Clinical trials: Misoprostol
Cervical Ripening and Induction of Labor
Cervical Ripening: A Comparison Between Intravaginal Misoprostol Tablet and Intracervical Foley's Catheter and Subsequent Induction of Labor, Safety and Efficacy in Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria.
The aim of this study is to compare the effectiveness and safety of Foley's catheter and misoprostol in cervical ripening.
- Trial name
- NCT02574338
- Testing
- Foley's Catheter, prostaglandin E1 analogue
- Where
- Nigeria
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Nwali Matthew Igwe
Postpartum Hemorrhage
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
Postpartum hemorrhage (PPH) is a major cause of maternal death in the developing world. An important strategy in the prevention of deaths is the use of uterotonic drugs for PPH prophylaxis.
- Trial name
- NCT01510574
- Testing
- Misoprostol
- Where
- 4 sites in Uganda
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Induced Abortion, Abortion Techniques
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
Surgical abortion in the late first trimester and early second trimester is usually performed with the aid of a cervical preparing agent, which helps to open up the uterine cervix for the procedure.
- Conditions
- Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
- Trial name
- MIMI11-15 (NCT01636063)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston University
Abortion, Induced
Cervical Preparation Before Dilation and Evacuation
The purpose of this research study is to compare three different ways of opening a woman's cervix before her second-trimester surgical abortion.
- Trial name
- NCT01751087
- Testing
- Mifepristone, misoprostol, Osmotic dilators
- Where
- 7 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Miscarriage
Letrozole Pretreatment With Misoprostol for Second-Trimester Medical Abortion
To compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of pregnancy in second trimester abortion.
- Trial name
- NCT02405156
- Testing
- Letrozole, Misoprostol
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postpartum Hemorrhage, Cesarean Section Complications
Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery
Postpartum hemorrhage (PPH) is an obstetric emergency, with an estimated incidence ranging from 2.8% to 7.9%. Recent studies indicate an increasing trend in the frequency of PPH.Although it is more commonly seen in developing…
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Delivery Complication
- Trial name
- NCT06970483
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Cervical Dilation Prior to Dilation and Evacuation
Same-day Cervical Preparation Before Dilation and Evacuation
The purpose of this randomized trial is to compare same-day cervical preparation using Dilapan-S™ plus buccal misoprostol to overnight cervical preparation using Dilapan-S™ before D\&E at 16.0 to 20.0 weeks.
- Trial name
- NCT03002441
- Testing
- Same-Day Dilapan-S, Overnight Dilapan-S
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Hysteroscopic Myomectomy
Use of Misoprostol in Hysteroscopic Myomectomy
Hysteroscopic myomectomy is typically suitable for myomas measuring under 4 cm in size. The utilization of misoprostol before the procedure can facilitate uterine access, decrease fluid absorption, and reduce blood loss…
- Trial name
- NCT06049745
- Testing
- Misoprostol 400 Microgram Oral Tablet
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assuta Ashdod Hospital
Maternal Mortality, Access to Health Care
Project to Use Community Health Workers to Reduce Maternal Deaths
The purpose of this trial is to establish if several interventions will help women in rural Tanzania access health care services during pregnancy and at the time of delivery.
- Trial name
- EWH (NCT03024905)
- Testing
- Village meeting and travel vouchers, Birth kit with misoprostol
- Where
- Tanzania
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- Bruyère Health Research Institute.
Termed Pregnancy With Indications for Labor Induction.
Oral Versus Vaginal Misoprostol for Induction of Labor
The purpose of this study is to compare the efficacy between a single dose of oral misoprostol 100 microgram and vaginal misoprostol 50 microgram for induction of labor.
- Trial name
- NCT00148473
- Testing
- Misoprostol
- Where
- Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Cervical Spasm
Laminaria and Misoprostol Before Operative Hysteroscopy
Laminaria and Misoprostol before Operative Hysteroscopy
- Trial name
- NCT03388827
- Testing
- Laminaria tent, Laminaria plus Misoprostol
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Failed Induction of Labor
Vaginal Estradiol Pretreatment in Labour Induction With Misoprostol
To assess the effect of vaginal estradiol pretreatment before vaginal misoprostol on labor induction.
- Trial name
- NCT02485821
- Testing
- Estradiol, Misoprostol
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Myoma
Safety of Tranexamic Acid in Reducing Blood Loss Myomectomy.
Uterine leiomyomas (fibroids) are the most common benign tumors among women . Fibroids are found in approximately 15% to 30% of women in the reproductive age group
- Trial name
- NCT04694677
- Testing
- women receiving tranexamic acid, women receiving misoprostol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Induced Abortion, First Trimester Abortion
Study of Clinic-based vs. Self-use of a Misoprostol-only Regimen for Induced Abortion
The goal of the study is to determine whether important clinical outcomes differ among women who access a misoprostol-only medication abortion regimen from a patent medicine vendor when compared with those who access it from a…
- Trial name
- NCT04242212
- Testing
- Misoprostol sourced from clinics, Misoprostol sourced from PMVs
- Where
- 3 sites in Nigeria
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ipas
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Induction of Labor
Induction of Labour at Term With Low Dose Oral Misoprostol Versus a Foley Catheter
Comparison of efficacy and safety of low-dose oral Misoprostol versus folley catheter for preinduction in women with an immature cervix at term.
- Trial name
- NCT06056141
- Testing
- Misoprostol 200mcg Tab, Foley Catheter
- Where
- 2 sites in Kazakhstan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kazakhstan's Medical University "KSPH"
Labor Fast
Isosorbide Mononitrate in Induction of Labour
Induction of labor is defined as the process of artificially initiating uterine contractions, prior to their spontaneous onset, with progressive effacement and dilatation of the cervix and ultimately, the delivery of the baby.
- Trial name
- NCT04482881
- Testing
- Isosorbide Mononitrate 40 MG, Isosorbide Mononitrate 60 MG, Misoprostol
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Nausea, Pain
Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days
Randomized trial which will aim to evaluate whether prophylactic use of ondansetron and ibuprofen will decrease side effects associated with medical abortion and increase patient satisfaction.
- Trial name
- NCT05819619
- Testing
- Prophylactic use of ibuprofen and ondansetron post misoprostol administration, Use of ibuprofen and ondansetron at symptom onset post misoprostol administration
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Pregnancy
Impact of Standardization on Outcomes Following Cervical Ripening
The primary purpose of this study is to determine if vaginal delivery rate is impacted by the use of standardized methods of cervical ripening. Additional outcomes will be evaluated including maternal and fetal outcomes of labor.
- Trial name
- NCT07576881
- Testing
- Cervical Ripening with a double balloon catheter only, Cervical ripening with a double balloon catheter plus misoprostol, Usual-care control group
- Where
- United States
- Volunteers
- 1,158 people, healthy volunteers welcome
- Sponsor
- Indiana University
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand