Clinical trials: Vancomycin
Clostridioides Difficile Infection
Clostridioides Difficile Colonisation
This study will investigate experimental colonisation with non-toxigenic C.difficile (NTCD) in healthy volunteers. Main outcomes will be safety, tolerability, dose needed to obtain colonisation with NTCD to ultimately determine…
- Trial name
- CloDiCo (NCT05693077)
- Testing
- 10E4 NTCD spores, 10E7 NTCD spores, Vancomycin Oral Capsule
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Group B Streptococcal Infection
Intrapartum Effect of Vancomycin on Rectovaginal GBS Colonization
The aim of this project is to identify the duration of vancomycin administration at which group B streptococcus (GBS) colonization is eradicated from the vaginal and recto-vaginal mucosa.
- Trial name
- NCT02814318
- Testing
- Vaginal and rectovaginal swab cultures
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Spinal Stenosis Lumbar, Surgical Site Infection
Efficacy of ActiveMatrix on Spinal SSI Rate
This clinical trial seeks to provide high level of evidence on the efficacy of ActiveMatrix primarily on spinal surgical site infection rate.
- Conditions
- Spinal Stenosis Lumbar, Surgical Site Infection, Back Pain Lower Back Chronic
- Trial name
- NCT05297513
- Testing
- ActiveMatrix
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
C. Difficile, C. Difficile Infection
Clostridioides Difficile Controlled Human Infection Model
This study will investigate in healthy study subjects, the safety and tolerability of a controlled infection with Clostridioides difficile, a gut bacterium that can cause diarrhoea.
- Conditions
- C. Difficile, C. Difficile Infection, Controlled Human Infection
- Trial name
- CloDiCHI (NCT06702345)
- Testing
- encapsulated 10^4 CFU toxigenic. C. difficile spores, Vancomycin, Clindamycin
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Nephrotoxicity, Acute Kidney Injuries
Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control.
Background: Vancomycin, a key antibiotic for MRSA infections, frequently causes nephrotoxicity (kidney damage) via oxidative stress, especially at the higher doses and longer durations now recommended.
- Trial name
- NCT07873372
- Testing
- Rutin + Ascorbic Acid (RUTA C60®), Ascorbic Acid (C-Retard®)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Rhegmatogenous Retinal Detachment
Dropless Pars Plana Vitrectomy Study
To demonstrate that intraoperative use of subtenon triamcinolone acetonide at the time of surgery without postoperative eye drops is non-inferior to the regimen of postoperative eye drops following primary pars plana vitrectomy…
- Trial name
- DVS (NCT05331664)
- Testing
- Pars plana vitrectomy, Triamcinolone Acetonide 40mg/mL, Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Antimicrobial Resistance, Colonization
Fecal Microbiota Transplantation for CRE/VRE
Multidrug-resistant organisms (MDRO) present an increasingly serious public health threat to the global community.The prevalence of various MDRO, including carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant…
- Trial name
- NCT03479710
- Testing
- FMT infusion
- Where
- Hong Kong
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Total Knee Arthroplasty
Vancomycin in TKAs
Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement.
- Trial name
- NCT07282782
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Influenza
Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics
The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the…
- Trial name
- VAX-002 (NCT02154061)
- Testing
- IIV Flu Vaccine, Metronidazole, Neomycin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Surgical Site Infection
Application of Powdered Vancomycin in the Surgical Wound in Haiti
Vancomycin, a tricyclic glycopeptide antibiotic, was originally indicated for the treatment of penicillin-resistant S. Aureus. It has a bactericidal action, inhibiting the biosynthesis of the cell wall of Gram-positive bacteria.
- Trial name
- NCT05535725
- Testing
- application of powdered vancomycin in the surgical wound as prophylaxis against the occurrence of surgical site infection
- Where
- Haiti
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Clinique Ortos
Wound Infection
Vancomycin in Spine Surgery
The purpose of this study is to study how well using a powdered form of the antibiotic, vancomycin, inside the surgery wound prevents infection in patients undergoing instrumented spinal surgery for traumatic injury to the back.
- Trial name
- NCT01977989
- Testing
- Vancomycin Powder
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Rotavirus Infections, Intestinal Bacteria Flora Disturbance
The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses
The purpose of this study is to evaluate if the intestinal microbiota influences rotavirus vaccine immune responses in healthy adult volunteers.
- Conditions
- Rotavirus Infections, Intestinal Bacteria Flora Disturbance, Reaction - Vaccine Nos, Tetanus
- Trial name
- Rota-biome (NCT02538211)
- Testing
- Rotavirus vaccine, Tetanus vaccine and Pneumococcal vaccine
- Where
- Netherlands
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recurrent Clostridium Difficile Infection, Laboratory Confirmed Clostridium Difficile Infection
Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin
Recurrent CDI is a growing problem with few treatment options that provide lasting effect. Fecal transplantation has been shown in several case series to be successful in controlling recurrent CDI.
- Trial name
- NCT01226992
- Testing
- Vancomycin, Fecal Transplant
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Surgical Site Infection, Complication of Surgical Procedure
Topical Antibiotics in Surgical Site
Ankle fractures are one of the most common injuries in traumatology. It is the fourth most common fracture in general population after hip, wrist, and hand fractures.
- Trial name
- NCT05363462
- Testing
- Vancomycin 1000 MG
- Where
- Mexico
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium
Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin
The purpose of this study is to evaluate the ability of oral vancomycin in preventing Clostridioides difficile infection (CDI) in patients that are simultaneously receiving antibiotics.
- Trial name
- NCT07221708
- Testing
- Vancomycin (POC)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Primary Sclerosing Cholangitis, Biliary Atresia
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC), and if so, by what mechanism.
- Trial name
- NCT02137668
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sacramento Pediatric Gastroenterology
Pharmacokinetics and Pharmacodynamics
Vancomycin Dose Optimization in Obesity
The goal of this clinical trial is to learn how to optimize vancomycin dosing in obese adults based on weight and kidney function. It will also assess the safety of different vancomycin dosing strategies.
- Trial name
- NCT06601257
- Testing
- Vancomycin (IV)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Postoperative Complications
The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection
The study will be a pilot randomized control trial with a 1:1 patient randomization of vancomycin powder placement at the time of surgery (compared to no vancomycin placement) with the goal of reducing postoperative complications…
- Trial name
- NCT05625373
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island