Clinical trials: completed, in Reunion
Atopic Dermatitis, Eczema, Atopic
Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis
The goal of this clinical trial is to compare a step-down strategy of spacing dupilumab injections with a standard maintenance treatment in adolescents and adults with controlled Atopic dermatitis (AD) for at least six months.
- Trial name
- MADULO (NCT05642208)
- Testing
- Dupilumab step-down
- Where
- 32 sites in France, Reunion
- Volunteers
- 256 people
- Sponsor
- Nantes University Hospital
Running, Motivation for Physical Activity
Study of the Psychological, Physiological and Biomechanical Responses to Trail Running in a Hot, Humid Environment
The determinants of trail performance have been extensively studied, and the results have revealed the significant influence of physiological, psychological and biomechanical parameters.
- Conditions
- Running, Motivation for Physical Activity, Sport Physiology
- Trial name
- RP2B-Trail (NCT07831109)
- Testing
- Trail running of 28km and 2580m vertical drop
- Where
- Reunion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Lipodystrophy, Dunnigan Syndrome
Impact of Lipodystrophy on the Inflammatory State of Non-diabetic Dunnigan Reunion Island Subjects
Few data and small numbers affect the inflammatory profile of Dunnigan patients. The levels of certain pro-inflammatory biomarkers would be found higher in these subjects compared to control individuals.
- Trial name
- LIPOKINES (NCT06107439)
- Testing
- Bood and urine sampling
- Where
- Reunion
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
HIV Infections
Study Among People Living With HIV and Their Health Professionals of Associated Factors of Resilience to Self-stigma
This study is perform to study the effect of psychological and psychosocial factors associated with resilience to the self-stigmatization of people living with HIV
- Trial name
- RESILSTIGMA (NCT05149001)
- Where
- 43 sites in France, Guadeloupe and 1 more
- Volunteers
- 667 people
- Sponsor
- University Hospital, Clermont-Ferrand
Leptospirosis
Chronic Post-leptospirosis Manifestations in Reunion
Leptospirosis is a zoonosis caused by spirochetes, pathogenic bacteria of the genus Leptospira. It is transmitted to humans through mucocutaneous lesions by contact with water or soil contaminated by the urine of animal…
- Trial name
- LEPTONIC (NCT05436756)
- Testing
- Biological sampling and collection
- Where
- 4 sites in France, Reunion
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Lipodystrophy
Assess the Possibility of Diagnosing Diabetes and Rediabetes Following Oral Induced Hyperglycemia in Patients With Dunnigan's Partial Familial Lipodystrophy by Replacing 75 g of Glucose With a Standardized Carbohydrate Breakfast and Continuous Interstitial Monitoring Glucose)
Dunnigan's syndrome is a partial familial lipodystrophy due to a mutation in the Lamine A LMNA gene. This very rare syndrome is 20 times more common in Réunion compared to the rest of Europe with several families suffering from a…
- Trial name
- HGPO-DUN (NCT05789251)
- Testing
- Standardized breakfast
- Where
- Reunion
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Contraception Behavior
SAPLAI : Assessing the faiSAbility of a Peer-to-peer Contraceptive Education Program on Social Networks Aimed at 15- to 19-year-old High School Students in GuAdeloupe and La RéunIon
The goal of this clinical trial is to evaluate the feasibility of a contraception education program delivered by peers via social networks to high school students.
- Trial name
- SAPLAI (NCT06943209)
- Testing
- Creation of a contraception education program and post on social networks for high school students, Education program, Survey and questionnaires
- Where
- 2 sites in Guadeloupe, Reunion
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Very Preterm Birth
EPIPAGE2 Cohort Study Follow up at Five and a Half Years
Epipage 2 (epidemiologic study on small-for-gestational-age children) is a nationwide study implemented to improve our knowledge of the outcome of preterm children in France.
- Trial name
- EPIPAGE2 (NCT03078439)
- Testing
- Medical and neuropsychological assessments
- Where
- 98 sites in France, French Guiana and 2 more
- Volunteers
- 3,404 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Down Syndrome
Qualitative Exploratory Study Among Reunionese Women and Their Partners Who Have a Child With Trisomy 21
According to data from French congenital malformation registries, the prevalence of Down Syndrome (DS) in 2017 (live births and medical termination of pregnancy (MToP)) in Reunion Island was the lowest in France (23.04 per 10,000…
- Trial name
- QUALI-21 (NCT04811534)
- Testing
- Interview
- Where
- 2 sites in Reunion
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Coronary Surgery
Uncalibrated Pulse Contour to Assess Fluid Responsiveness in Off Pump Cardiac Surgery
The goal of this observational study is to Compare the performance of uncalibrated pulse wave contour analysis compared with transesophageal echocardiography (TEE) to assess response to a vascular filling test during…
- Trial name
- UPC-OPCS (NCT06822361)
- Where
- Reunion
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Stress
Impact of a Self-hyPnOsis Practice on Chronic StresS Among Caregivers of Elderly People With Loss of Autonomy at Home
In France, stress particularly affects family caregivers because of the intensive help they provide on a permanent basis to people losing their autonomy at home.
- Trial name
- POSSAID (NCT04909970)
- Testing
- Self-hypnosis, Control (Waiting list)
- Where
- Reunion
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Neurocognitive Deficit
Concordance Between Mini-Mental Stats Examination (MMSE) and an Adapted Version of the MMSE in Reunion Island Population (MMS-Run)
Illeteracy concerns more than 38% of Réunion Island's people older than 65 years old, which makes it an important risk factor for dementia and a limit to neurocognitive test's administration.
- Trial name
- MMS-R-ep (NCT05858489)
- Testing
- Mini-Mental State Examination (MMSE)
- Where
- Reunion
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Dialysis
Study of the Determinants of Emergency Dialysis in Reunion Island
Among patients followed by nephrologists, the frequency of emergency dialysis starts' and their social and clinical determinants are not well known, especially in Reunion Island.
- Trial name
- PEPER (NCT05305781)
- Where
- Reunion
- Volunteers
- 233 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Chikungunya
Post-Chikungunya Rheumatism - Rheumatology Follow-up of Patients After 15 Years
Reunion Island was struck by a severe Chikungunya outbreak in 2005-2006. Three hundred and seven Chikungunya patients were evaluated by 4 rheumatologists 2 months after the initial infection (RHUMATOCHIK study).
- Trial name
- ChikRhuma15 (NCT04838574)
- Testing
- 15 years Follow-up group
- Where
- 3 sites in Reunion
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Running, Immune Deficiency
Assessment of the Increased Risk of Infection Following an Ultratrail
The increase in the practice of running has encouraged a proliferation of studies evaluating the impact of this sport on health. A number of these studies have looked at the influence of endurance events on the immune system.
- Conditions
- Running, Immune Deficiency, Infections
- Trial name
- INFultra (NCT06089174)
- Testing
- Ultra-trail
- Where
- Reunion
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Dengue
Pilot Study to Detect DENGUE Virus in Sperm
The purpose of this study is to seek the presence of dengue virus in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa.
- Trial name
- DENGSPERM (NCT03612609)
- Testing
- blood, urine and semen sample
- Where
- Reunion
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Physical Activity, Cancer
Cardiac Coherence Combined With Personal Physical Activity in Patients With Cancer
APACCHE (Adapted Physical Activity and Cardiac Coherence in HEmatologic patients) study investigates effects of heart rate variability biofeedback training, combined with classical adapted physical activity, on health-related…
- Conditions
- Physical Activity, Cancer, Hematologic Diseases
- Trial name
- APACCHE (NCT03356171)
- Testing
- Cardiac Coherence, Adapted Physical Activity
- Where
- Reunion
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Wounds Injuries
Evaluation of Musicotherapy on Pain During Wound Closure in the Emergency Department
To evaluate the effectiveness of music listening (with a musicotherapy application Music Care) on patients pain associated with care during wound suturing in the Adults emergency unit.
- Trial name
- EMERGENCE (NCT05388591)
- Testing
- Musicotherapy
- Where
- 2 sites in Reunion
- Volunteers
- 171 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Long QT Syndrome, Brugada Syndrome
Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A
In patients expressing the SCN5A-E1784K mutation (Glu1784Lys), cardiovascular risk is difficult to define as the stratification of these patients is challenging.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Cardiac Conduction System Disease, Arrhythmias, Cardiac
- Trial name
- RISKOVER (NCT05274646)
- Where
- Reunion
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
High Cholesterol, Lipodystrophy, Familial Partial
The Benefits of the Measureof Epicardial Adipose Tissue During Coronary Calcium Assessment of the Refine Cardiovascular Risk Assessment at Reunion Island.
The goal of this retrospective study is to see whether patients with familial partial type 2 lipodystrophy, who are at high cardiovascular risk present a higher volume of visceral epicardial adipose tissue than other patients…
- Conditions
- High Cholesterol, Lipodystrophy, Familial Partial, Diabetes
- Trial name
- EPICAC-RUN (NCT07090629)
- Testing
- Epicardial adipose tissue measurement on the available tododensitometry used for coronary calcium scoring
- Where
- Reunion
- Volunteers
- 126 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion