Clinical trials: flow cytometry
T Cell Deficiency
Functional Exhaustion of T Cells in COVID19 Patients
The primary end-point of our prospective, observational study is to count T cells in patients with laboratory-confirmed COVID-19 and healthy controls.
- Trial name
- NCT04470323
- Testing
- Flow cytometry
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myelodysplastic Syndromes
Sterile Inflammation and Molecular Aberrations in MDS
The objective of this study is the description of the possible association between genetic mutation/aberration profiles, inflammatory tonus and clinical phenotype based on PROMs and HRQoL.
- Trial name
- InflamGen (NCT04313231)
- Testing
- Next Generation Sequencing, Tumorimmunological examinations - multiplex assays/quantitative polymerase chain reaction, flow cytometry
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Sperm Capacitation
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection
Sperm undergo complex selection processes and physiological changes as they move through the female reproductive tract. Ejaculated-sperm must undergo a set of molecular and biochemical changes globally named as capacitation in…
- Trial name
- FOSFOTIR (NCT04962100)
- Testing
- Analysis of capacitation-associated tyrosine phosphorylation in human sperm by flow cytometry
- Where
- Spain
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Pollen Allergy, Venom Allergy
Identification of B Regulatory Cells by Flow Cytometry
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients…
- Trial name
- NCT06876506
- Testing
- Venepuncture, Allergen Specific Immunotherapy
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Candidiasis
Immunological Interaction Between the Host and Candida Albicans Biofilm
Candida albicans is one of the most common nosocomial infection and the onset relies on the host immune status. The purpose of this study is to determine the immunological profile of patients infected with Candida albicans, that…
- Trial name
- NCT01919931
- Where
- Belgium
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tuberculosis, HIV
Collection of Tissue Specimens in Mali, West Africa, for HIV and Tuberculosis Research
This study, conducted in Bamako, Mali (West Africa), will collect blood and sputum samples to establish normal values for laboratory test results among Malians.
- Trial name
- NCT00341042
- Where
- Mali
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Platelet Aggregation
Measurement of Platelet Dense Granule Release in Healthy Volunteers
Aspirin has been shown to reduce cardiovascular events in at risk individuals. Elucidation of mechanisms of aspirin resistance and a possible loss of effect of aspirin over time with chronic aspirin treatment necessitate a more…
- Trial name
- NCT00942617
- Testing
- Aspirin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Skin Rejuvenation
Evaluation of the Efficacy and Tolerability of Autologous Adipose Tissue Derived Stem Cells on Facial Rejuvenation
This study is to evaluate the efficacy and tolerability of autologous adipose tissue derived stem cells in facial rejuvenation.
- Trial name
- NCT03928444
- Testing
- intradermal injection of adipose derived stem cells to one side of the face, intradermal injection of saline to one side of the face
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pancreatitis, Immune Suppression
Immun Status at Pancreatitis Patients
Pancreatitis is a common complication especially in patients with gallbladder stones, most patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20% of patients, the disease is severe and…
- Trial name
- NCT03937323
- Testing
- Blood lymphocyte subtypes and serum cytokines
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Systemic Lupus Erythematosus
The Diagnostic Utility of T Immunoglobulin G and T Immunoglobulin M Biomarkers in Patients With Systemic Lupus Erythematosus Disease : Associations With Disease Activity and Damage
The SLE is heterogeneous multisystem autoimmune disease with complex pathogenesis involves multiple cellular components of the innate and adaptive immune systems, presence of autoantibodies and immune complexes, engagement of the…
- Trial name
- NCT07136337
- Testing
- 4 ml. of fresh venous blood will be collected from each patient on EDTA tube and will be used for detection of the following : T cell immunoglobulin G ( TIgG) and T cell immunoglobulin M (TIgM) by
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes, Diabetes Mellitus
Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Sequencing
The purpose of this study is to discover early biomarkers in circulating endothelial cells for diabetes complications, by investigating circulating endothelial cells in blood samples from patients with newly diagnosed…
- Conditions
- Diabetes, Diabetes Mellitus, Proliferative Diabetic Retinopathy, Diabetic Maculopathy
- Trial name
- CEC4DC (NCT05169502)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Immune Thrombocytopenia
The Association Between Platelet Reactivity and Bleeding Risk in Adult ITP
It seems reasonable to assume that patients who present significant bleeding symptoms may have different quality of platelets than those without bleeding.
- Trial name
- NCT03377439
- Testing
- Platelet function tests
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shandong University
Ulcerative Colitis
T Lymphocyte Subsets in Ulcerative Colitis
1. Study the distribution of peripheral blood T lymphocyte subsets among ulcerative colitis patients. 2. Correlation of T-cell subsets to therapeutic response/ disease activity. 3.
- Trial name
- NCT06352515
- Testing
- Flow cytometry
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
FCM Analysis GR in Steroid-Treatment Patients
Monitoring the GR with a GR-MoAb and FITC-Dex probes by FCM would be useful and convenient in determination GR before the steroid treatment in clinical, especially in steroid resistant states, in order to design more efficient…
- Trial name
- NCT00600652
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
B-cell Chronic Lymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia
Fludarabine Phosphate, Rituximab, and Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Relapsed or Not Responded To Treatment
RATIONALE: Drugs used in chemotherapy, such as fludarabine phosphate, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00845104
- Testing
- fludarabine phosphate, rituximab, bevacizumab
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Infertility, Female
Infections and Unexplained Infertility
1. Background: In women, unexplained infertility has been associated with a range of cellular and molecular defects in the endometrium, adverse immune responses and immunological factors.
- Trial name
- NCT03581617
- Testing
- NK cell analysis, Herpesvirus detection, sHLA-G analysis
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Labor, Premature
Correlation Between Vitamin D and B Regulatory Cell in Pregnancy
During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.
- Trial name
- NCT04105881
- Testing
- Investigation
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Advanced Cancer, Healthy
Laboratory Testing for Tie-2 Expressing Monocytes (TEMs) in Blood
Tie-2 expressing monocytes (TEMs) are a specific type of blood cell that are present in healthy individuals and in people with cancer.
- Trial name
- NCT01543841
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Seminomas
Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours
Recent data suggest that sperm cells carry an epigenetic message during spermatogenesis and that this message is crucial for the future development of the embryo.
- Trial name
- GAMETH (NCT03262207)
- Testing
- Extraction genomic DNA, Analysis of methylation profiles of numerous GSI and TE, Analysis of methylation for the whole genome (sub-population of 15 samples from group 1)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Psoriasis, Obesity
Pilot Study Characterizing Adipose Tissue Leukocytes by Flow Cytometry/Microscopy in Lean, Obese and Psoriatic Subjects
Obesity is an insulin resistance-associated metabolic disorder which is a hallmark of and risk factor for type 2 diabetes and the metabolic syndrome, often linked to cardiovascular disease, certain cancers and inflammatory…
- Trial name
- NCT01856647
- Testing
- Adipose tissue biopsy (fat biopsy)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Rockefeller University