Clinical trials: CPAP
Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome
Autoimmune Basis for Postural Tachycardia Syndrome
The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these…
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome, Tachycardia, Arrhythmias, Cardiac
- Trial name
- NCT02725060
- Testing
- phenylephrine, isoproterenol, 25 micro-Ci of radiation
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cancer
Impact of Continuous Positive Airway Pressure on Breathing Motion Amplitude
This study involves a breathing motion assessment in healthy subjects before and after continuous positive airway pressure (CPAP) administration using MRI images.
- Trial name
- NCT02852473
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anesthesia, Hypoxia
Assessment of Preoxygenation Strategies in the Prehospital Environment
Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.
- Trial name
- NCT02694705
- Testing
- Continuous Positive Airway Pressure (CPAP), Bag-Valve-Mask (BVM), Non-rebreather Mask (NRM)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Sleep Apnea, Obstructive
Obstructive Sleep Apnea and Biomarkers of Alzheimer's Disease
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To compare biomarkers of Alzheimer's disease in plasma samples from patients with Obstructive sleep apnea (OSA) and without OSA.
- Trial name
- NCT04905238
- Testing
- Continuous positive airway pressure
- Where
- 2 sites in Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alberto Alonso Fernandez
Snoring
Study of Nasal Airflow Pressure Optimization to Resolve Excessive Snoring
This is a prospective, interventional, study in which patients with a history of habitual snoring to determine whether low pressure nasal continuous airway pressure can reduce the frequency, duration or intensity of snoring in…
- Trial name
- SNORE (NCT01949584)
- Testing
- nasal continuous positive airway pressure less than or equal to 6 cm H2O
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- inSleep Technologies, LLC
Obstructive Sleep Apnea
Extracellular microRNA: Biomarkers of Endothelial Dysfunction in Obese Adolescents & Adults With Obstructive Sleep Apnea
Using a prospective observational approach and a clinical trial design comparing the effectiveness of continuous positive airway pressure to diet and exercise, investigators plan to evaluate how obstructive sleep apnea (OSA)…
- Trial name
- NCT03546751
- Testing
- Continuous Positive Airway Pressure, Diet And Exercise
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy
Effects of Non-invasive Ventilation on Function Diaphragmatic and Caval Distension
Introduction: Understanding how the applicability of non-invasive ventilation can directly affect the anatomy and diaphragmatic function, as well as the opening diameter of the inferior vena cava in healthy individuals is…
- Trial name
- NCT06384027
- Testing
- Non-invasive ventilation
- Where
- Brazil
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Heart Failure
Non-invasive Ventilation in Patients With Cardiac Heart Failure
Patients with heart failure (HF) have a reduced exercise tolerance as the main result of the disease. This exercise intolerance is due to heart conditions, but also to dysfunction of the respiratory and peripheral muscles.
- Trial name
- NCT05433610
- Testing
- Non-invasive Ventilation
- Where
- Argentina
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Headache Disorder, Sleep Disorder
Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea
There is a well-documented but poorly understood relationship between headache disorders (e.g. migraine, cluster headaches, awakening headaches, etc.) and sleep disorders.
- Conditions
- Headache Disorder, Sleep Disorder, Obstructive Sleep Apnea
- Trial name
- NCT00520156
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema
The primary objective is to evaluate the efficacy of continuous positive pressure on resolution of high-altitude pulmonary edema vs high flow oxygen.
- Trial name
- NCT04186598
- Testing
- CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CommonSpirit Health
Obstructive Sleep Apnea
The Study of Skeletal Muscle Function in Obstructive Sleep Apnea
The purposes of this study includes (1)to investigate inspiratory muscles and non-inspiratory muscle function in terms of strength, endurance, and fatigability in patients with obstructive sleep apnea (OSA), (2) investigate the…
- Trial name
- NCT00813852
- Testing
- exercise training, IMT
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Haemodynamic Rebound
Hemodynamic Repercussions of Noninvasive Ventilation
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for…
- Trial name
- NCT02139631
- Testing
- Noninvasive ventilation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Hypovolemia
Cerebral Oximetry in Lower Body Negative Pressure
The study aims to describe hemodynamic effects of lower body negative pressure (LBNP). 1. If and how changes in cerebral oxygen saturation (StO2) measured by near infrared spectroscopy (NIRS) relate to changes in blood flow in…
- Trial name
- NCT03009305
- Testing
- Lower body negative pressure, Continuous positive airway pressure, Positive expiratory pressure
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Sleep Disordered Breathing, Alzheimer's Disease
Sleep, Aging and Risk for Alzheimer's Disease
Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial…
- Trial name
- SARA (NCT01962779)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 2 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypertension Secondary
Characteristics of Obstructive Sleep Apnea Syndrome Related Hypertension and the Effect of Continuous Positive Airway Pressure Treatment on Blood Pressure
Obstructive sleep apnea syndrome (OSAS) causes nocturnal chronic intermittent hypoxia (CIH) that contributes to the development of hypertension.
- Trial name
- NCT03246022
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Huai'an No.1 People's Hospital
Non-Apnoeic Snorers
Snore Positive Airway Pressure Trial
This study will aim to assess the acceptance of the Snore PAP system as a treatment concept for snore. The study will subjectively assess participant and bed partner acceptability and usability of the Snore PAP system and…
- Trial name
- NCT03201055
- Testing
- Snore PAP System
- Where
- New Zealand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea, Insulin Resistance
Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea
The investigators hypothesize that obstructive sleep apnea (OSA) may lead to increased formation/accumulation of advanced glycation ends (AGEs), and that the increase in AGEs is contributed in part by increased insulin…
- Conditions
- Obstructive Sleep Apnea, Insulin Resistance, Endothelial Function, Oxidative Stress
- Trial name
- NCT00942643
- Testing
- CPAP machine
- Where
- Hong Kong
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Snoring
Home-Use Impact and Effectiveness of Cloud 9
This is an interventional study in which patients with a history of habitual snoring will use the low-pressure CPAP device at home for about 4 weeks.
- Trial name
- Cloud9 (NCT02688335)
- Testing
- Cloud9
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea
Obstructive Sleep Apnea in World Trade Center Responders
The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders.
- Trial name
- NCT01753999
- Testing
- Standard CPAP, CPAP - Flex
- Where
- 3 sites in United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey