Clinical trials: lifestyle and therapy programmes
HIV Infections, STI
Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infections (STI) Testing and PrEP Initiation Among Rural Men Who Have Sex With Men
The goal of this clinical trial is to test the efficacy of a mobile app, Combine, to increase the uptake of HIV and STI testing and pre-exposure prophylaxis (PrEP) over 24 months and to assess the effects of different…
- Conditions
- HIV Infections, STI, HIV Pre-exposure Prophylaxis
- Trial name
- CombineApp (NCT06205368)
- Testing
- Combine mobile app, Motivational interview, HIV/STI testing
- Where
- United States
- Volunteers
- 473 people, healthy volunteers welcome
- Sponsor
- Emory University
Healthspan Improvement, Aging
Combination Gerotherapeutic Interventions for Healthspan Improvement
This study is a 90-day interventional, randomized, controlled pilot trial exploring multi-modal gerotherapies and their impact on longevity-related outcomes.
- Conditions
- Healthspan Improvement, Aging, Longevity
- Trial name
- NCT07475546
- Testing
- Rapamycin, Naltrexone, Metformin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Sedentary Behavior
Recreational Badminton, Sleep and Melatonin
Poor sleep quality is increasingly prevalent among physically inactive young adults and is associated with adverse physical and mental health outcomes.
- Trial name
- NCT07906184
- Testing
- Recreational Badminton, To be used for comparison purposes. There is no intervention.
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Inonu University
HIV (Human Immunodeficiency Virus), Alcohol Misuse
PNF RCT to Decrease Alcohol Use and Increase HIV Prevention
Randomized controlled trial to test the preliminary efficacy and mediating mechanism of a personalized normative feedback intervention on behavioral intentions, heavy alcohol use, and HIV/STI prevention among adolescents and…
- Conditions
- HIV (Human Immunodeficiency Virus), Alcohol Misuse, STI
- Trial name
- NCT07731932
- Testing
- PNF - HIV norms, PNF - Alcohol use norms, PNF - HIV and alcohol use norms
- Where
- Uganda
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Neck Discomfort During Smartphone Use
Content Interest, Neck Posture, and Discomfort During Smartphone Use
This study will examine whether personal interest in smartphone video content changes neck discomfort, posture, and pressure pain sensitivity in young adults.
- Trial name
- NCT07907549
- Testing
- Preferred/High-Interest Smartphone Video Viewing, Neutral/Lower-Interest Smartphone Video Viewing
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Psychological Well-being, Unforgiveness
REACH Forgiveness Group Intervention Adapted for Refugees (REACH-FOR)
The goal of this study was to find out whether REACH-FOR, a group program that helps people work toward forgiving a past offense, is useful for refugees, including people who cannot read or write well.
- Conditions
- Psychological Well-being, Unforgiveness, Refugees
- Trial name
- REACH-FOR (NCT07905833)
- Testing
- REACH-FOR
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Binge Eating Disorder, Binge Eating
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents
The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based…
- Conditions
- Binge Eating Disorder, Binge Eating, Loss of Control Eating, Overweight , Obesity
- Trial name
- STOB (NCT07301541)
- Testing
- A 10-week multicomponent camp intervention for children, A BED intervention for parents
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Schizophrenia Spectrum Disorders (SSD)
Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention
The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults…
- Trial name
- NCT07743645
- Testing
- Psychosocial intervention group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Mental Health and Psychological Well-Being, Fatigue
Effects of Swimming and Tennis on Mental Health, Fatigue, and Sleep in Young Women
This study compared the effects of swimming and tennis on mental health, fatigue, and sleep quality in young women who were not regularly physically active.
- Conditions
- Mental Health and Psychological Well-Being, Fatigue, Sleep Quality
- Trial name
- NCT07906574
- Testing
- Swimming Exercise, Tennis Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fahri Safa Çınarlı
Dental Education and Teaching Learning Processes, Psychomotor Skill Learning
Motor Learning Approaches in Periodontal Treatment Education
This study aims to evaluate the effectiveness of different motor learning approaches in preclinical non-surgical periodontal treatment education among dental students.
- Conditions
- Dental Education and Teaching Learning Processes, Psychomotor Skill Learning, Periodontal Education
- Trial name
- MLSPT (NCT07672080)
- Testing
- Implicit Learning With Standard Training, Implicit Learning With Extended Training, Implicit Learning With Distributed Training
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Healthy Aging, Cognitive Function 1, Social
Robot-Assisted Tabletop Games for Community-Dwelling Older Adults
This study evaluated a 12-week robot-assisted tabletop game program for community-dwelling older adults in Taiwan. Participants attended one 100-minute group session per week for 12 weeks.
- Conditions
- Healthy Aging, Cognitive Function 1, Social, Physical Function in Older Adults
- Trial name
- NCT07907003
- Testing
- Robot-Assisted Tabletop Game Program
- Where
- Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Infertility, Poly Cystic Ovary Syndrome
The Effectiveness of CPII for Infertility Induced by PCOS in China
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and is associated with metabolic, reproductive and mental health complications.
- Trial name
- CPII-PCOS-I (NCT07906756)
- Testing
- Standard Treatment for PCOS-Induced Infertility, Counselling-Integrated Standard Care for PCOS-Induced Infertility, Personalized Care-Integrated Intervention (PII)
- Where
- 4 sites in China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Depressive Symptoms, Perinatal Loss
e-Perinatal Butterfly: An Embedded Study for Parents Experiencing Perinatal Loss
This study is part of the e-Perinatal project and is embedded within the parent e-Perinatal cluster randomized controlled trial (NCT07613008). No additional randomization is performed for this embedded study.
- Conditions
- Depressive Symptoms, Perinatal Loss, Perinatal Grief, Anxiety Symptoms
- Trial name
- e-Butterfly (NCT07898176)
- Testing
- e-Perinatal Butterfly, Standard routine maternal care
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Seville
Alcohol Use Disorder
Environment and Alcohol: A Pilot Study
Background: Alcohol use disorder (AUD) is a chronic disease that causes more than 140,000 US deaths each year. AUD treatment often includes therapy and medication.
- Trial name
- NCT06860607
- Testing
- Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV, Violence, Gender-Based
Development and Evaluation of a PrEP Decision Aid for Women Seeking Domestic Violence Services in Baltimore
This study is designed to develop and test an individual decision aid for pre-exposure prophylaxis (PrEP) tailored to Black women who have been exposed to intimate partner violence and are working with a domestic violence service…
- Conditions
- HIV, Violence, Gender-Based, Pre-Exposure Prophylaxis
- Trial name
- NCT05614492
- Testing
- Individual PrEP Decision Aid, CDC PrEP Video, Shared PrEP Decision Aid
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
PARKINSON DISEASE (Disorder), Older Adults (65-85 Years)
Perception of Action Opportunities for Obstacle Crossing in Parkinson's Disease
The study examines how individuals with Parkinson's disease, compared to healthy older adults, evaluate their ability to cross an obstacle, and the association between this evaluation, motor and cognitive status, and…
- Trial name
- NCT07907770
- Testing
- Obstacle Crossing Task
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Learning, Comprehensive Wellbeing
Future School of Comprehensive Well-Being
Good physical, mental and social health, particularly in childhood and early adolescence, are powerful predictors of positive life trajectories.
- Conditions
- Learning, Comprehensive Wellbeing, Social Wellbeing, Physical Wellbeing
- Trial name
- SchoolWell (NCT07906522)
- Testing
- Comprehensive well-being pedagogy intervention for primary and lower secondary school students
- Where
- 6 sites in Finland
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Tobacco Dependence
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year.
- Trial name
- NCT03912194
- Testing
- cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Heart Failure
Supporting Health in Veterans With Heart Failure
This study will test the effectiveness of a culturally-sensitive, telephone-based, tailored problem-solving intervention to improve physical and mental health in Veterans with heart failure (HF).
- Trial name
- CARE-HF (NCT05839067)
- Testing
- Care-HF
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Florida State University
Shared Decision Making, Health Literacy
Designing a Large Language Model Architecture for Shared Decision Making and Informed Intentions
This study investigates a novel, agentic Large Language Model (LLM) architecture designed to facilitate Shared Decision-Making (SDM) in healthcare.
- Conditions
- Shared Decision Making, Health Literacy, Patient Participation, Artificial Intelligence
- Trial name
- DEONCAI3-1 (NCT07827924)
- Testing
- Agentic LLM Chatbot, Usual Care LLM Chatbot, IQWiG Standard Brochure
- Where
- Germany
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Harding Center for Risk Literacy