Clinical trials: Bone Marrow Aspiration
Alcoholic Liver Cirrhosis
Study to Evaluate Hepatic Artery Injection of Autologous Human Bone Marrow-Derived MSCs in Patients With Alcoholic LC
This study is to evaluate the safety and efficacy of a single dose of Cellgram™ delivered via hepatic artery in patients with decompensated alcoholic liver cirrhosis.
- Trial name
- NCT03838250
- Testing
- Cellgram™ (Bone marrow-derived MSCs)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmicell Co., Ltd.
Treatment Complication
Autologous Bone Marrow Aspirate Concentrate Injection for the Treatment of Early Osteoarthritis:Baghdad 2022
We present a randomized controlled trial (RCT) to assess the efficacy of autologous bone marrow aspirate concentrate BMAC of 1.8x 10 9 median cellular content in the treatment of early symptomatic knee OA.
- Trial name
- NCT05193877
- Testing
- autologous bone marrow aspirate concentrate by centrifugation
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Global Stem Cell Center, Baghdad
Knee Osteoarthritis
Laser Cell Therapy for Knee Cartilage Repair
Laser pulsed energy will be delivered over an optical fiber to create channels into damaged cartilage of the knee or knees. The channels have a diameter of approximately 100 microns or less and an approximate depth of 1…
- Trial name
- NCT04001361
- Testing
- Laser Cell Therapy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Endocellutions
Myelodysplastic Syndromes
Collection of Samples of Bone Marrow Aspiration From Patients With Myelodysplastic Syndrome
The study Objective is to collect samples of bone marrow aspirates and peripheral blood of patients with MDS for use in non-clinical research to investigate mitochondrial function sequence and effect of mitochondrial augmentation.
- Trial name
- NCT06144515
- Testing
- Blood test
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Minovia Therapeutics Ltd.
Bone Marrow Biopsy Procedures
Powered Bone Marrow Aspiration and Core Biopsy System Compared to Manual Devices
This is a randomized study evaluating use of a powered bone marrow biopsy and aspiration system (OnControl by Vidacare) compared to traditional manual devices.
- Trial name
- NCT01312519
- Testing
- OnControl Bone Marrow Biopsy and Aspiration System, Manual bone marrow sampling device
- Where
- 2 sites in United States, Spain
- Volunteers
- 50 people
- Sponsor
- Vidacare Corporation
Cancer
The Expression of Antigens in Bone Marrow Samples From Volunteering Donors.
Antigen expression levels in bone marrow from volunteering donors will be analyzed. The results of this analysis will be used to establish a clinical test to identify cancer patients who could qualify to receive an…
- Trial name
- NCT00706199
- Testing
- Bone marrow aspiration
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Liver Cirrhosis
Using Autologous Bone Marrow Cells With Wharton Gel Exosomes to Stimulate Hepatic Cell Repair in Liver Cirrhosis
the study includes patients with liver cirrhosis irrespective of the stage excluding people with active tumor or other major health issue endangering life, the protocol includes the use of autologous bone marrow derived…
- Trial name
- bone marrow (NCT07374185)
- Testing
- Autologous Bone Marrow Aspirate Concentrate
- Where
- Iraq
- Volunteers
- 10 people
- Sponsor
- Global Stem Cell Center, Baghdad
Central Retinal Vein Occlusion
Treatment of Central Retinal Vein Occlusion Using Stem Cells Study
This study evaluates whether intravitreal autologous CD34+ stem cell therapy is safe, feasible and potentially beneficial in eyes with vision loss from central retinal vein occlusion (CRVO).
- Trial name
- TRUST (NCT03981549)
- Testing
- Autologous Bone Marrow CD34+ Stem Cells
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Emmes Company, LLC
Craniocervical Injuries
Case Series on Using Bone Marrow Concentrate for Alar Ligament Injuries
A prospective case series of 200 patients who have been treated with Bone Marrow Concentrate using anterior approach through posterior oropharynx for treating alar, accessory, and transverse injuries for patients with…
- Trial name
- NCT03557606
- Testing
- Alar treatment with BMC using anterior approach
- Where
- United States
- Sponsor
- Regenexx, LLC
Ischemic Heart Failure
CardiAMP Heart Failure II Trial for Patients With Ischemic Heart Failure With Reduced Ejection Fraction
Concentrated autologous bone marrow mononuclear cells (ABM MNC) contain potentially therapeutic cell factors and past studies support therapeutic benefit to patients with cardiac diseases of acute myocardial infarction, ischemia…
- Trial name
- NCT06258447
- Testing
- Autologous bone marrow mononuclear cells processed / delivered using the CardiAMP cell therapy system
- Where
- 5 sites in United States
- Volunteers
- 250 people
- Sponsor
- BioCardia, Inc.
Craniocervical Injuries
Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries
The purpose of this study is to evaluate the effectiveness of using anterior approach through the posterior oropharynx for treating alar and transverse ligament injuries with bone marrow concentrate for patients with…
- Trial name
- NCT03517761
- Testing
- Bone Marrow Concentrate treatment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Regenexx, LLC
Acute Myocardial Infarction
Rapid Delivery of Autologous Bone Marrow Derived Stem Cells in Acute Myocardial Infarction Patients.
The primary objective of the study is to determine the feasibility and safety of intracoronary administration of autologous bone marrow derived mononuclear cell product in patients at risk for clinically significant cardiac…
- Trial name
- AMIRST (NCT01536106)
- Testing
- Autologous Bone marrow mononuclear cells
- Where
- 3 sites in India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TotipotentRX Cell Therapy Pvt. Ltd.
Amyotrophic Lateral Sclerosis (ALS)
Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients
This study will evaluate the safety and efficacy of repeated administration of NurOwn® (MSC-NTF cells) therapy, which is based on transplantation of autologous bone marrow derived mesenchymal stromal cells (MSC), which are…
- Trial name
- NCT03280056
- Testing
- NurOwn® (MSC-NTF cells), Bone Marrow aspiration
- Where
- 6 sites in United States
- Volunteers
- 196 people
- Sponsor
- Brainstorm-Cell Therapeutics
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Critical Limb Ischemia (CLI)
Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System
This is a prospective, double-blinded, randomized, placebo-controlled, multi-center, pivotal clinical study in which subjects are evaluated for prevention of major limb amputation in the treatment of non-reconstructable…
- Trial name
- CLIRST III (NCT02538978)
- Testing
- Autologous Bone Marrow Concentrate (aBMC)
- Volunteers
- 224 people
- Sponsor
- Cesca Therapeutics, Inc.
Healthy
Comparing Powered Ported Bone Marrow Aspiration to Manual Standard Bone Marrow Aspiration Procedures
This single center study will compare the manual standard bone marrow aspiration device to the powered ported bone marrow aspiration device for use in the iliac crest in healthy adult volunteers.
- Trial name
- NCT02299102
- Testing
- Jamshidi Manual Standard Device, OnControl Powered Ported Device
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vidacare Corporation
Osteoarthritis, Knee
Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)
This is a randomized, single-blind, parallel, active-controlled study to evaluate the efficacy and safety of bone marrow mesenchymal stem cells (BM-MSCs), Chondrochymal®, in subjects aged 40 to 80 with knee OA.
- Trial name
- NCT05027581
- Testing
- Bone marrow mesenchymal stem cells, hyaluronic acid
- Where
- 2 sites in Taiwan
- Volunteers
- 72 people
- Sponsor
- Taiwan Bio Therapeutics Inc.
Bone Marrow Aspiration and Biopsy Specimen Collection
A Study Comparing Use of Manual and Power Bone Marrow Aspiration and Biopsy Devices in Children
The purpose of this study is to compare use of a powered bone marrow aspiration and biopsy device (OnControl) to use of a standard manual bone marrow aspiration and biopsy device to obtain bone marrow biopsy specimens in…
- Trial name
- NCT02159118
- Testing
- Manual bone marrow aspiration and biopsy device, Powered bone marrow aspiration and biopsy device
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vidacare Corporation
Critical Limb Ischemia, Peripheral Arterial Disease
Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)
This trial will evaluate the safety and efficacy of concentrated bone marrow aspirate (cBMA) to prevent or delay major amputation and/or death in subjects with critical limb ischemia (CLI) due to severe peripheral arterial…
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
- Trial name
- MOBILE (NCT01049919)
- Testing
- Bone marrow concentration device
- Where
- 25 sites in United States
- Volunteers
- 153 people
- Sponsor
- Zimmer Biomet
Refractory Angina
Study Protocol of Intramyocardial Injection of Autologous Bone Marrow Stem Cells for Refractory Angina
Therapeutic neovascularization is an innovative strategy for cardiac tissue recovery due to chronic, intense ischemia. Thus stem cell therapy has become a promising procedure for the large number of patients with refractory…
- Trial name
- ReACT (NCT01966042)
- Testing
- Local sedation, Bone Marrow Aspiration, Minithoracotomy
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- CellPraxis Bioengenharia Ltda.