Clinical trials: Oxytocin
Substance Abuse, Opioid Dependence
Methadone Oxytocin Option
The purpose of the study is to examine the effects of intranasal oxytocin administration on social cognition in patients receiving methadone maintenance treatment (MMT), examine the effects of intranasal oxytocin administration…
- Conditions
- Substance Abuse, Opioid Dependence, Methadone Treatment
- Trial name
- MOO (NCT01728909)
- Testing
- Oxytocin, Saline Nasal Spray
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Basic Science
Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli
In this study, a randomized, placebo-controlled between-subject design is adopted to investigate the effect of a single-dose of intranasally administered OT on approach-avoidance related motivational tendencies during the…
- Trial name
- NCT04443647
- Testing
- Oxytocin
- Where
- Belgium
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cocaine Use Disorder
Neural Substrates of Emotion: Impact of Cocaine Dependence
Over one million individuals in the United States meet criteria for cocaine use disorders. Relapse rates are highest among cocaine-dependent (CD) populations. Social stress is a significant risk factor for relapse.
- Trial name
- NCT02682784
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pain
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain.
- Trial name
- NCT05761860
- Testing
- OxyCODONE 5 mg Oral Tablet, OxyCODONE 2.5 mg Oral Tablet, Oxytocin Nasal Spray (48 IU)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Autism Spectrum Disorders
Brain Imaging Study of Adults With Autism Spectrum Disorders
This research study investigates the effects of oxytocin and vasopressin on brain activity in adults with Autism Spectrum Disorders using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT01093768
- Testing
- Oxytocin, Vasopressin
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Social Psychology
Oxytocin and Learning for Teaching
One well-established cognitive theory propose a divide between social and non-social (i.e., cognitive) systems. However, recent work suggests that traditionally social systems can be utilized to enhance cognitive performance.
- Trial name
- NCT02393443
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Complications; Cesarean Section
Oxytocin to Decrease Blood Loss During Cesarean Section
The goal of this study is to determine the best dose of a drug called oxytocin, that is usually used to stop bleeding during a delivery, when used during a cesarean delivery.
- Trial name
- NCT00891150
- Testing
- Oxytocin
- Where
- Lebanon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Premature Rupture of Fetal Membranes
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
The purpose of the study is to compare between oxytocin to prostaglandin (PGE2), regarding time from induction of labor (IOL) to delivery among primiparas at term with prelabor rupture of membrane (PROM) and an unfavorable cervix.
- Trial name
- NCT02801227
- Testing
- Oxytocin, Prostaglandin E2
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Postpartum Hemorrhage, Cesarean Section Complications
Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery
Postpartum hemorrhage (PPH) is an obstetric emergency, with an estimated incidence ranging from 2.8% to 7.9%. Recent studies indicate an increasing trend in the frequency of PPH.Although it is more commonly seen in developing…
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Delivery Complication
- Trial name
- NCT06970483
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Carbetocin, Oxytocic Drugs Causing Adverse Effects in Therapeutic Use
Comparison Of The Effects Of Carbetocin And Oxytocin In C-Sectıon
Obstetric hemorrhage is the most common cause of maternal mortality worldwide and its incidence is estimated to be approximately 24%.
- Trial name
- NCT05742854
- Testing
- C-sections operations, Oxytocin, Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ege University
Placebo Analgesia
Oxytocin and Arginine Vasopressin in Pain Relief
Background: Oxytocin, a substance produced mostly in the brain, plays a role in influencing social interactions and reactions to stress, and may be related to pain.
- Trial name
- NCT01328561
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Post Anaesthetic Shivering
Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering
Post Anaesthetic Shivering is a common complication of Subarachnoid block. It is graded based on it's severity and has been known to cause various problems like patient's discomfort, hypoxia, change in hemodynamic variables of…
- Trial name
- NCT02441673
- Testing
- Nefopam, Tramadol, Metoclopramide
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Lagos State Health Service Commission
Arginine Vasopressin Deficiency, Central Diabetes Insipidus
Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls
The study aims to investigate whether intranasal oxytocin (OXT) improves sexual well-being in patients with Arginine Vasopressin Deficiency (AVP-D).
- Conditions
- Arginine Vasopressin Deficiency, Central Diabetes Insipidus, Oxytocin Deficiency
- Trial name
- OxyPLEASURE (NCT06808516)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pregnancy, Induction of Labor
Transcervical Foley Catheter With or Without Oxytocin for Induction of Labor
The purpose of the present study is to evaluate the possible benefit of concurrent IV Oxytocin infusion with trans cervical Foley catheter for pre-induction cervical ripening.
- Trial name
- NCT00684606
- Testing
- Oxytocin IV
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Postpartum Haemorrhage With Retained Placenta
Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor
The aim of this study is to compare the effectiveness of intraumbilical oxytocin and placental cord drainage in the management of third stage of labor.
- Trial name
- NCT03395730
- Testing
- Intraumbilical vein injection oxytocin, placental cord drainage, Expectant managment of 3rd stage of labour
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eslam Mohammed Abbas
Chronic Pain, Osteoarthritis, Knee
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
The purpose of this research is to evaluate the effects of oxytocin (naturally occurring hormone) given by an intramuscular (IM; into the muscle) injection, has on your parasympathetic nervous system.
- Trial name
- NCT04427709
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Phenylephrine, Cesarean Birth
Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect
Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to…
- Trial name
- NCT07420127
- Testing
- Phenylephrine bolus 75 micrograms, Phenylephrine bolus 50 micrograms
- Where
- Pakistan
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Induction of Labor
Stepwise Labor Induction Following Failure of Prostaglandin Vaginal Insert for Labor Induction
Induction of labor is one of the most common obstetrical medical procedures performed today. Iatrogenic stimulation of uterine contractions prior to the onset of spontaneous labor is undertaken for various maternal and fetal…
- Trial name
- NCT02684305
- Testing
- Administration of Propess, balloon, Intravenous oxytocin infusion
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center