622332
- Testing
- SIR1-365
- Where
- 9 sites in United States, Mexico and 1 more
- Volunteers
- 45 people
- Sponsor
- Sironax USA, Inc.
Chronic Hepatitis C Virus, Hepatitis C, Chronic
A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV
This is an open-label trial to evaluate safety and efficacy of treatment with BEM + RZR in subjects with chronic HCV infection.
- Conditions
- Chronic Hepatitis C Virus, Hepatitis C, Chronic, Hepatitis C, Hepatic Cirrhosis
- Trial name
- NCT05904470
- Testing
- Bemnifosbuvir, Ruzasvir
- Where
- 51 sites in United States, Brazil and 10 more
- Volunteers
- 275 people
- Sponsor
- Atea Pharmaceuticals, Inc.
Strength, Range of Motion
Low-Load Blood Flow Restriction Training vs Traditional Resistance Training Exercises Following ACLR Surgery
The main objective/s of the study is to compare the effectiveness of low load blood flow restriction training (LL-BFR) with traditional resistance training exercises (T-RT) at improving skeletal muscle hypertrophy, strength…
- Conditions
- Strength, Range of Motion, Pain-Knee, Skeletal Muscle Hypertrophy
- Trial name
- NCT06480032
- Testing
- Blood Flow Restriction band
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Abasyn University Peshawar
Perinatal Depression, Perinatal Anxiety
Cognitive Behavioral Couple Therapy for Perinatal Distress
The hypotheses of the study are There will be differences in perceived perinatal distress, dyadic coping strategies, social support, domains of quality of life, and well-being in couples at Pre- and Post-Test levels during the…
- Trial name
- NCT06001021
- Testing
- Psychopharmacological Intervention, Cognitive Behavioral Couple Therapy, Combination of Psychopharmacological Intervention and CBCT
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Sameera Shafiq
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2 Infection), COVID-19
SUNRISE-3: Efficacy and Safety of Bemnifosbuvir in High-Risk Outpatients With COVID-19
The purpose of the study is to evaluate whether bemnifosbuvir (BEM) is effective and safe in adults with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease.
- Trial name
- NCT05629962
- Testing
- Bemnifosbuvir (BEM)
- Where
- 263 sites in United States, Argentina and 17 more
- Volunteers
- 2,285 people
- Sponsor
- Atea Pharmaceuticals, Inc.
Hypocalcemia After Total Thyroidectomy, Hypocalcemia
A Comparative Analysis of Hypocalcemia Incidence in Patients Undergoing Thyroidectomy: Ligasure vs Conventional Ligation of Vessels by Knot Tying
This study aims to address the existing gap in knowledge by conducting a comprehensive comparison of the incidence of hypocalcemia in patients undergoing thyroidectomy using Ligasure versus conventional ligation of vessels by…
- Trial name
- THYROIDECTOMY (NCT06716632)
- Testing
- Using Ligasure for heamostasis, Use of conventional knot tying technique for heamostasis
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Gulab Devi Hospital
Post-Partum Haemorrhage
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family.
- Trial name
- E-MOTIVE (NCT04341662)
- Testing
- E-MOTIVE intervention, Usual care
- Where
- 6 sites in Kenya, Nigeria and 3 more
- Volunteers
- 99,659 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Neoplasms, Breast
ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D
This was a four-arm (parallel group) randomized, open-label, multicenter Phase 3 study to investigate the use of a combination of Lapatinib and Trastuzumab, a sequence of Trastuzumab followed by Lapatinib, and Lapatinib alone…
- Trial name
- ALTTO (NCT00490139)
- Testing
- Lapatinib, Trastuzumab
- Where
- 924 sites in United States, Argentina and 42 more
- Volunteers
- 8,381 people
- Sponsor
- Novartis Pharmaceuticals