Clinical trials: in Sweden
Cardiac Arrest (CA)
Effects of a Web-based Support Programme for Cardiac Arrest Survivors
The overall goal of this clinical trial is to learn if a web-based support programme can improve wellbeing in cardiac arrest survivors by helping them manage emotional, cognitive, and physical challenges.
- Trial name
- CARDIS (NCT07240714)
- Testing
- Digital Support Programme
- Where
- 9 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Ectopic Tooth Eruption, Palatal Expansion Technique
The Effectiveness of Early Intervention to Correct the Position of PDC:s
Approximately 2-3% of children will have problems with one or both of their permanent or 'adult' canine teeth in the upper jaw. These canine teeth sometimes fail to erupt properly, because they are displaced into the roof of the…
- Conditions
- Ectopic Tooth Eruption, Palatal Expansion Technique, Randomized Clinical Trial
- Trial name
- PDC (NCT06267989)
- Testing
- Extraction of the primary canine teeth, Expansion
- Where
- 3 sites in Germany, Sweden and 1 more
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
This study will test how well a new medicine called concizumab works in the body of people with haemophilia A or B with inhibitors. The purpose is to show that concizumab can prevent bleeds in the body and is safe to use.
- Trial name
- explorer7 (NCT04083781)
- Testing
- Concizumab
- Where
- 99 sites in United States, Algeria and 27 more
- Volunteers
- 134 people
- Sponsor
- Novo Nordisk A/S
Crohn's Disease
Feasibility of a Minimally Invasive Diagnostic Algorithm in Suspected Crohn's Disease
The goal of this clinical trial is to learn whether a camera pill examination of the whole bowel can be used to diagnose Crohn's disease instead of colonoscopy and a small bowel examination (either MRI or camera pill) in patients…
- Trial name
- ANDI-3 (NCT06882993)
- Testing
- Panenteric capsule endoscopy, Ileocolonoscopy, MRI enterography
- Where
- 5 sites in Denmark, Sweden
- Volunteers
- 165 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Mucopolysaccharidosis II
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
This is a Phase 2/3, multiregional, two-arm, double-blind, randomized, active (standard-of-care)-controlled study of the efficacy and safety of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant…
- Trial name
- COMPASS (NCT05371613)
- Testing
- tividenofusp alfa, idursulfase
- Where
- 30 sites in United States, Argentina and 12 more
- Volunteers
- 65 people
- Sponsor
- Denali Therapeutics Inc.
Non-small Cell Lung Cancer
Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)
The purpose of this study is to assess efficacy and safety of neoadjuvant durvalumab in combination with platinum-based chemotherapy (CT) given as initial therapy after cancer diagnosis followed by either surgery and adjuvant…
- Trial name
- MDT-BRIDGE (NCT05925530)
- Testing
- Durvalumab
- Where
- 49 sites in United States, Austria and 9 more
- Volunteers
- 142 people
- Sponsor
- AstraZeneca
EPP, XLP
Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
To evaluate the long-term safety and tolerability of oral dersimelagon.
- Trial name
- NCT05005975
- Testing
- MT-7117
- Where
- 45 sites in United States, Australia and 13 more
- Volunteers
- 286 people
- Sponsor
- Tanabe Pharma America, Inc.
ATTR Amyloidosis
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
The overall aim of this observational study is to generate real-world evidence on the pre- and post-diagnosis disease journeys, including baseline characteristics, treatment patterns and selected clinical, economic, and…
- Trial name
- OverTTuRe (NCT06355934)
- Testing
- no intervention
- Where
- 29 sites in United States, Canada and 9 more
- Volunteers
- 52,121 people
- Sponsor
- AstraZeneca
Acute Postoperative Pain in Urological Surgery, Pain Management in Postoperative Care (Including Opioid-Sparing Approaches)
Nudging to Promote the Use of Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief
This study aims to increase the use of transcutaneous electrical nerve stimulation (TENS) for acute postoperative pain relief. TENS, a non-pharmacological treatment using electrical impulses, can enhance pain relief, reduce…
- Trial name
- Nudging pain (NCT06696430)
- Testing
- Educational Intervention on TENS Usage, Nudging Intervention to Promote TENS Usage
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Pether Jildenstal
Cancer Survivors, Anxiety
Internet-Delivered Psychological Treatment for Cancer Survivors
Negative psychological effects of cancer are common, but cancer survivors are rarely offered structured psychological treatment.
- Conditions
- Cancer Survivors, Anxiety, Depression
- Trial name
- IN-FACT-1 (NCT06046586)
- Testing
- Support and information, Behavioral activation, Systematic exposure with mindfulness training
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorder
Identification of Cellular and Molecular Mechanisms Involved in the Pathophysiology of Alcohol Use Disorder by Examination of Cerebrospinal Fluid
BACKGROUND The brain and spinal cord are enveloped by cerebrospinal fluid (CSF), which extends down to the base of the spine, a few centimeters below the termination of the spinal cord.
- Trial name
- NCT06286449
- Testing
- Spinal tap
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Lifestyle-related Condition
Prevention of Lifestyle-related Disorders Based on Functional Examinations
The goal of this randomised controlled trial is to examine the effects of functional examinations and feedback/support on healthy 40-year-olds.
- Trial name
- PREVFUNKTION (NCT06309342)
- Testing
- PREVFUNKTION, Control
- Where
- 2 sites in Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Lena Bornhoft
Overweight, Obesity
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo).
- Trial name
- OASIS 5 (NCT07770841)
- Testing
- Semaglutide
- Where
- 62 sites in United States, Belgium and 8 more
- Volunteers
- 450 people
- Sponsor
- Novo Nordisk A/S
Alzheimer's Disease
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)
This study aims to evaluate the safety, tolerability, immunogenicity, pharmacokinetics, and pharmacodynamics following administration of RO7812653 in participants with eAD.
- Trial name
- NCT07234942
- Testing
- RO7812653
- Where
- 12 sites in Canada, Netherlands and 3 more
- Volunteers
- 6 people
- Sponsor
- Hoffmann-La Roche
Adenocarcinoma, Pancreatic Ductal
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
The purpose of this study is to evaluate the efficacy and safety of adjuvant autogene cevumeran plus atezolizumab and modified leucovorin, 5-fluorouracil (5-FU), irinotecan, and oxaliplatin (mFOLFIRINOX) versus mFOLFIRINOX alone…
- Trial name
- IMCODE003 (NCT05968326)
- Testing
- Autogene cevumeran, Atezolizumab, mFOLFIRINOX
- Where
- 87 sites in United States, Belgium and 8 more
- Volunteers
- 260 people
- Sponsor
- Genentech, Inc.
Chronic Kidney Disease
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled multicenter study to investigate outcomes with elecoglipron compared with placebo in participants with CKD with and without T2DM who are on…
- Trial name
- Elevate-CKD (NCT07753993)
- Testing
- Elecoglipron
- Where
- 715 sites in United States, Argentina and 35 more
- Volunteers
- 7,000 people
- Sponsor
- AstraZeneca
Appetite, Obesity and Obesity-related Medical Conditions
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite.
- Trial name
- NCT07213245
- Testing
- Meal high in energy density, high in ultra-processed food, Meal high in energy density, low in ultra-processed food, Meal low in energy density, high in ultra-processed food
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Peri-Implantitis
Air-polishing in the Treatment of Peri-implantitis
The aim of the present study is to evaluate the potential benefit of the adjunctive use of an air-polishing device in the non-surgical treatment of peri-implantitis as compared to mechanical infection control alone.
- Trial name
- NCT04847648
- Testing
- Air-polishing, Mechanical decontamination
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Childhood Cancer, Communication
Pictorial Support in Person-centred Care for Children (PicPecc)
Introduction: Person-centred care is based on the assumption that every person has resources that should be used in the care situation.
- Conditions
- Childhood Cancer, Communication, Symptoms and Signs
- Trial name
- PicPecc (NCT04433650)
- Testing
- Pictorial support in person-centred care for children (PicPecc)
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Göteborg University
Cardiometabolic Syndrome, Obesity and Cardiovascular Risk
Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk
The increasing prevalence of obesity, its serious health consequences, and the substantial economic burden on healthcare systems underscore a pressing need for effective, long-term prevention strategies that can be implemented in…
- Conditions
- Cardiometabolic Syndrome, Obesity and Cardiovascular Risk, Overweight , Obesity
- Trial name
- NCT07806279
- Testing
- Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management
- Where
- 3 sites in Sweden
- Volunteers
- 250 people
- Sponsor
- Uppsala University
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