Clinical trials: medical devices
Aesthetic, Menopause
Post-Menopause Skin Rejuvenation Study
The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity.
- Conditions
- Aesthetic, Menopause, Post-menopause, Injectables
- Trial name
- NCT07205744
- Testing
- Restylane SkinBoosters Vital, Sculptra Aesthetic
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Chronic Pain, Musculoskeletal Pain
PEACE: Comparing Chronic Pain Treatment Options
The purpose of this study is to compare two types of acupuncture with usual care on treating chronic pain. This study has three groups. Two groups will received acupuncture.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Pain Management
- Trial name
- PEACE (NCT02979574)
- Testing
- Electro-Acupuncture (EA), Battle Field Acupuncture (BFA), Wait List Control (WLC)
- Where
- 7 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Myeloid Chimerism
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
Background: Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some…
- Trial name
- NCT04008368
- Testing
- CliniMACS CD34 Reagent
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Whole-body Vibration, Healthy Volunteers (HV)
WBV Reflex Latency and Mechanical Load
This study aims to investigate how the magnitude of mechanical loading affects reflex latency patterns induced by whole-body vibration (WBV).
- Conditions
- Whole-body Vibration, Healthy Volunteers (HV), Muscle Contraction, Postural Balance
- Trial name
- WBV-BMR (NCT07170709)
- Testing
- Whole-Body Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Selim Sezikli
Healthly Volunteers, Women
Psychosocial and Cardiopulmonary Outcomes Following Diaphragm-Focused IMT Training in Healthy Women
The aim of this clinical study is to determine whether diaphragm-focused IMT training has an effect on respiratory, psychosocial, and cardiovascular parameters in healthy women.
- Trial name
- NCT07553039
- Testing
- Inspiratory Muscle Training(PowerBreathe), Inspiratory Muscle Training (%0 MIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Pregnancy
Predicate and Lay User-HCP Comparison Study of a Multi-Level Urine hCG Pregnancy Test
Study volunteers will be required to conduct a home pregnancy test (HPT) at the trial center and provide a sample of urine from the same void for further testing.
- Trial name
- NCT06516211
- Testing
- Clara Pregnancy Test, Professional Marketed Pregnancy Test
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Exercise-Induced Muscle Fatigue, Fatigue Recovery
Acute Effects of High-Intensity Laser Therapy on Pain, Muscle Stiffness, and Grip Strength in Healthy Adults
The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults.
- Trial name
- HILT (NCT07895862)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Cerebral Palsy Children, Healthy Adults
Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy
The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to…
- Trial name
- CP (NCT06811545)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hypertension
The Effect of Pharmacist-Initiated Home Blood Pressure Monitoring on Blood Pressure Control in Women
To evaluate the impact of home blood pressure monitoring when used in addition to pharmacist care, compared to usual care, in women with elevated blood pressure (BP). Randomized 1:1 two-arm controlled trial.
- Trial name
- NCT05991414
- Testing
- Home blood pressure monitor, Enhanced community pharmacist care, Usual pharmacist care
- Where
- 26 sites in Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dental Implant Failed
Clinical Performance of Dual-cantilevered Single-implant Bridge
The study aims to evaluate the clinical performance (implant and prosthetic survival/ success rates) of a novel implant-supported fixed dental prosthesis design: the dual-cantilevered single implant bridge (T-Bridge) made out of…
- Trial name
- T-bridge (NCT06099717)
- Testing
- Dual-cantilevered implant bridge, 3-unit iFDP
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Ischemic Optic Neuropathy, Optic Neuritis
Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.
The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
- Conditions
- Ischemic Optic Neuropathy, Optic Neuritis, Compressive Optic Neuropathy, Traumatic Optic Neuropathy
- Trial name
- NCT05353413
- Testing
- Neuroimaging, VEP - visual evoked potential, Ophthalmology examination.
- Where
- Poland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Chronic Migraine Headache
Laser Acupuncture for Chronic Migraine: Clinical Response, Traditional Chinese Medicine Syndrome Patterns, and Brain Function
The PRISM-CM study will test whether 810-nanometer laser acupuncture reduces migraine days and related symptoms in adults with chronic migraine.
- Trial name
- PRISM-CM (NCT07891585)
- Testing
- 810 nm laser acupuncture
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Surgery, Incision, Surgical
Prevena Spine for Use in Spine Surgery
A pilot, prospective, single-center study for the investigation of the use of Prevena Vacuum-Assisted Closure devices in patients undergoing spine surgery.
- Trial name
- NCT05555355
- Testing
- Prevena Plus 125 Therapy Unit, Spine surgery
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Facial Skin Laxity
VISION Study: Visualization-Guided SMAS Treatment to Optimize Nonsurgical Lifting
The VISION study is a prospective, randomized, single-center, split-face Phase IV clinical trial evaluating whether customized multi-depth microfocused ultrasound with visualization (Ultherapy PRIME) targeting the…
- Trial name
- NCT07890987
- Testing
- Microfocused Ultrasound with Visualization (MFU-V), multi Microfocused Ultrasound with Visualization (MFU-V)
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ocean Clinic
Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3
Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb
Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical…
- Conditions
- Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy 4
- Trial name
- NCT06300996
- Testing
- Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Marco Capogrosso
Contraception
Prospective Multi-Center Trial for FemBloc Permanent Birth Control
Prospective, multi-center, international, unblinded, single-arm trial of subjects undergoing FemBloc followed by ultrasound confirmation test.
- Trial name
- FINALE (NCT05977751)
- Testing
- FemBloc
- Where
- 12 sites in United States
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Femasys Inc.
Virtual Reality Simulation
Virtual Reality-Based Simulation Training for Retrograde Anterior Column Acetabular Screw Placement in Orthopedic Residents
The goal of this study is to find out if virtual reality (VR) training helps orthopedic residents improve their skills in placing screws in the pelvic bone.
- Trial name
- NCT07515092
- Testing
- Virtual reality based simulation training, Standard Training
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Transcranial Electric Stimulation
Mechanistic Validation of Human Multipolar TES-TI: Amplitude Modulation, Frequency, and Benchmarking
This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults.
- Trial name
- MINT (NCT07752745)
- Testing
- TES-TI with hdEEG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison