Clinical trials: gene expression analysis
Healthy, Gestational Diabetes Mellitus
Elucidation of Breast Milk Composition and Structure Over the First Year of Lactation: UC Davis Lactation Study
This observational study is designed to determine how sugars, lipids and proteins in breast milk vary among mothers; is affected by maternal diet, health and microbiota and vary over the course of lactation.
- Conditions
- Healthy, Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- NCT01817127
- Where
- United States
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Menopause
Multicentre Clinical Trial. Project EXIMe
Objective: to evaluate the effectiveness of an individualized intervention in sexual health conducted in the midwife consultation to improve the quality of life in women with Genitourinary Syndrome of Menopause.
- Trial name
- EXIMe (NCT03558451)
- Testing
- Complex intervention in sexual health, Usual care
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Head and Neck Cancer
Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers
RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients with cancer and from healthy volunteers may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00899769
- Testing
- protein expression analysis, proteomic profiling, immunoenzyme technique
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type2 Diabetes, Healthy Obesity, Metabolically
Influence of Dairy Protein Breakfast on Glycemia, Weight Loss and Clock Genes in T2D
This study in T2D patients is undertaken to evaluate the effect of previously studied 3Meals Diet, high energy breakfast (Bdiet) with milk and dairy proteins (MBdiet) versus isocaloric diet with same meal distribution but with…
- Trial name
- Mdiet (NCT03772067)
- Testing
- Continuous glucose monitoring CGM, Clock Genes m RNA expression, Postprandial Glucose
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Epilepsy
Human Intracranial Electrophysiology
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp.
- Trial name
- NCT05529264
- Testing
- Memory Tasks, Attention/arousal tasks, Language tasks
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
User Experience With Virtual Assistants in Service Settings
Effects of Virtual Assistant Features on User Experience in Service Settings
This study examines how the characteristics and performance of virtual assistants influence user experience in service settings.
- Trial name
- AVir4Services (NCT07666295)
- Testing
- High Anthropomorphism, Low Anthropomorphism, Accurate Virtual Assistant Response
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Malaga
MicroRNA Profile, Liver Transplant
MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential…
- Conditions
- MicroRNA Profile, Liver Transplant, Organ Donor
- Trial name
- NCT06611046
- Testing
- organ donor
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mar Dalmau
Sleep Deprivation, Sleep
The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on Metabolism
The study proposes to investigate whether acute total deprivation affects metabolism as measured through blood and peripheral tissues.
- Trial name
- NCT01800253
- Testing
- Inhibitory task, Blood samples, Tissue samples
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Genetic Predisposition
Comparative Genetic and Immune Response Analysis of Different COVID-19 Vaccine Candidates Using Multi-OMICS Approach
Reaction of the immune system and the body to a Coronavirus-19 (COVID-19) vaccination is so different and ultimately unpredictable has not yet been clarified.
- Trial name
- COVID 19-VAC (NCT04873128)
- Testing
- Multi-OMICS
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Autoimmune Gastritis
Clinical Characteristics, Lifestyle and Multi-omics Analysis in Autoimmune Gastritis
This research will be conducted nationwide in patients with autoimmune gastritis, focusing on their clinical characteristics, possible risk factors, and multi-omics analysis.
- Trial name
- NCT05820607
- Testing
- Microbiome, metabolome, transcriptome, genome
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Smoking, Diabetes
Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics
Periodontal wound healing is a complex multifactorial process that involves interactions among various cells, growth factors, hormones and extracellular matrices.
- Trial name
- NCT01663298
- Testing
- Dental implant surgery
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Asthma Patients
ICS+LABA Vs. ICS+LABA+Omalizumab: Impact on Asthma Control and Gene Expression
Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction, leading to wheezing, breathlessness, chest tightness, and coughing.
- Trial name
- NCT06869382
- Testing
- Foster BDP/Formoterol, Omalizimab
- Where
- Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Scarring Alopecia
Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis
The goal of this clinical trial is to evaluate the effectiveness of a non-ablative 1470 nm laser in treating scarring alopecia in adults.
- Trial name
- NCT06946550
- Testing
- 1470nm non-ablative fractional laser
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Male Infertility
Study of Sperm Molecular Factors Implicated in Male Fertility
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynaecological pathology.
- Trial name
- NCT00481403
- Testing
- Microarray analysis, Microarray
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Stage III Colorectal Cancer
Genetic and Epigenetic Determinants of Response to Fluorouracil-based Adjuvant Chemotherapy in Patients With Stage III Colorectal Cancer
The goal of this laboratory research is to look for genetic and epigenetic markers that can predict which patients with stage III colorectal cancer will benefit from fluorouracil-based adjuvant chemotherapy.
- Trial name
- NCT03127111
- Testing
- Gene mutations analysis, Gene methylation analysis, Gene expression analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Hidradenitis Suppurativa (HS), Skin Inflammation
Molecular Evaluation of TAAR1 and JAK/STAT Pathway in Hidradenitis Suppurativa
This observational translational study aims to investigate gene and protein expression in lesional and perilesional skin of patients with Hidradenitis Suppurativa (HS) compared to controls.
- Trial name
- NCT07278011
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Trakya University
Alzheimer Disease, Frontotemporal Dementia
Proteinopathies Expression in Skin of Neurodegenerative Disorders
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 [TDP43]) in skin biopsies of…
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism
- Trial name
- NCT06528964
- Testing
- Immunohistochemistry and immunofluorescence
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Familial Mediterranean Fever, Intestinal Disease
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF
This study aims to investigate the intestinal mucosal expression of key inflammatory markers, namely Interleukin-1 (IL-1), Interleukin-18 (IL-18), and Caspase-1, in patients with Familial Mediterranean Fever (FMF).
- Conditions
- Familial Mediterranean Fever, Intestinal Disease, Genetic Disease, Fever
- Trial name
- FMF (NCT06981520)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hitit University
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari