Clinical trials: Metronidazole
Healthy
Pharmacokinetics of Transdermal Metronidazole
This is a crossover pharmacokinetic clinical study in healthy volunteers to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin treated with a micropatch.
- Trial name
- NCT05929794
- Testing
- Metronidazole 0.75% Topical Gel, Metronidazole 0.75% Topical Cream, Transdermal water loss measurement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Alveolar Osteitis
Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis
This study will compare the effectiveness of amoxicillin, metronidazole, and chlorhexidine in preventing alveolar osteitis (dry socket) following lower third molar extraction.
- Trial name
- NCT07833176
- Testing
- Amoxicillin, Metronidazole, Chlorhexidine
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Physical Abilities, FMT
Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans
The intestinal microbiome is a microbial system that is influenced by host genetics and environmental exposures such as nutrition, stress and medications.
- Trial name
- NCT05024188
- Testing
- Antibiotics, Autologous Fecal Microbiota Transplantation, Cellules Pills
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endometriosis, Endometriosis-related Pain
The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.
- Trial name
- NCT04554693
- Testing
- Metronidazole Oral
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Anal Incontinence
Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?
The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a…
- Trial name
- NCT01275560
- Testing
- Metronidazole, CArbosylane
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Trichomonas Vaginitis, Bacterial Vaginitis
Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole
This is a multi-centered, randomized, open-label, parallel, phase IV clinical trial comparing the effectiveness and cost-effectiveness of oral multi-dose metronidazole (MTZ) and oral single-dose secnidazole (SEC) for the…
- Trial name
- NCT06261840
- Testing
- Metronidazole 500 mg, Secnidazole 2000 MG
- Where
- 4 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Tulane University
Periodontal Diseases, Antibiotics
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Periodontitits is a bacteria induced inflammatory disease that destroys the supporting tissues of the tooth and leads to tooth loss.
- Conditions
- Periodontal Diseases, Antibiotics, Pharmacokinetics
- Trial name
- AMA (NCT04669717)
- Testing
- 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 7 days, 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 3 days, 1/d 500 mg Azithromycine Pfizer for 3 days
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection
To compare the eradication success rate between 10-days sequential therapy and 7-days tailored therapy based on H. pylori culture and antimicrobial susceptibility testing.
- Trial name
- NCT02373280
- Testing
- 10 day sequential therapy (Esomeprazole, amoxicillin, clarithromycin, metronidazole), 7 day tailored PPI triple therapy (clarithromycin-containing triple therapy), 7 day moxifloxacin based triple therapy [Esomeprazole, Moxifloxacin, Amoxicillin]
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Periodontitis, Periodontal Diseases
Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice
Periodontitis is a bacterial inflammatory disease and antibiotic use is being empirically used as part of its treatment. However, a clinical practice guideline on periodontal treatment adjuncts published in 2015 identified weak…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket
- Trial name
- PAAS (NCT06131021)
- Testing
- Amoxicillin, Metronidazole
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Dietary Modification
CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease
The principal goal for the study is to examine the role gut flora plays in modulating metabolism of dietary carnitine and choline in humans.
- Trial name
- CARNIVAL (NCT01731236)
- Testing
- Carnitine, Choline, Antibiotics
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Rosacea, Erythematotelangiectatic
Metronidazole SC Penetrance With Moisturizers
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation.
- Trial name
- NCT06434519
- Testing
- Metronidazole cream, Cetaphil moisturizer, CeraVe moisturizer
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Abnormal Vaginal Flora, Clindamycin Vs Metronidazole
Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated.
- Conditions
- Abnormal Vaginal Flora, Clindamycin Vs Metronidazole, High Risk Pregnancies for Preterm Labor
- Trial name
- NCT01722708
- Testing
- Clindamycin, Metronidazole
- Where
- 2 sites in Israel
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Helicobacter Pylori Infection
A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile
Gastric cancer remains a global health problem, and Chile has one of the highest GC mortality rates in the region. Helicobacter pylori (H.
- Trial name
- NCT05926804
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin
- Where
- 3 sites in Chile
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Miguel O'Ryan Gallardo
Alveolar Bone Loss
Autogenous Demineralized Dentin Graft Combined With Injectable PRF + Metronidazole Versus Autogenous Demineralized Dentin Graft Combined With Injectable PRF Versus Autogenous Demineralized Dentin Graft Alone for Alveolar Ridge Preservation
The aim of this trial is to compare the effect of autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole (sticky demineralized tooth releasing metronidazole) versus autogenous demineralized…
- Trial name
- NCT06374784
- Testing
- Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole, Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF, Alveolar ridge preservation using autogenous demineralized dentin graft alone
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Clostridium Difficile Infection (CDI)
Study of Metronidazole Delayed-Release Capsules in Comparison With Immediate-Release Tablets (Flagyl) for Safety and Pharmacokinetics
Clostridium difficile Infection (CDI) also referred to as Clostridium difficile associated diarrhea (CDAD) is an infectious disease that is commonly associated with taking broad-spectrum antimicrobials and certain cancer…
- Trial name
- NCT07251127
- Testing
- Delayed-release metronidazole, Immediate-release metronidazole
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gateway Pharmaceutical LLC
PHA1A
A Single-center, Open-label, Study Evaluating Safety and Pharmacokinetics of Single Doses of Zidebactam-Cefepime and Metronidazole Alone or in Combination.
This is a Phase I, Single-Center, Open-Label study evaluating the safety and pharmacokinetics of single doses of ZID-FEP and metronidazole alone or in combination utilizing a 3-period, crossover study design.
- Trial name
- NCT06806995
- Testing
- Zidebactam-Cefepime, Metronidazole, FEP-ZID
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Periodontitis
Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation.
- Trial name
- NCT05608564
- Testing
- Piperacillin and Tazobactam in gel form, Amoxicillin and Metronidazole
- Where
- Serbia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
HIV Coinfection
HIV And Parasitic Infection (HAPI) Study
The overall goal of this study is to determine if periodic de-worming of persons living with HIV in intestinal parasite-endemic regions will lead to decreased morbidity and mortality associated with HIV by reducing immune…
- Trial name
- HAPI (NCT05323396)
- Testing
- Antiparasitic medication
- Where
- Malawi
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill