Clinical trials: Oxytocin
Induction of Labor Affected Fetus / Newborn
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in nulliparous women.
- Trial name
- NCT06325007
- Testing
- Induction of labor
- Where
- 2 sites in Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Schizophrenia
Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia
The purpose of this study is to assess how oxytocin delivered intranasally changes regional brain blood flow measured by positron emission tomography (PET) in conjunction with oxygen-15 labeled water in persons with…
- Trial name
- NCT01123317
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy
Comparison of Intranasal Oxytocin Effects Using Co-administration With a Vasoconstrictor
This study aims to dissociate direct from indirectly mediated effects of intranasal oxytocin administration by using treatment with or without prior intranasal administration of a vasoconstrictor to reduce peripheral increases in…
- Trial name
- NCT04134663
- Testing
- vasoconstrictor and oxytocin treatment
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy Mothers Who Have Had Both Vaginal and Cesarean Deliveries
Comparison of Oxytocin Receptor Immunoreactivity in Placentas Obtained From Women Having Cesarean and Natural Birth
Our study examines the effects of oxytocin hormone receptors. mechanisms of placental tissue cells and therefore intrauterine development.
- Trial name
- NCT06275438
- Testing
- The delivery being performed via cesarean section surgery rather than natural childbirth
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Healthy
Effects of Oxytocin and Vasopressin on Moral Decision Making
To determine whether the neuropeptide oxytocin (OXT) and vassopressin (AVP) influence moral decision making
- Trial name
- NCT04890470
- Testing
- Oxytocin, Vasopressin
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Failed Induction (of Labor) by Oxytocin
Continuous Oxytocin Infusion Versus Pulsatile Intravenous Oxytocin for Augmentation of First Stage of Labor
Comparing continuous intravenous oxytocin infusion with pulsatile administration of intravenous oxytocin for augmentation of the first stage of labor.
- Trial name
- NCT02723461
- Testing
- Pulsatile Oxytocin, Continuous Oxytocin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Postpartum Hemorrhage
Safety, Tolerability and Pharmacokinetics (PK) Study of Oxytocin (GR121619) Administered Via an Inhaled Route in Healthy Female Volunteers
Intramuscular (IM) oxytocin is the gold standard prophylactic therapy for post partum haemorrhage (PPH). However, in resource-poor settings within the developing world, the stability and therefore effectiveness of prophylactic IM…
- Trial name
- NCT02542813
- Testing
- IM oxytocin 10 IU, IH oxytocin 50 mcg, IH oxytocin 200 mcg
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Post Partum Hemorrhage
Carbetocin in the Prevention of Primary Postpartum Haemorrhage
Postpartum haemorrhage (PPH) ranks as the first cause of maternal mortality in developing countries and it is the cause of 25% of maternal deaths worldwide.
- Trial name
- NCT06159959
- Testing
- Carbetocin
- Where
- Egypt
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Population, Egypt
Empathy, Autism
Empathy, Psychopathy and Autism: Behavioural Associations and the Role of an Oxytocin Receptor Polymorphism in a Non-clinical Adult Population
This is an investigation into the associations between psychopathic traits, autistic traits and empathy (cognitive and affective) in the general population as measured using three self report questionnaires and one behavioural…
- Conditions
- Empathy, Autism, Psychopathy
- Trial name
- NCT04746027
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Postpartum Hemorrhage
Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage
Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide.
- Trial name
- NCT05467462
- Testing
- I.V carbetocin administration, I.V Oxytocin administration, I.V carbetocin and tranexamic acid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Rehumanization Intervention, Control Intervention
Reducing Self-Dehumanization to Examine Oxytocin and Suicide Risk
The goal of this experiment is to further determine if self-dehumanization is a novel risk factor for suicide. This study will reduce self-dehumanization using a novel re-humanization condition and compare this group to a control…
- Trial name
- NCT06713473
- Testing
- Rehumanized Intervention, Control Intervention, Clinical Interview
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Florida State University
Oxytocin, Pain
Effect of Oxytocin Nasal Inhalation on Empathy Analgesia
This study recruited healthy volunteers and randomly divided them into four groups. They inhaled oxytocin or saline, and watched a pain test video with photos of acquaintances or strangers, respectively, to test whether their…
- Conditions
- Oxytocin, Pain, Empathy, Social Familiarity
- Trial name
- NCT05823441
- Testing
- Oxytocin nasal spray, Stranger, Acquaintance
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Cervical Ripening, Induction of Labor
Pharmacokinetics and Safety of the 100 Mcg Misoprostol Vaginal Insert (MVI 100)
This study will provide pharmacokinetic data for the MVI 100 (100 mcg) misoprostol vaginal insert when administered to nulliparous women at term gestation requiring cervical ripening and induction of labor.
- Trial name
- Miso-Obs-203 (NCT00528255)
- Testing
- Misoprostol Vaginal Insert (MVI 100)
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Schizophrenia, Autism Spectrum Disorder
Dyad Oxytocin Study (DOS)
The purpose of the investigators proposed study is twofold: 1) To investigate the role of the affiliative neuropeptide oxytocin in unhealthy interactions in families of patients with schizophrenia and families of patients with…
- Trial name
- DOS (NCT02302209)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Interoception
The Modulatory Effect of Oxytocin on Interoception
This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.
- Trial name
- NCT03074409
- Testing
- oxytocin
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Primary, Post Partum Hemorrhage
Prevention of Primary Postpartum Haemorrhage
Postpartum hemorrhage, is one of the most deadly complication of pregnancy worldwide and major cause of maternal mortality especially in third world countries .1 PPH affects about 5% of all women giving birth around the world 2…
- Trial name
- NCT04724187
- Testing
- Misoprostol, Oxytocin
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Healthy Male Volunteers
Oxytocin and Social Cognition
The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of…
- Trial name
- NCT01606462
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Trial of Labor After Cesarean, Vaginal Birth After Cesarean
Balloon Catheter Combined With Oxytocin Induction Among the Pregnant Women With Previous Cesarean Section
This study is a multi-center, prospective, observational clinical trial study. 924 full-term pregnant women will be enrolled as subjects, and the ratio of eligible subjects in the two groups is 1:1.
- Conditions
- Trial of Labor After Cesarean, Vaginal Birth After Cesarean, Bishop Score, Failed Mechanical Induction
- Trial name
- NCT05246761
- Testing
- Balloon catheter
- Where
- China
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Postpartum Hemorrhage
Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment
The purpose of this study is to compare the ability of an isolated sample of uterine muscle tissue (in a tissue bath) to contract in the presence of various drugs.
- Trial name
- NCT01689298
- Testing
- Oxytocin, Carbetocin
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital