Clinical trials: Pemetrexed
Lung Cancer
ERCC1 Targeted Trial
Lung cancer is the leading cause of cancer death in the UK, leading to 34 000 deaths each year (22% of cancer deaths). Non-small cell lung cancer (NSCLC) is the most common histology, accounting for approximately 80% of cases and…
- Trial name
- ET (NCT00801736)
- Testing
- Cisplatin, Paclitaxel
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- University College, London
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Dental Pulp Disease, Endodontically Treated Teeth
Post Operative Sensitivity of MTA Obturation
The aim of this study was to investigate the difference in postoperative pain caused by different root canal sealers in patients with irreversible pulpitis symptoms and no apical lesions.
- Conditions
- Dental Pulp Disease, Endodontically Treated Teeth, Endodontic Disease
- Trial name
- NCT06795282
- Testing
- MTA
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pulp Disease, Dental
Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars
The study will be self-funded by investigator and carried out on patients from outpatient clinic in Pediatric Dentistry and Public Health Department- Faculty of Dentistry, Cairo University- Egypt.
- Trial name
- NCT03580135
- Testing
- Propolis, Mineral Trioxide Aggregate
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Laser, Tooth
Efficacy of Er,Cr:YSGG Laser in Partial Pupotomy
The aim of this study was to compare the efficacy of partial pulpotomy treatment using MTA and Er,Cr:YSGG + MTA in permanent immature molar teeth with deep dentin caries.
- Conditions
- Laser, Tooth, Pulpotomy
- Trial name
- NCT04010929
- Testing
- Partial pulpotomy with laser+MTA, Partial pulpotomy with MTA
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Merve Erkmen Almaz
Reversible Pulpitis
Direct Pulp Capping Agent on Human Pulp Tissue
This in- vivo study was conducted to evaluate the response of human pulp tissue following direct pulp capping using four different pulp capping agents in premolars scheduled for extraction in patients undergoing orthodontic…
- Trial name
- NCT06435065
- Testing
- Biodentine, Mineral Tri-Oxide Aggregate, THERACAL LC
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DR SURINDER SACHDEVA
Non-small Cell Lung Cancer, First-line Treatment
Study of Autologous CIK Cell Immunotherapy Combination With PD-1 Inhibitor and Chemotherapy in the Advanced NSCLC
This prospective, unicentric, open-labe phase I study is to evaluate the effects of autologous cytokine-induced killer cell immunotherapy combination with PD-1 inhibitor and chemotherapy in the first-line treatment of…
- Trial name
- NCT03987867
- Testing
- CIK cell, Sintilimab Injection, Pemetrexed
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Dental Pulp Exposure
Pulp Capping With Two Different Agents
The purpose of this study is to determine if MTA or calcium hydroxide are more effective as pulp capping agents
- Trial name
- MTA (NCT00812877)
- Testing
- Mineral Trioxide Aggregate, Calcium Hydroxide
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Non-small Cell Lung Cancer
Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA
EGFR mutation positive advanced NSCLC patients with uncleared ctDNA have poor prognosis, whether they can benefit from combination therapy has not been reported.
- Trial name
- FOCUS-C (NCT05334277)
- Testing
- Furmonertinib, Furmonertinib/Pemetrexed/Carboplatin, Furmonertinib/Pemetrexed/Carboplatin/Bevacizumab
- Where
- 26 sites in China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Non-small Cell Lung Cancer, Metastatic Lung Cancer
Emulation of the KEYNOTE-189 Trial Using Electronic Health Records
Investigators are building an empirical evidence base supporting the utility of real-world data through the emulation of randomized controlled trials in the oncology setting.
- Trial name
- NCT05908799
- Testing
- Pembrolizumab + Pemetrexed-Platinum, Pemetrexed-Platinum
- Where
- United States
- Volunteers
- 1,854 people, healthy volunteers welcome
- Sponsor
- Aetion, Inc.
Deep Caries, Reversible Pulpitis
Similar Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine™
This study aimed to evaluate the clinical performance of White MTA (MTA, Angelus, Londrina, Brazil) and Biodentine™ in pulp capping of cariously exposed mature permanent teeth.
- Conditions
- Deep Caries, Reversible Pulpitis, Irreversible Pulpitis
- Trial name
- NCT03186690
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Pulp Capping, Dental Caries Extending to Pulp
Long-term Evaluation of Direct Pulp Capping
Calcium hydroxide and mineral trioxide aggregate have been used in vital pulp therapy with variable outcomes recorded by different study.
- Trial name
- NCT03403985
- Testing
- Calcium Hydroxide (Ca(OH)2), Mineral Trioxide Aggregate
- Where
- Jordan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Non-small Cell Lung Cancer(NSCLC)
the"Fuzheng" Therapy of TCM to Improve the Survival Quality of Early-stage NSCLC by Intervening the CTCs
Metastasis is the leading cause of death in patients with lung cancer, and circulating tumor cells(CTCs) play a key role in the process of distant metastasis.
- Trial name
- CTC-TCM-FZ (NCT02603003)
- Testing
- JinFuKang, Cisplatin, Pemetrexed
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Extensively Decayed Primary Molars
Efficacy of Totalfill® and ProRoot MTA® as Pulpotomy Agent in Primary Molars
An experimental prospective double-blind, randomized clinical trial (RCT) with parallel design. To evaluate the outcome of using 2 pulpotomy agents: Totalfill® as study group and mineral trioxide aggregate (MTA®) as a control.
- Trial name
- NCT05149651
- Testing
- Totalfill, MTA
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Ghent
EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC
ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
ETOP 15-19 ABC-lung is an international, multi-centre open-label, randomized phase II trial with two non-comparative parallel arms of atezolizumab plus bevacizumab with carboplatin-paclitaxel (Arm A) or atezolizumab, bevacizumab…
- Trial name
- ABC-lung (NCT04245085)
- Testing
- Atezolizumab, Bevacizumab, Carboplatin
- Where
- 18 sites in Germany, Singapore and 3 more
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- ETOP IBCSG Partners Foundation
Decayed Primary Molars
Partial Versus Complete Pulpotomy Using Three Different Materials in Primary Molars: a Clinical Study
The purposes of the study to compare partial pulpotomy versus complete pulpotomy in primary molars using three different materials (Formocresol, MTA, Theracal LC) .
- Trial name
- NCT05190783
- Testing
- Formocresol, MTA, TheraCal
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Non-small Cell Lung Cancer
Efficacy and Safety of HGXJT in Bone Metastatic NSCLC Patients
This is a double-blind, randomized controlled study evaluating the efficacy and safety of HGXJT in combination with ICI-based standard treatment in lung cancer patients with bone metastases.
- Trial name
- NCT05378334
- Testing
- ICI, Chemotherapy, Bone-protecting and Mass-dispersesing Decoction
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Lung Cancer, Nonsmall Cell
Pembrolizumab as Neoadjuvant Therapy for Resectable Stage IA3 to IIA Non-Small Cell Lung Cancer (NSCLC)
This is a prospective, randomized, single-site, open-label Phase II trial of neoadjuvant pembrolizumab (3 cycles) followed by surgery, versus concomitant neoadjuvant pembrolizumab with platinum doublet chemotherapy (3 cycles)…
- Trial name
- NCT04638582
- Testing
- Pembrolizumab, Carboplatin, Paclitaxel
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
NSCLC Associated With Leptomeningeal Metastases
Immune Checkpoint Inhibitors Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC
This is a prospective, single-arm, open clinical study, which was designed to evaluate the efficacy and safety of an immune checkpoint inhibitor combined with pemetrexed intrathecal injection in the treatment of patients with…
- Trial name
- NCT06132698
- Testing
- Tislelizumab or pembrolizumab, pemetrexed
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Mesothelioma
Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for MPM
Primary Objective To determine the maximum tolerated dose (MTD) of intrathoracic administration of pemetrexed when given in conjunction with cisplatin in patients with resectable malignant pleural mesothelioma MPM.
- Trial name
- NCT02838745
- Testing
- Pemetrexed, Cisplatin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine